INDOLE-3-CARBINOL | SelfDecode | Genome Analysis

Indole-3-Carbinol

Obscure Chemicals

active profile

Definition

Produced from glucosinolates in Brassica sp. on crushing or cooking. Potential nutriceutical 16082211).; Indole-3-carbinol is produced by members of the family Cruciferae and particularly members of the genus Brassica, for example, cabbage, radishes, cauliflower, broccoli, Brussels sprouts, and daikon). Indole-3-carbinol is metabolized to a number of products, including the dimeric 3,3'-diindolylmethane. Both 3,3'-diindolylmethane and Indole-3-carbinol are thought to have biological effects. Indole-3-carbinol is a natural chemopreventive compound. It has multiple anticarcinogenic and antitumorigenic properties by suppressing the proliferation of certain cancer cells, including breast cancer, prostate cancer, endometrial cancer, colon cancer, and leukemic cells (PMID: 16634522

Top Gene Interactions

Related Pathways

Indole-3-Carbinol Health Effects

Indole-3-Carbinol Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Liver Cirrhosis, Experimental	165.31	References/Inference Genes References Inference genes 17347453 26739621 15996030 26435214 15772939 12632514 16688825 18251166 23341968 26806094 25380136 16116963 16097045 16126171 16953842 12586293 17565644 18458672 17072980 15095483 16609999 18555214 16579972 16552806 12389079 15650968 18221819 15362042 16085334 16539848 A2M ABCB1 ABCC2 ABCG5 ABCG8 ACTA2 AHNAK ALDH1A1 ANXA5 APP ASNS ATF3 BIRC3 C5AR1 C7 CD38 CD86 CDKN1A COL1A1 CRYAB CTGF CXCL9 CYP1A2 DDC DHRS7 EMB ENPEP EPCAM FAM89A FGF2 FOS FXYD6 GSN GSTA2 GSTA3 GSTM1 HAL HAO2 HELLS HPGDS HPSE IFNG IGFALS IGFBP1 IL10 IL1B IL33 INHBC ITGB6 KLF6 LGALS1 LGALS2 LPL LY96 MAGEE1 MMP9 MTMR7 MYC NAT8 NFE2L2 NFKBIA NIPAL2 NPAS2 NREP NRG1 OAT PAMR1 PAQR9 PFKP PLA2G12A PLAU PLIN3 PRLR PRTFDC1 PTGS2 RAB30 REEP5 RELA RELL1 RGS2 RGS5 S100A6 SRD5A1 SREBF1 STAC3 SULT2A1 TGFB1 TGFB3 TNF TNFAIP8 TPM1 TRIB3 TSPAN8 TUSC3 UBD VIM ZDHHC2 ZEB2
Prostatic Neoplasms	83.41	References/Inference Genes References Inference genes 15538743 15583422 22666205 15386377 25735316 16166285 16516039 17115417 19223546 18829485 15598783 19240160 17585057 20564326 17914592 15342424 15389811 18174250 19011039 19208208 12237244 11275366 20729295 17288544 16220300 24763052 21801027 16733517 16430655 22581815 25062956 18642328 22564066 20140206 20124447 17999153 23441843 17176215 22610119 16877366 17136230 15790600 17141945 17704407 17507624 24028178 17609663 12533788 11742035 16775185 17016690 17919073 16552752 14968442 16266977 18304461 15126378 17003774 23704919 20932324 11454671 17196171 15616829 10753955 16012746 16506214 18500220 18264096 17639508 17363613 22919386 17173048 18082198 25970160 17192053 15672864 16934689 17826523 17542986 15302576 17013881 11196146 17967524 16606632 23996089 25908785 17566973 17606477 12644816 15159307 17548701 16284379 17199135 14754878 12727815 16998812 21716162 ABCC4 ABCG5 ACSM3 AHR ALDH1A2 ATF3 BAX BCAS1 BCL2 BRCA1 BRCA2 CASP9 CCND1 CCND2 CD9 CDH13 CDKN1A CDKN1B CHEK2 CRYAB CRYL1 CTSD CYP1A1 CYP1B1 CYP7B1 DNMT3B EGFR EGR1 EPCAM EPHX1 ESR1 FBXO44 FGF2 FHIT GDF15 GGT1 GSTA1 GSTM1 GSTM3 GSTP1 GSTT1 HSP90B1 ICAM1 IL10 IL2 IL27 IL6 KLF6 LBA LPL MMP9 MTHFR MYC MYH14 NFE2L2 NQO1 PAK6 PARP1 PHGDH PLAU PSMC3IP PTGS2 RLIM SPINK1 SRD5A1 SULT2A1 SULT2B1 TGFB1 TOP2A TRAF1 TUSC3 UGT2B17 VIM WNT4 ZBTB16
