Definition
A barbiturate that is effective as a hypnotic and sedative.
Description
Hexobarbital is only found in individuals that have used or taken this drug. It is a barbiturate that is effective as a hypnotic and sedative. [PubChem]Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic.
- Uses/Sources: For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.
- Health Effects: They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.
- Symptoms: Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
- Route of Exposure: Oral
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
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Gamma-aminobutyric acid receptor subunit alpha-2 Gamma-aminobutyric acid receptor subunit alpha-3 Gamma-aminobutyric acid receptor subunit alpha-4 Gamma-aminobutyric acid receptor subunit alpha-5 Gamma-aminobutyric acid receptor subunit alpha-6 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit alpha-7 Glutamate receptor 2 Glutamate receptor ionotropic, kainate 2 |
10487207 11264449 16248797 10209232 |
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Gamma-aminobutyric acid receptor subunit alpha-1 Methyl-CpG-binding domain protein 2 |
Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. |
17016423 17139284 11957744 414931 174709 3868358 3792217 |
Hexobarbital Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Prostatic Neoplasms | 7.96 |
|
| Generalized Epilepsy With Febrile Seizures Plus, Type 3 | 7.69 |
|
| Drug Metabolism, Poor, CYP2C19-Related | 7.4 | |
| Generalized Epilepsy With Febrile Seizures Plus, Type 1 | 7.0 |
|
| Febrile seizures | 6.3 |
|
| Primary ovarian insufficiency | 6.2 |
|
| Epilepsy, Absence | 5.8 |
|
| Epilepsies, Myoclonic | 5.78 |
|
| Alcohol dependence | 5.54 |
|
| Hepatic Encephalopathy | 5.37 |
|
| Amphetamine-Related Disorders | 5.21 | |
| Kidney Failure, Chronic | 4.91 |
|
| Hepatitis C | 4.86 |
|
| Osteosarcoma | 4.7 |
|
| Cocaine dependence | 4.65 |
|
| Thrombosis | 4.64 |
|
| Cardiovascular disease | 4.58 |
|
| Torsades de pointes | 4.3 |
|
| Acute kidney injury | 4.21 |
|
| Drug-induced liver injury | 3.82 |
|