L-Histidine is Found in These Foods
L-Histidine Health Effects
- Uses/Sources: The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
- Route of Exposure: Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: ORL-RAT LD<sub>50</sub> > 15000 mg/kg, IPR-RAT LD<sub>50</sub> > 8000 mg/kg, ORL-MUS LD<sub>50</sub> > 15000 mg/kg, IVN-MUS LD<sub>50</sub> > 2000 mg/kg
Mechanism of Action
|Target Name||Mechanism of Action||References|
Sodium-coupled neutral amino acid transporter 3
Histidine--tRNA ligase, cytoplasmic