Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic. Route of Elimination: Renal excretion is a pathway of elimination. Half Life: 3-4 hours
- Uses/Sources: For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
- Health Effects: Teratogenicity: Teratogenic effects have occurred in experimental animals. Hydroxyurea use during a small number of human pregnancies has been reported. Adverse effects have not been observed in any of the exposed newborns. Reproductive Effects: Adverse reproductive effects have occurred in experimental animals. Mutagenicity: Mutagenic effects have occurred in experimental animals.Mutagenic effects have occurred in humans.
- Route of Exposure: Well absorbed from the gastrointestinal tract.
Toxicity
- Carcinogenicity: 3, not classifiable as to its carcinogenicity to humans. (L135)
- Toxicity: Oral, mouse: LD<sub>50</sub> = 7330 mg/kg; Oral, rat: LD<sub>50</sub> = 5760 mg/kg
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Ribonucleoside-diphosphate reductase large subunit Oxysterols receptor LXR-alpha |
20005847 23611293 20462199 14583450 15075397 |