Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic, via CYP3A4 and CYP2E1. Half Life: 53 hours
- Uses/Sources: For the treatment of petit mal epilepsy.
- Health Effects: May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease.
- Symptoms: Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression.
- Treatment: Treatment should include emesis (unless the patient is or could rapidly become obtunded, comatose, or convulsing) or gastric lavage, activated charcoal, cathartics, and general supportive measures. Hemodialysis may be useful to treat ethosuximide overdose. Forced diuresis and exchange transfusions are ineffective. (L1712)
- Route of Exposure: Bioavailability following oral administration is 93%.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Voltage-dependent T-type calcium channel subunit alpha-1I Histamine H1 receptor |
18817368 6146381 |
|
Voltage-dependent T-type calcium channel subunit alpha-1G | Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. |
11752352 |
Ethosuximide Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Lymphoma, Mantle-Cell | 18.3 |
|
Adenocarcinoma | 14.06 |
|
Prostatic Neoplasms | 11.26 |
|
Colonic neoplasm | 10.76 |
|
Cecal Neoplasms | 10.26 |
|
Medulloblastoma | 10.04 |
|
Uterine Cervical Neoplasms | 9.93 |
|
Stomach Neoplasms | 9.36 |
|
Liver Neoplasms | 9.35 |
|
Intestinal Polyps | 9.03 |
|
Hepatocellular carcinoma | 8.95 |
|
Aberrant Crypt Foci | 8.87 |
|
Esophageal Neoplasms | 8.22 |
|
Colorectal cancer | 8.08 |
|
Adenoma | 7.97 |
|
Carcinoma, Non-Small-Cell Lung | 7.32 |
|
Mammary Neoplasms, Animal | 7.12 |
|
Hemangiosarcoma | 7.01 |
|
Intestinal Neoplasms | 6.94 |
|
Caudal Duplication Anomaly | 6.66 |
|