Definition
An antilipemic agent which reduces both CHOLESTEROL and TRIGLYCERIDES in the blood.
Description
An antilipemic agent which reduces both cholesterol and triglycerides in the blood.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Route of Elimination: Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. Following oral administration in healthy volunteers, approximately 60% of a single dose of radiolabelled fenofibrate appeared in urine, primarily as fenofibric acid and its glucuronate conjugate and 25% was excreted in the feces. Half Life: 20 hours
- Uses/Sources: For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
- Health Effects: Investigated as a teratogen and reproductive hazard.
- Route of Exposure: Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD<sub>50</sub>=1600 mg/kg (Oral, in mice)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Cellular tumor antigen p53 Peroxisome proliferator-activated receptor alpha Bile acid receptor Metalloproteinase |
17353509 17606858 23611293 |