Definition
Present in the seeds of Pastinaca sativa (parsnip)
Description
Isopimpinellin is found in angelica. Isopimpinellin is present in the seeds of Pastinaca sativa (parsnip) Isopimpinellin belongs to the family of Furanocoumarins. These are polycyclic aromatic compounds containing a furan ring fused to a coumarin moeity.
Top Gene Interactions
Related Pathways
Isopimpinellin Health Effects
General Information
- Health Effects: The furocoumarin 8-methoxypsoralen is carcinogenic to humans, and possibly 5-methoxypsoralen as well (L135). There is some evidence from mouse studies that other furocoumarins are carcinogenic when combined with exposure to UVA radiation (A15105). The SKLM regards the additional risk of skin cancer arising from the consumption of typical quantities of furocoumarin-containing foods, which remain significantly below the range of phototoxic doses, as insignificant. However, the consumption of phototoxic quantities cannot be ruled out for certain foods, particularly celery and parsnips, that may lead to significant increases in furocoumarin concentrations, depending on the storage, processing and production conditions. (L2157) Furocoumarin photochemotherapy is known to induce a number of side-effects including erythema, edema, hyperpigmentation, and premature aging of skin. All photobiological effects of furocoumarins result from their photochemical reactions. Because many dietary or water soluble furocoumarins are strong inhibitors of cytochrome P450s, they will also cause adverse drug reactions when taken with other drugs.
Isopimpinellin Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Prostatic Neoplasms | 24.61 |
|
| Dermatitis, Contact | 23.06 |
|
| Breast carcinoma | 19.01 |
|
| Diabetes Mellitus, Experimental | 16.38 |
|
| Obesity | 15.56 |
|
| Hyperoxia | 13.58 |
|
| Acute lymphoblastic leukemia | 13.08 |
|
| Lung Injury | 12.93 |
|
| Cardiac hypertrophy | 11.23 |
|
| Hepatomegaly | 11.12 |
|
| Splenic Diseases | 10.72 |
|
| Cholestasis | 10.56 |
|
| Colorectal cancer | 10.53 |
|
| Liver Diseases | 10.41 |
|
| Liver Neoplasms, Experimental | 10.29 |
|
| Drug-induced liver injury | 9.69 |
|
| Occupational Diseases | 9.43 |
|
| Lung Neoplasms | 9.4 |
|
| Metabolic Syndrome X | 9.2 |
|
| Osteosarcoma | 9.1 |
|