INDOLE-3-CARBINOL | SelfDecode | Genome Analysis

Indole-3-Carbinol

Obscure Chemicals

active profile

Definition

Produced from glucosinolates in Brassica sp. on crushing or cooking. Potential nutriceutical 16082211).; Indole-3-carbinol is produced by members of the family Cruciferae and particularly members of the genus Brassica, for example, cabbage, radishes, cauliflower, broccoli, Brussels sprouts, and daikon). Indole-3-carbinol is metabolized to a number of products, including the dimeric 3,3'-diindolylmethane. Both 3,3'-diindolylmethane and Indole-3-carbinol are thought to have biological effects. Indole-3-carbinol is a natural chemopreventive compound. It has multiple anticarcinogenic and antitumorigenic properties by suppressing the proliferation of certain cancer cells, including breast cancer, prostate cancer, endometrial cancer, colon cancer, and leukemic cells (PMID: 16634522

Top Gene Interactions

Related Pathways

Indole-3-Carbinol Health Effects

Indole-3-Carbinol Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Liver Cirrhosis, Experimental	165.31	References/Inference Genes References Inference genes 25380136 26435214 18221819 16097045 16688825 26739621 17347453 26806094 12389079 16126171 15996030 18458672 15362042 16116963 18555214 15095483 16953842 12586293 15772939 17565644 12632514 16609999 16539848 17072980 16085334 16552806 23341968 18251166 15650968 16579972 A2M ABCB1 ABCC2 ABCG5 ABCG8 ACTA2 AHNAK ALDH1A1 ANXA5 APP ASNS ATF3 BIRC3 C5AR1 C7 CD38 CD86 CDKN1A COL1A1 CRYAB CTGF CXCL9 CYP1A2 DDC DHRS7 EMB ENPEP EPCAM FAM89A FGF2 FOS FXYD6 GSN GSTA2 GSTA3 GSTM1 HAL HAO2 HELLS HPGDS HPSE IFNG IGFALS IGFBP1 IL10 IL1B IL33 INHBC ITGB6 KLF6 LGALS1 LGALS2 LPL LY96 MAGEE1 MMP9 MTMR7 MYC NAT8 NFE2L2 NFKBIA NIPAL2 NPAS2 NREP NRG1 OAT PAMR1 PAQR9 PFKP PLA2G12A PLAU PLIN3 PRLR PRTFDC1 PTGS2 RAB30 REEP5 RELA RELL1 RGS2 RGS5 S100A6 SRD5A1 SREBF1 STAC3 SULT2A1 TGFB1 TGFB3 TNF TNFAIP8 TPM1 TRIB3 TSPAN8 TUSC3 UBD VIM ZDHHC2 ZEB2
Prostatic Neoplasms	83.41	References/Inference Genes References Inference genes 11275366 21716162 10753955 25970160 19240160 20140206 16516039 25735316 17507624 25908785 17606477 17548701 18500220 11196146 16506214 25062956 17196171 16733517 17016690 15583422 17115417 19223546 17003774 18264096 17609663 15302576 20729295 17639508 18829485 22919386 20932324 16934689 16012746 11454671 17363613 17566973 20124447 22564066 17141945 18082198 11742035 16166285 17192053 20564326 16552752 17542986 15790600 17173048 14968442 15342424 24028178 18642328 17199135 23996089 17967524 16775185 22581815 17013881 16606632 15598783 18174250 23441843 23704919 15386377 16266977 17826523 16284379 22610119 15126378 17585057 16430655 12533788 17919073 15616829 14754878 16220300 12237244 16877366 15159307 17176215 24763052 12727815 17288544 17136230 17704407 19208208 21801027 17914592 16998812 19011039 15389811 12644816 15538743 18304461 17999153 15672864 22666205 ABCC4 ABCG5 ACSM3 AHR ALDH1A2 ATF3 BAX BCAS1 BCL2 BRCA1 BRCA2 CASP9 CCND1 CCND2 CD9 CDH13 CDKN1A CDKN1B CHEK2 CRYAB CRYL1 CTSD CYP1A1 CYP1B1 CYP7B1 DNMT3B EGFR EGR1 EPCAM EPHX1 ESR1 FBXO44 FGF2 FHIT GDF15 GGT1 GSTA1 GSTM1 GSTM3 GSTP1 GSTT1 HSP90B1 ICAM1 IL10 IL2 IL27 IL6 KLF6 LBA LPL MMP9 MTHFR MYC MYH14 NFE2L2 NQO1 PAK6 PARP1 PHGDH PLAU PSMC3IP PTGS2 RLIM SPINK1 SRD5A1 SULT2A1 SULT2B1 TGFB1 TOP2A TRAF1 TUSC3 UGT2B17 VIM WNT4 ZBTB16
