FAMOTIDINE

Definition

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by Merck under the trade names Pepcidine and Pepcid. [HMDB]

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Famotidine Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Reperfusion Injury	47.68	References/Inference Genes References Inference genes 10706834 16526316 16682413 17112405 23075401 21940958 12865660 23743330 18460982 11557319 23875703 18258783 16971220 8869312 8215636 10594344 19673871 15829914 17032661 12468449 16581065 7922267 20863214 19058328 12024109 CAT CXCL1 CXCL8 FGF2 FOS GHRL HSPA1A ICAM1 IL10 IL12A IL1B IL6 MMP9 MPO TNF
Radiation Injuries, Experimental	34.29	References/Inference Genes References Inference genes 22247605 11121210 IFNG IL18 IL1B MAPK1 MAPK3 TNF
Hepatitis, Autoimmune	28.76	References/Inference Genes References Inference genes 21227906 CXCL1 IFNG IL10 IL18 IL2 IL4 IL6
Ulcerative colitis	28.74	References/Inference Genes References Inference genes 19617644 21297633 20380826 24055189 18438406 12133438 22119283 15553846 15955209 20452301 18836448 20228799 CXCL8 GHRL ICAM1 IL10 IL12B IL1B MMP9 MPO TNF
Lung Neoplasms	28.56	References/Inference Genes References Inference genes 14587096 7614408 23548910 18298334 22369883 18625569 26372664 16289808 12111688 11884234 12083368 12376484 BRAF FOS IFNG IL10 IL1B IL2 IL6 MAPK1 MAPK3 MMP1 MPO TNF
Brain Ischemia	27.19	References/Inference Genes References Inference genes 9236716 19417757 15060315 15737438 17564305 15756928 15829914 17394460 17901229 CAT ICAM1 IL18 IL1B IL6 MAPK1 MAPK3 MMP9 MPO TNF
Entamoebiasis	26.94	References/Inference Genes References Inference genes 16374615 IFNG IL10 IL1B IL2 IL6
Prostatic Neoplasms	26.06	References/Inference Genes References Inference genes 15672864 24763052 17999153 21716162 25735316 25970160 15764345 16284379 17688413 12644816 19240160 17173048 16606632 16172807 17115417 17196171 17606477 19011039 18174250 BRAF CXCL8 CYP2C19 FGF2 HSPA1A ICAM1 IL10 IL18 IL2 IL6 MAPK3 MMP9 MPO SERPINE1 SLC22A3
Brain Injuries	25.91	References/Inference Genes References Inference genes 19631748 23159883 9630518 21269288 19800810 21549006 FGF2 FOS HSPA1A IL10 IL1B IL2 IL6 MMP9 MPO TNF
Pulmonary Fibrosis	25.09	References/Inference Genes References Inference genes 8952537 21468558 12574379 11394717 26368622 16324872 12193738 19684199 23640035 17894541 15322207 17266442 25216247 CAT CXCL8 FGF2 IL12B IL1B IL4 IL6 MMP9 TNF
Diabetes Mellitus, Experimental	25.03	References/Inference Genes References Inference genes 19478208 24513509 21963884 12123627 22191573 15855331 21757225 20709041 21340626 22138235 23499715 20388520 12193562 14871415 CAT FGF21 ICAM1 IFNG IL1B IL6 MMP9 MPO SERPINE1 TNF
Leishmaniasis, Cutaneous	24.77	References/Inference Genes References Inference genes 9234779 20102417 8154019 CXCL8 IFNG IL10 IL1B IL4 TNF
Autism	24.37	References/Inference Genes References Inference genes 8964908 16289943 18929414 18821008 18207134 16360218 15205966 19360663 CAT GABRA1 GABRA3 IFNG IL10 IL2 IL4 IL6 NTF3 PRL SERPINE1
Colitis	23.34	References/Inference Genes References Inference genes 22410118 19617644 19238344 24314293 21807089 23810507 24548422 22119709 GHRL IFNG IL10 IL1B IL4 IL6 MPO TNF
Neoplasm Metastasis	23.26	References/Inference Genes References Inference genes 21942447 21209944 17105418 19487542 26984758 22580338 6224980 12538496 23548910 18930813 23431386 8032535 16475674 12748951 23518002 15659795 21937440 CAT HRH2 HSPA1A IL18 IL2 IL6 MAPK1 MAPK3 MMP1 MMP9 TNF
Visceral leishmaniasis	23.13	References/Inference Genes References Inference genes 15716043 1901333 7854095 17404324 22461696 7554475 CXCL8 IFNG IL10 IL1B IL6 TNF
Glomerulonephritis	22.97	References/Inference Genes References Inference genes 1825860 9403216 10910440 18462998 CXCL8 IFNG IL10 IL18 IL1B IL2 IL6 TNF
Arthritis, Experimental	22.85	References/Inference Genes References Inference genes 22450443 19330884 10444273 7589090 9598899 19203382 20131233 21452922 20974942 19765281 CAT IFNG IL10 IL1B IL4 IL6 MPO TNF
Oral Submucous Fibrosis	22.79	References/Inference Genes References Inference genes 16311067 FGF2 IFNG MMP1 MMP9 TNF
Wounds and Injuries	21.74	References/Inference Genes References Inference genes 11842932 21192278 CXCL1 FGF2 ICAM1 IL6 MPO TNF

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Famotidine

Definition

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Famotidine Interacts with Diseases

Famotidine Interacts with Genes

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