Breast carcinoma	49.11	References/Inference Genes References Inference genes 25038754 20961995 22614657 16870006 18511948 17285134 19385967 25322848 17529973 16792888 17516992 17092400 17297925 22296396 25688741 12690581 26379698 12432273 15750629 16818634 17200365 20458558 19636701 21515334 20135347 10788334 22520950 16777985 22038807 20948315 22174584 17417639 16127422 22311042 16391819 18066063 16954440 12839951 19579870 21781528 17529967 18297428 25267515 23839043 20104649 23867902 7894491 21501481 17255770 23624423 22572619 21489049 18925433 11967536 19446661 19435922 18498876 16322251 11583189 19075277 26629949 21804546 24185512 24185510 17595805 18509974 18438407 19839049 16234514 12517783 22204715 20941507 23001124 20135344 15894690 23180569 18283316 25330770 17043144 18221536 16950593 15122511 23146280 20421688 20154726 19617202 10930538 20154269 18949741 21633166 18768436 23621182 12006526 16298037 22531848 25078270 17659439 24014025 ABCB1 ABCC1 ABCG2 ACTA2 AHR ANGPTL4 ARRDC3 BAX BCL2 BIRC2 BIRC5 BMP4 BRCA1 BRCA2 CAT CCND1 CCNE1 CD40 CDKN1B CENPF CHEK1 CHEK2 CLDN1 CXCL9 CYP1A1 CYP1B1 DNMT3B EFNA1 EGFR ESR1 ESRRA FGFR2 FOS GSTP1 HPSE IDO1 IFNG IL1B IL6 JUN KRT14 LBA MMP14 MMP9 MTHFR NFKBIA NQO1 NRG1 PARP1 PHGDH PIM1 PTGS2 RAF1 RELA RGS2 SFRP2 SPP1 TNF TOP2A VEGFB VIM WWOX ZEB2
Stomach Neoplasms	35.52	References/Inference Genes References Inference genes 15492468 26098866 17355264 16367923 21628965 15993841 15201584 21458988 1733439 17224647 22414649 25279216 21173787 21364753 19140230 15723263 15378696 22644300 17575124 21133646 22385256 15138205 18505952 17171786 12958204 21347786 21936542 10404093 12107286 19584167 23593346 21471434 14647439 22042947 26401016 17003101 ACAD8 AHR ANXA5 ATP6V0D2 AURKB BCL2L1 BIRC2 BIRC5 CCND1 CDK4 CDKN1A CDKN1B CHEK2 DNMT3B EGFR FGFR2 FHIT GSTP1 IL1B IL6 IRF1 IRS2 JUN KLF6 KRT20 MSLN MTHFR MUC1 MYC PLAU PPARG PPIC PTGS2 RGS2 RORA SCRN1 SLC1A2 TNF WWOX
Diabetes Mellitus, Experimental	32.56	References/Inference Genes References Inference genes 21340626 22342832 24513509 21757225 14563825 14871415 10900012 17177138 12967931 23499715 15855331 20388520 16959961 19478208 12193562 22138235 16123366 20654064 18603373 22191573 25808216 14514642 21963884 12123627 20709041 23458895 21414306 23090186 ACOT1 ATF3 BAX BCL2 BCL2L1 CASP3 CAT CHRM2 CPT1B CYP1A1 ESRRA FGF21 ICAM1 IFNG IL1B IL6 IRS2 MMP9 NQO1 PFKM PPARG PPARGC1A PTGS2 RELA S100A6 SREBF1 TGFB1 TNF
Carcinoma	31.28	References/Inference Genes References Inference genes 21489049 16316942 15637090 15302576 12606953 21332314 17173897 16061637 11196146 12376462 12417722 10485483 12203372 14522882 10426811 22180778 20663906 21458988 2228319 ABCB1 ANGPTL4 AQP1 BCL2 BCL2L1 BRCA1 CCND1 CDK4 CDS1 DBI DNMT3B EGFR EPCAM EPHX1 ESR1 FABP4 FHIT GGT1 GSTP1 GSTT1 INSIG1 LPL LY96 MYC PIK3R1 PRLR PTGS2 S100A6 SOX9 TGFB1