Breast carcinoma	49.11	References/Inference Genes References Inference genes 7894491 18221536 19075277 25078270 18066063 18511948 20104649 17529967 26379698 12517783 22572619 16777985 25267515 19617202 17297925 16127422 18498876 10930538 17595805 18925433 15894690 23180569 19636701 17092400 20961995 12006526 16234514 18283316 16870006 17200365 22204715 12839951 24185510 23624423 26629949 18438407 22038807 21804546 16322251 17255770 23621182 23839043 22311042 12690581 25688741 19446661 25038754 16298037 17659439 18949741 24185512 20458558 10788334 22614657 16391819 16954440 25322848 23867902 17529973 22531848 20421688 15750629 17516992 24014025 21633166 21781528 19579870 17417639 19435922 17285134 21501481 20941507 20135344 20135347 22296396 21489049 15122511 22174584 18509974 20154726 23001124 23146280 20948315 11583189 20154269 16818634 16950593 11967536 19385967 22520950 18297428 19839049 21515334 25330770 18768436 16792888 17043144 12432273 ABCB1 ABCC1 ABCG2 ACTA2 AHR ANGPTL4 ARRDC3 BAX BCL2 BIRC2 BIRC5 BMP4 BRCA1 BRCA2 CAT CCND1 CCNE1 CD40 CDKN1B CENPF CHEK1 CHEK2 CLDN1 CXCL9 CYP1A1 CYP1B1 DNMT3B EFNA1 EGFR ESR1 ESRRA FGFR2 FOS GSTP1 HPSE IDO1 IFNG IL1B IL6 JUN KRT14 LBA MMP14 MMP9 MTHFR NFKBIA NQO1 NRG1 PARP1 PHGDH PIM1 PTGS2 RAF1 RELA RGS2 SFRP2 SPP1 TNF TOP2A VEGFB VIM WWOX ZEB2
Stomach Neoplasms	35.52	References/Inference Genes References Inference genes 12958204 10404093 15378696 21364753 23593346 18505952 22042947 21471434 21173787 17355264 15993841 21936542 21628965 19584167 19140230 21133646 17171786 17224647 15138205 22644300 15492468 22385256 21458988 15201584 1733439 16367923 25279216 26401016 12107286 14647439 22414649 17003101 21347786 15723263 17575124 26098866 ACAD8 AHR ANXA5 ATP6V0D2 AURKB BCL2L1 BIRC2 BIRC5 CCND1 CDK4 CDKN1A CDKN1B CHEK2 DNMT3B EGFR FGFR2 FHIT GSTP1 IL1B IL6 IRF1 IRS2 JUN KLF6 KRT20 MSLN MTHFR MUC1 MYC PLAU PPARG PPIC PTGS2 RGS2 RORA SCRN1 SLC1A2 TNF WWOX
Diabetes Mellitus, Experimental	32.56	References/Inference Genes References Inference genes 23090186 10900012 16959961 21414306 25808216 16123366 20388520 14871415 20654064 21757225 21963884 14563825 24513509 21340626 22138235 12967931 19478208 18603373 23458895 12193562 15855331 22342832 14514642 23499715 12123627 22191573 17177138 20709041 ACOT1 ATF3 BAX BCL2 BCL2L1 CASP3 CAT CHRM2 CPT1B CYP1A1 ESRRA FGF21 ICAM1 IFNG IL1B IL6 IRS2 MMP9 NQO1 PFKM PPARG PPARGC1A PTGS2 RELA S100A6 SREBF1 TGFB1 TNF
Carcinoma	31.28	References/Inference Genes References Inference genes 12376462 15302576 21489049 11196146 12606953 10485483 17173897 20663906 12417722 21332314 15637090 16316942 2228319 12203372 21458988 22180778 14522882 10426811 16061637 ABCB1 ANGPTL4 AQP1 BCL2 BCL2L1 BRCA1 CCND1 CDK4 CDS1 DBI DNMT3B EGFR EPCAM EPHX1 ESR1 FABP4 FHIT GGT1 GSTP1 GSTT1 INSIG1 LPL LY96 MYC PIK3R1 PRLR PTGS2 S100A6 SOX9 TGFB1
