Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Halothane is metabolized in the liver, primarily by CYP2E1, and to a lesser extent by CYP3A4 and CYP2A6.
- Uses/Sources: For the induction and maintenance of general anesthesia
- Health Effects: Damage or injury to the liver.
- Symptoms: Asymptomatic - mild liver damage, nausea, vomitting, abdominal pain, loss of appetite.
- Treatment: In the event of overdosage, or what may appear to be overdosage, drug administration should be stopped, and assisted or controlled ventilation with pure oxygen initiated. There is no specific antidote. Treatment should be aimed at maintaining respiratory function (by moving the patient to fresh air or inserting an emergency airway with respiratory support) and cardiovascular function. Cases of internal ingestion must be treated symptomatically. (L1712)
- Route of Exposure: inhalation
Mechanism of Action
Target Name | Mechanism of Action | References |
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Glutamate receptor ionotropic, NMDA 2A Glutamate receptor ionotropic, NMDA 3B Glutamate receptor ionotropic, NMDA 3A Calcium-activated potassium channel subunit alpha-1 GABA-A receptor (anion channel) Potassium channel subfamily K member 3 Potassium channel subfamily K member 9 Fas-binding factor 1 |
17242087 20519544 8968191 10794813 20217349 10592235 |
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Serum albumin Calcium-transporting ATPase type 2C member 1 Gamma-aminobutyric acid receptor subunit alpha-1 NADH-ubiquinone oxidoreductase chain 1 G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 2 Glutamate receptor 1 Intermediate conductance calcium-activated potassium channel protein 4 Glycine receptor subunit alpha-1 ATP synthase subunit delta, mitochondrial Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Rhodopsin Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Neuropeptide S receptor |
Halothane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Halothane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Halothane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor. |
11814301 11960499 14759223 17139284 16243998 11157886 11961592 10794813 17016423 12826849 11455015 11961111 12118010 15175324 14739810 15385643 11465552 10913255 12657848 11834892 |