Hepatocellular carcinoma	27.98	References/Inference Genes References Inference genes 15341023 20084675 16374840 19919837 17510421 18425332 12024111 25822088 20698225 20818158 27022031 11509945 19363144 22649188 20514400 22561517 16127164 22634754 20512989 16799960 12029619 14563831 11872629 7892276 15509519 21472284 18230555 22022477 15565109 18559595 18553387 10629087 9029167 16698587 16086872 21147110 20214788 18639551 17615358 26189965 A2M ABCB1 BCL2L1 BIRC5 CCND1 CCNE1 CDH13 CDK4 CDKN1B CTSD CYP1A1 EGFR EPHX1 ESR1 FOS GDF15 GPC3 GSTM1 GSTP1 HHIP HTATIP2 IL6 IRS2 JUN LBA ME1 MMP9 MYC NFE2L2 NFKBIA PGD PPARG PTGS2 RRM2 SREBF1 TGFB1 TNF UBD
Mesothelioma, Malignant	27.02	References/Inference Genes References Inference genes 16850164 22784439 19190155 27032653 25162674 11453316 26139392 16697254 25756049 21543585 ADAMTS2 BCL2 CDK6 CDKN1A CXCL9 EGFR EPHX1 GSTM1 HDAC4 IFNG IL6 MSLN MUC1 PARP1 RAF1 TBL1XR1 TGFB2 VIM
Rheumatoid arthritis	26.94	References/Inference Genes References Inference genes 23897011 22450443 2001072 18794853 11978490 12833524 23143596 20080907 22446963 22104130 8391952 17379860 18617548 19192274 20453842 12566094 20008919 ABCB1 ABCC2 ABCC4 ABCG2 AHR B3GNT2 B3GNT9 BMP4 CAT CCL21 CD40 CDK6 CTGF CTSD IFNG IL10 IL1B IL6 LY96 MMP12 MTHFR NFKBIL1 PTGS2 RUNX2 TNF TRAF1
Colorectal cancer	26.33	References/Inference Genes References Inference genes 20427397 16489531 19671906 22180778 15814641 18676755 22294766 20878130 23431386 17087956 15753380 21544799 17047490 17245555 18998757 19277044 17575224 17350979 24836286 17923031 12690581 23977225 16985020 17892325 10485483 11375891 12837940 16364925 18949393 16512993 17982127 18716850 21081473 15608557 19011631 20593958 ABCB1 ABCC1 ABCC2 ABCC4 ABCG2 BCL2 BIRC5 BMP4 CABLES1 CCND1 CD9 CHEK2 CYP1A2 CYP1B1 EGFR EPHA1 FADS2 GSTM1 GSTM3 LY96 MTHFR NQO1 NXN PPARG PTGS2 RRM2 SFRP2 TGFB1 TNF
Mammary Neoplasms, Experimental	25.92	References/Inference Genes References Inference genes 16316942 15637090 21283680 8603490 12606953 22767648 12376462 12203372 14522882 14999141 2523869 15318939 25221644 ABCG2 AQP1 BRCA1 CCND1 CDK4 CDK6 CDS1 DBI EGFR EPCAM EPHX1 ESR1 FABP4 GGT1 IL10 INSIG1 LPL MMP9 PIK3R1 PRLR S100A6 SOX9 SPP1 TFF1
Colonic neoplasm	25.6	References/Inference Genes References Inference genes 7902311 10866311 12842827 21081470 15725655 19946270 11953883 16497620 16224667 12189188 19147571 21188121 18283038 15059925 25200834 18987561 14569062 19028472 17667525 20540935 16284371 12628520 10223192 12189186 20715105 17404573 20876807 A2M ACTA2 BAX BCL2 BIRC5 CCND1 CCND2 CDKN1A CRYAB DMBT1 EGFR ICAM1 IFNG IGFBP1 IL1B JUN LPL MMP12 MMP9 MTHFR MYC NFKB1 PARK2 PPARG PTGS2 RELA SLC16A1 TNF
Mesothelioma	25.24	References/Inference Genes References Inference genes 18394747 16221779 18454162 17659810 18301454 11283936 15878867 21787763 14569398 10656689 20933535 18550471 17290392 18038314 15920167 12768194 15639718 11751476 CAT CDKN1B EGFR EGR1 ESR1 FGF1 FGF2 FHIT GPC3 GSN GSTM1 IFNG MSLN MUC1 SPP1
Brain Ischemia	24.43	References/Inference Genes References Inference genes 15060315 17564305 17640816 15737438 10472989 19417757 17927297 15829914 18628779 11756504 9731615 17901229 15756928 17394460 9236716 10512912 15534175 CASP3 CASP9 CAT CCL11 CYCS EGR1 ICAM1 IL12RB1 IL1B IL6 JUN MMP9 MTHFR NFKB1 NFKBIA PARP1 PLAU PTGS2 RELA TNF TNFRSF1B