Hepatocellular carcinoma	27.98	References/Inference Genes References Inference genes 26189965 18639551 20214788 12024111 17510421 15565109 17615358 16698587 20818158 18230555 22561517 11872629 15509519 20514400 11509945 21147110 16086872 20084675 21472284 15341023 14563831 25822088 19363144 20512989 20698225 18425332 22649188 16127164 12029619 19919837 22634754 16374840 18553387 10629087 18559595 9029167 16799960 22022477 27022031 7892276 A2M ABCB1 BCL2L1 BIRC5 CCND1 CCNE1 CDH13 CDK4 CDKN1B CTSD CYP1A1 EGFR EPHX1 ESR1 FOS GDF15 GPC3 GSTM1 GSTP1 HHIP HTATIP2 IL6 IRS2 JUN LBA ME1 MMP9 MYC NFE2L2 NFKBIA PGD PPARG PTGS2 RRM2 SREBF1 TGFB1 TNF UBD
Mesothelioma, Malignant	27.02	References/Inference Genes References Inference genes 25756049 21543585 19190155 22784439 27032653 16850164 26139392 25162674 16697254 11453316 ADAMTS2 BCL2 CDK6 CDKN1A CXCL9 EGFR EPHX1 GSTM1 HDAC4 IFNG IL6 MSLN MUC1 PARP1 RAF1 TBL1XR1 TGFB2 VIM
Rheumatoid arthritis	26.94	References/Inference Genes References Inference genes 2001072 22450443 11978490 12833524 20453842 23897011 17379860 20080907 8391952 19192274 12566094 23143596 18794853 20008919 22104130 18617548 22446963 ABCB1 ABCC2 ABCC4 ABCG2 AHR B3GNT2 B3GNT9 BMP4 CAT CCL21 CD40 CDK6 CTGF CTSD IFNG IL10 IL1B IL6 LY96 MMP12 MTHFR NFKBIL1 PTGS2 RUNX2 TNF TRAF1
Colorectal cancer	26.33	References/Inference Genes References Inference genes 20427397 18998757 17087956 18676755 17350979 19277044 17892325 16512993 16489531 15814641 15608557 22294766 17245555 23431386 16364925 20593958 19671906 20878130 24836286 12690581 23977225 17047490 12837940 18949393 22180778 21544799 10485483 11375891 18716850 17923031 17575224 21081473 16985020 15753380 17982127 19011631 ABCB1 ABCC1 ABCC2 ABCC4 ABCG2 BCL2 BIRC5 BMP4 CABLES1 CCND1 CD9 CHEK2 CYP1A2 CYP1B1 EGFR EPHA1 FADS2 GSTM1 GSTM3 LY96 MTHFR NQO1 NXN PPARG PTGS2 RRM2 SFRP2 TGFB1 TNF
Mammary Neoplasms, Experimental	25.92	References/Inference Genes References Inference genes 12376462 25221644 21283680 22767648 12606953 8603490 15637090 12203372 16316942 15318939 14999141 14522882 2523869 ABCG2 AQP1 BRCA1 CCND1 CDK4 CDK6 CDS1 DBI EGFR EPCAM EPHX1 ESR1 FABP4 GGT1 IL10 INSIG1 LPL MMP9 PIK3R1 PRLR S100A6 SOX9 SPP1 TFF1
Colonic neoplasm	25.6	References/Inference Genes References Inference genes 19946270 16224667 19147571 21188121 18987561 10223192 18283038 16284371 20715105 20876807 15059925 14569062 12189188 16497620 21081470 12842827 11953883 19028472 25200834 12189186 7902311 20540935 12628520 15725655 17667525 10866311 17404573 A2M ACTA2 BAX BCL2 BIRC5 CCND1 CCND2 CDKN1A CRYAB DMBT1 EGFR ICAM1 IFNG IGFBP1 IL1B JUN LPL MMP12 MMP9 MTHFR MYC NFKB1 PARK2 PPARG PTGS2 RELA SLC16A1 TNF
Mesothelioma	25.24	References/Inference Genes References Inference genes 11283936 10656689 18550471 15920167 20933535 15878867 17659810 18454162 18394747 14569398 15639718 12768194 16221779 21787763 18301454 18038314 11751476 17290392 CAT CDKN1B EGFR EGR1 ESR1 FGF1 FGF2 FHIT GPC3 GSN GSTM1 IFNG MSLN MUC1 SPP1
Brain Ischemia	24.43	References/Inference Genes References Inference genes 9236716 17640816 11756504 9731615 10472989 15829914 15737438 15534175 17927297 17564305 17901229 19417757 15060315 10512912 15756928 17394460 18628779 CASP3 CASP9 CAT CCL11 CYCS EGR1 ICAM1 IL12RB1 IL1B IL6 JUN MMP9 MTHFR NFKB1 NFKBIA PARP1 PLAU PTGS2 RELA TNF TNFRSF1B
