Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Drug is extensively metabolized, primarily in the liver via CYP3A4. Two metabolites have been identified with дЉ_20% of the activity of finasteride. Route of Elimination: Following an oral dose of 14C-finasteride in man (n = 6), a mean of 39% (range, 32 to 46%) of the dose was excreted in the urine in the form of metabolites; 57% (range, 51 to 64%) was excreted in the feces. Urinary excretion of metabolites was decreased in patients with renal impairment. This decrease was associated with an increase in fecal excretion of metabolites. Half Life: 4.5 hours (range 3.3-13.4 hours)
- Uses/Sources: For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: Improve symptoms, reduce the risk of acute urinary retention, reduce the risk of the need for surgery including transurethral resection of the prostate. Also used for the stimulation of regrowth of hair in men with mild to moderate androgenetic alopecia (male pattern alopecia, hereditary alopecia, common male baldness).
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Androgen receptor Estrogen-related receptor gamma Peroxisome proliferator-activated receptor delta Nuclear receptor ROR-beta Bile acid receptor 3-oxo-5-alpha-steroid 4-dehydrogenase 1 3-oxo-5-alpha-steroid 4-dehydrogenase 2 3-oxo-5-beta-steroid 4-dehydrogenase |
1314830 16818707 16019620 19515843 7734398 12773767 8117686 19707263 19543428 23611293 20460827 12670724 |