Top Gene Interactions
- Metabolism: Hepatic. Gemfibrozil mainly undergoes oxidation of a ring methyl group to successively form a hydroxymethyl and a carboxyl metabolite. Route of Elimination: Approximately seventy percent of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate, with less than 2% excreted as unchanged gemfibrozil. Half Life: 1.5 hours
- Uses/Sources: For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
- Symptoms: Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
- Route of Exposure: Well absorbed from gastrointestinal tract (within 1-2 hours).
- Carcinogenicity: 3, not classifiable as to its carcinogenicity to humans. (L135)
- Toxicity: Oral, mouse: LD<sub>50</sub> = 3162 mg/kg.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Peroxisome proliferator-activated receptor alpha
Peroxisome proliferator-activated receptor gamma