Carcinoma, Non-Small-Cell Lung	24.0	References/Inference Genes References Inference genes 15496427 24467950 21782507 17043644 20627363 21933749 9865924 22787412 21791641 21336183 22617245 21904575 16862215 21789004 20471133 21440325 16382892 22948846 22684020 17094902 21479364 24688052 22286583 26482881 22751098 22787409 11788890 18337602 21478906 11731445 21777763 23435014 ABCB1 ATF3 BIRC5 CAT CD9 CDH13 COL4A3BP EGFR FHIT GSTP1 IL10 LGALS1 MMP9 MYC NFE2L2 NQO1 PHGDH PLBD1 PSAT1 RAF1
Lung Neoplasms	23.55	References/Inference Genes References Inference genes 19946270 18927287 17077188 11641043 11307925 25640678 17909032 22369883 17000715 20934974 14587096 17311802 16391232 23523951 11884234 18508827 16289808 17389614 22481206 21541241 17114358 16007126 12466968 10959838 16061637 26372664 24880342 11376689 7614408 19336973 20716630 11872642 17902193 20512841 19180532 22072123 17416778 17418594 16108013 18625569 18337602 18298334 21552421 11074608 15981204 A2M BCL2L1 BIRC5 BRCA2 CCND1 CDH13 CDKN1A CDKN1B CHEK2 CTGF CYP1A2 CYP1B1 EGFR EPHX1 ESR1 FGFR2 FHIT FOS GSTM1 GSTP1 GSTT1 IFNG IL10 IL1B IL2 IL6 IRF1 JUN MTHFR MYC PARK2 RAF1 SPP1 TGFB1 TNF UGT2B17
Reperfusion Injury	22.64	References/Inference Genes References Inference genes 15449323 15829914 16386242 7922267 24011919 16526316 17112405 17032661 21940958 10594344 11557319 8215636 11567657 23743330 10706834 18258783 16682413 16968891 12024109 18460982 20302854 23075401 19673871 24433871 15181847 12468449 10588920 16971220 19058328 23875703 BCL2 CASP3 CAT CDKN1A EFNA5 EGR1 FGF2 FOS ICAM1 IL10 IL1B IL6 JUN MMP9 PLAU PPARG PTGS2 RELA TNF VIM
Mammary Neoplasms, Animal	20.84	References/Inference Genes References Inference genes 12376462 12606953 17173897 8603490 15637090 12203372 16316942 14522882 AQP1 BRCA1 CCND1 CDK4 CDS1 DBI EGFR EPCAM EPHX1 ESR1 FABP4 GGT1 INSIG1 LPL PIK3R1 PRLR S100A6 SOX9
Chloracne	19.56	References/Inference Genes References Inference genes 17101203 21237254 AHNAK CDK6 CDKN1B CYCS EGFR GSTM1 GSTM3 HBB TGM1
Pancreatic carcinoma	18.73	References/Inference Genes References Inference genes 25961927 25826687 15705899 11751476 15861417 11034103 19896093 26098869 24604347 21613821 12203118 22952646 10657949 16211219 16820089 10485483 17446842 23992306 20876774 10467400 11741176 16904634 AHR BCL2L1 BRCA1 BRCA2 CFLAR EPCAM MMP9 MSLN MYC NFKBIA PLAU PPARG PTGS2 SPINK1 SUGCT TGFB1 TNF VEGFB

Indole-3-Carbinol Interacts with Genes

Interaction	References
indole-3-carbinol inhibits the reaction [TNF protein affects the localization of RELA protein]	R

Interaction	References
[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1A1 mRNA	R

Interaction	References
indole-3-carbinol binds to and results in increased activity of AHR protein	R

Interaction	References
indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]	R

Interaction	References
indole-3-carbinol inhibits the reaction [IL1B protein results in increased activity of RELA protein]	R

Interaction	References
indole-3-carbinol results in increased expression of CYP1A2	R

Interaction	References
indole-3-carbinol results in increased expression of NQO1 protein	R

Interaction	References
BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]	R

Interaction	References
[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1B1 mRNA	R

Interaction	References
AHR protein affects the susceptibility to [[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased secretion of IL10 protein]	R