ETHINYL ESTRADIOL | SelfDecode

Definition

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. A synthetic form of estradiol, called ethinyl estradiol is a major component of hormonal contraceptive devices.

Description

A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives . Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.

Top Gene Interactions

Related Pathways

General Information

Metabolism: Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens. Half Life: 36 +/- 13 hours
Uses/Sources: For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
Symptoms: Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Route of Exposure: Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Toxicity

Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
Toxicity: Oral, mouse LD<sub>50</sub>: 1737 mg/kg.

Mechanism of Action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Target Name	Mechanism of Action	References
Estrogen receptor Glucocorticoid receptor Estrogen receptor beta Androgen receptor Progesterone receptor Cytochrome P450 3A5 Nuclear receptor subfamily 1 group I member 2 Sodium-dependent serotonin transporter Sodium-dependent dopamine transporter Translocator protein Sodium-dependent noradrenaline transporter Cytochrome P450 2C9 Cytochrome P450 2C19 Nuclear receptor subfamily 1 group I member 3 Cytochrome P450 2C18 Cytochrome P450 2J2 Bile acid receptor		23611293

Ethinyl Estradiol Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Liver Cirrhosis, Experimental	440.98	References/Inference Genes References Inference genes 23798564 15095483 12609069 15793283 15057751 16025519 16465399 15745444 25380136 17565644 16579972 16688825 18637143 26435214 18458672 18221819 15772939 16627068 12389079 17963606 15370692 16609999 15591519 18416461 12586293 15362042 15996030 17127702 17072980 15492853 15623374 12632514 12667390 16097045 12918455 15650968 14724832 16085334 16097051 16610050 16508911 16953842 21163135 16549783 15197228 26739621 16116963 12557150 16126171 18466260 18263696 10677585 16642209 17714472 18251166 16552806 23341968 18555214 11788567 17347453 18380797 16511523 26806094 18376398 14716496 16610064 16570350 18054572 16539848 15942678 A2M ABAT ABCB1 ABCC2 ABCC5 ABCG1 ABCG5 ABCG8 ACAT1 ACP5 ACTA2 ACTN1 ADA ADAM17 ADD3 ADGRE1 ADH4 ADIPOQ ADM AFP AGFG1 AGT AHNAK AIF1 AKTIP ALB ALDH1A1 ALDH1L1 ANGPTL3 ANXA1 ANXA2 ANXA3 ANXA4 ANXA5 APOA4 APP AQP7 AS1 ASAH1 ASNS ATF3 ATP10D ATRN BDH1 BICD2 BIRC3 BLVRA BMP7 C1QA CA3 CASP7 CAV1 CCL2 CCL5 CCNB2 CCNG1 CD36 CD38 CD48 CD53 CD68 CD83 CD86 CDH5 CDK1 CDKN1A CDKN3 CDO1 CELF2 CLEC4F CLIC1 CLP1 COL12A1 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COL5A1 COL5A2 COL6A1 COL6A2 COLEC12 CRY1 CRYAB CTGF CTSS CTSZ CXCL1 CXCL12 CXCL9 CYBA CYP17A1 CYP1A2 CYP26A1 DDC DHRS3 DHRS7 DIO1 DOCK10 DYSF EDN1 EGF ELOVL5 EMB ENPP2 EPB41L2 EPCAM EZR FABP2 FAT1 FBN1 FBXO9 FGF2 FHL1 FMO1 FOS FSTL1 GALC GBP2 GC GCK GHR GJA1 GLS2 GNA14 GOT1 GPAM GPNMB GPT GRN GSTA2 GSTA3 GSTM1 HAL HAO2 