Definition
Flavones (flavus = yellow), are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). (Wikipedia)
Description
Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action.
Top Gene Interactions
Related Pathways
Flavone Health Effects
- Allergenic
- Analgesic
- Anti aflatoxin
- Anti aggregant
- Anti bacterial
- Anti escherichic
- Anti estrogenic
- Anti histaminic
- Anti leukemic
- Anti mutagenic
- Anti proliferant
- Anti staphylococcic
- Anxiolytic
- Bacteristat
- Cyclooxygenase inhibitor
- Cytotoxic
- Estrogenic
- Fungicide
- Hepatoprotective
- Lipoxygenase inhibitor
- Mutagenic
- Pesticide
General Information
- Uses/Sources: In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Estrogen receptor Estrogen receptor beta Aryl hydrocarbon receptor Androgen receptor Steroid hormone receptor ERR1 Steroid hormone receptor ERR2 Cytochrome P450 3A4 Peroxisome proliferator-activated receptor gamma Cytochrome P450 1B1 |
12224631 21053930 20436506 23611293 19563207 14638870 |
Flavone Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Breast carcinoma | 48.7 |
|
Prostatic Neoplasms | 33.4 |
|
Brain Ischemia | 32.68 |
|
Atherosclerosis | 31.12 |
|
Reperfusion Injury | 21.79 |
|
Diabetes Mellitus, Experimental | 21.53 |
|
Lung Injury | 19.69 |
|
Hypertension | 19.36 |
|
Silicosis | 18.28 |
|
Squamous cell carcinoma | 17.51 |
|
Infertility, Female | 17.43 |
|
Hepatocellular carcinoma | 17.24 |
|
Diabetes Mellitus, Type 2 | 16.78 |
|
Neoplasm Invasiveness | 15.57 |
|
Colorectal cancer | 15.39 |
|
Autism | 15.31 |
|
Liver Diseases | 15.2 |
|
Male infertility | 15.02 |
|
Inflammation | 14.98 |
|
Carcinoma, squamous cell of head and neck | 13.53 |
|