Definition
A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Constit. of Gossypium hirsutum (cotton)
Description
(-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton). (-)-gossypol has been shown to exhibit anti-tumor, anti-cancer and anti-proliferative functions (A7832, A7833, A7834).
Top Gene Interactions
Related Pathways
Gossypol Health Effects
- Angiotensin converting enzyme inhibitor
- Amebicide
- Anaphrodisiac
- Antibiotic
- Anti cancer
- Anti encephalitic
- Anti estrogenic
- Anti feedant
- Anti fertility
- Anti flu
- Anti herpetic
- Anti HIV
- Anti implantation
- Anti keratitic
- Anti malarial
- Antioxidant
- Anti plasmodial
- Anti progesterone
- Anti proliferant
- Anti rabies
- Anti spermatogenic
- Anti stomatitic
- Anti testosterone
- Antitumor
- Anti viral
- Avicide
- Calcium antagonist
- Contraceptive
- Cytotoxic
- Fungicide
- Hepatotoxic
- Hypokalemic
- Immunostimulant
- Insectifuge
- Larvicide
- Libidolytic
- Paralytic
- Pesticide
- Prostaglandigenic
- Prostaglandin synthesis inhibitor
- Spermicide
- Topoisomerase-II inhibitor
- Toxic
- Tumorigenic
- Aldose reductase inhibitor
- Anti bacterial
- Anti corpus-luteum
- Anti trypanosomic
- Interferonogenic
- Mutagenic
- Nematistat
General Information
- Uses/Sources: Gossypol is a plant toxin found in the cotton plant (genus Gossypium, family Malvaceae). Among other things, it has been tested as a male oral contraceptive in China. In addition to its contraceptive properties, gossypol has also long been known to possess anti-malarial properties. (L1239)
- Health Effects: Gossypol may cause low potassium levels and thus causes temporary paralysis. (L1239)
- Symptoms: Symptoms of gossypol poisoning include fatigue, muscle weakness, and at its most extreme, paralysis. (L1239)
- Route of Exposure: Oral (ingestion) (L1817) ; dermal (L1817)
Gossypol Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Diabetes Mellitus, Experimental | 24.28 |
|
| Myocardial Reperfusion Injury | 21.76 |
|
| Reperfusion Injury | 20.25 |
|
| Diabetes Mellitus, Type 2 | 19.55 |
|
| Intracerebral hemorrhage | 18.54 |
|
| Multiple myeloma | 18.54 |
|
| Liver Cirrhosis, Experimental | 17.48 |
|
| Myocardial Ischemia | 17.29 |
|
| Nerve Degeneration | 16.57 |
|
| Prostatic Neoplasms | 16.27 |
|
| Lymphoma, T-Cell, Cutaneous | 14.23 |
|
| Adenoma | 13.59 |
|
| Pulmonary Fibrosis | 13.59 |
|
| Wounds and Injuries | 12.96 |
|
| Brain Ischemia | 12.93 |
|
| Alzheimer's Disease | 12.7 |
|
| Myocardial infarction | 12.54 |
|
| Breast carcinoma | 12.24 |
|
| Lung Neoplasms | 12.15 |
|
| Status Epilepticus | 11.79 |
|