Top Gene Interactions
- Metabolism: Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration. Route of Elimination: Flutamide and its metabolites are excreted mainly in the urine with only 4.2% of a single dose excreted in the feces over 72 hours. Half Life: The plasma half-life for the alpha-hydroxylated metabolite of flutamide (an active metabolite) is approximately 6 hours.
- Uses/Sources: For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
- Symptoms: In animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.
- Route of Exposure: Rapidly and completely absorbed.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Aryl hydrocarbon receptor
Nuclear receptor subfamily 1 group I member 2
5-hydroxytryptamine receptor 6
Thromboxane A2 receptor
Cytochrome P450 1A2
Cytochrome P450 2C19