Carcinoma, Non-Small-Cell Lung	24.0	References/Inference Genes References Inference genes 18337602 17094902 21782507 21904575 21478906 17043644 21440325 22787412 22286583 24688052 23435014 22751098 21933749 22787409 20471133 20627363 21777763 22948846 26482881 11731445 16382892 24467950 21791641 21789004 11788890 15496427 21479364 9865924 21336183 22684020 16862215 22617245 ABCB1 ATF3 BIRC5 CAT CD9 CDH13 COL4A3BP EGFR FHIT GSTP1 IL10 LGALS1 MMP9 MYC NFE2L2 NQO1 PHGDH PLBD1 PSAT1 RAF1
Lung Neoplasms	23.55	References/Inference Genes References Inference genes 17389614 18337602 16108013 16061637 11376689 17000715 11074608 16007126 19336973 17311802 22481206 19946270 20512841 18298334 16289808 17418594 17114358 14587096 18625569 17909032 11641043 12466968 17077188 22369883 10959838 17416778 20934974 17902193 24880342 25640678 16391232 11884234 26372664 20716630 19180532 7614408 11872642 22072123 15981204 18508827 18927287 21552421 21541241 23523951 11307925 A2M BCL2L1 BIRC5 BRCA2 CCND1 CDH13 CDKN1A CDKN1B CHEK2 CTGF CYP1A2 CYP1B1 EGFR EPHX1 ESR1 FGFR2 FHIT FOS GSTM1 GSTP1 GSTT1 IFNG IL10 IL1B IL2 IL6 IRF1 JUN MTHFR MYC PARK2 RAF1 SPP1 TGFB1 TNF UGT2B17
Reperfusion Injury	22.64	References/Inference Genes References Inference genes 11557319 23875703 15449323 15829914 19673871 10706834 24011919 23075401 16971220 18460982 10594344 23743330 18258783 17112405 7922267 24433871 15181847 8215636 19058328 16386242 10588920 16968891 11567657 17032661 20302854 16526316 21940958 16682413 12024109 12468449 BCL2 CASP3 CAT CDKN1A EFNA5 EGR1 FGF2 FOS ICAM1 IL10 IL1B IL6 JUN MMP9 PLAU PPARG PTGS2 RELA TNF VIM
Mammary Neoplasms, Animal	20.84	References/Inference Genes References Inference genes 15637090 16316942 12606953 8603490 12376462 12203372 14522882 17173897 AQP1 BRCA1 CCND1 CDK4 CDS1 DBI EGFR EPCAM EPHX1 ESR1 FABP4 GGT1 INSIG1 LPL PIK3R1 PRLR S100A6 SOX9
Chloracne	19.56	References/Inference Genes References Inference genes 17101203 21237254 AHNAK CDK6 CDKN1B CYCS EGFR GSTM1 GSTM3 HBB TGM1
Pancreatic carcinoma	18.73	References/Inference Genes References Inference genes 23992306 16904634 24604347 16820089 22952646 15861417 15705899 26098869 12203118 25961927 16211219 21613821 25826687 10467400 20876774 11034103 11751476 17446842 10485483 10657949 19896093 11741176 AHR BCL2L1 BRCA1 BRCA2 CFLAR EPCAM MMP9 MSLN MYC NFKBIA PLAU PPARG PTGS2 SPINK1 SUGCT TGFB1 TNF VEGFB

Indole-3-Carbinol Interacts with Genes

Interaction	References
indole-3-carbinol inhibits the reaction [TNF protein affects the localization of RELA protein]	R

Interaction	References
[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1A1 mRNA	R

Interaction	References
indole-3-carbinol binds to and results in increased activity of AHR protein	R

Interaction	References
indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]	R

Interaction	References
indole-3-carbinol inhibits the reaction [IL1B protein results in increased activity of RELA protein]	R

Interaction	References
indole-3-carbinol results in increased expression of CYP1A2	R

Interaction	References
indole-3-carbinol results in increased expression of NQO1 protein	R

Interaction	References
BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]	R

Interaction	References
[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1B1 mRNA	R

Interaction	References
AHR protein affects the susceptibility to [[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased secretion of IL10 protein]	R