HELLS HGF HIP1 HMGCR HMOX1 HPSE HSD17B6 ID2 ID4 IFNG IFNGR1 IFRD1 IGF1 IGF2BP3 IGF2R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP7 IL10 IL18 IL1B INHBC INHBE INMT INPP5D INS INSIG2 ISG20 ISYNA1 ITGB2 ITGB3 ITGB6 IVD KLF6 KNG1 KRT8 KTN1 LBP LCP1 LEP LGALS1 LGALS3 LGMN LIMK2 LOX LPL LPXN LRAT LRRFIP1 LTB LTBP1 LUM LY86 MAP3K8 MEOX2 MGAT5 MGP MKI67 MMP1 MMP2 MMP8 MMP9 MT1A MYC NAGK NAT8 NCKAP1L NCOR2 NDRG1 NEK6 NFE2L2 NFKBIA NFKBIZ NID2 NOS2 NOS3 NR0B2 NT5E OAT OLFML3 OTC PALMD PAMR1 PC PCK1 PDGFRA PDGFRB PFKP PKLR PLAT PLEKHB1 PLG PLOD2 PLTP POMC PRKCB PRLR PRNP PROCR PSMB10 PSMB8 PSMB9 PSME2 PTGER2 PTGS1 PTGS2 PTN PTPN1 PTPRC PTPRD PTPRO RAB30 RAB31 RAB8B RAMP1 RARRES1 RCN1 RDH10 RGS2 RGS5 RTN4 S100A10 S100A6 SEMA6D SERPINA6 SERPINA7 SERPINB9 SERPINH1 SKAP2 SLC25A13 SLC37A4 SLC39A6 SLC39A8 SMAD4 SMC2 SMOC1 SOCS1 SOCS2 SOX4 SRD5A1 SREBF1 SRGN STAC3 SULT2A1 TAGLN2 TCF4 TGFB1 TGFB3 TGFBR2 THBD TMEM43 TNF TNFAIP8 TPM1 TRAFD1 TRIB3 TSC22D1 TSPAN8 TUSC3 VAV1 VEGFA VIM WFDC2 WLS XPNPEP2 YWHAZ
Prostatic Neoplasms	216.94	References/Inference Genes References Inference genes 16442593 17016690 15341671 17785557 17332283 19223546 17929269 17196171 19593445 16908180 20140206 16106254 17486273 16934689 16552752 25735316 19396168 17542986 17646272 16172807 26005866 25246272 23441843 15616829 25062956 18056468 17609663 18454446 18559593 15318950 17148459 15389811 17639508 16516039 16859836 14968442 24586243 18355840 16427044 23315858 16421604 17363613 19503093 20347977 12210481 18381416 11196146 24500903 17085659 23248098 14666681 17728788 16434975 17823934 10753955 16220300 23704919 16783571 16496412 12445681 19074884 15948133 16606632 17003774 14754878 9371490 16158739 17199135 15046698 17916567 15790600 12610512 21801027 12893367 17909013 17173048 17704407 20564326 18500220 21671747 21714127 14975756 15042602 17914592 15643194 25908785 12429631 17999153 17013881 17695467 14973119 25320179 14997205 23936228 18073375 17141945 19082440 16458450 17363566 16949795 15538743 22581815 16813949 22919386 15496535 17202838 17220347 14973106 15126378 16434482 22666205 18304461 19011039 16733517 16921512 17634423 17465223 17592021 16114055 17606477 22159333 21946351 16809448 17115417 21716162 18306354 20932324 25415046 12783936 20875869 17507624 16537705 12644816 12727815 19283074 18798265 18264097 16465378 15999119 21903722 16284379 19208208 17585057 16000583 17132221 16931574 16984552 15764345 20729295 25485837 15682402 11275366 17465268 22610119 21456062 17919073 19240160 18174250 16266977 12237244 16424004 17409433 19081794 18676866 17288544 16998812 24028178 16406883 17196815 24763052 20052738 18082198 17826523 17136230 11742035 15598783 15302576 15583422 17220348 15386377 17566973 16877366 18829485 16506214 16166285 15672864 25970160 15342424 22564066 17688413 18264096 25237833 15159307 20124447 17176215 26443449 16340751 12592389 17875733 20676098 ABCC4 ABCG5 ACE ADRB2 AGR2 AHR AKT1 ALAD ALDH1A2 ANXA1 ANXA3 ANXA4 AOX1 APEX1 APPL2 ATF3 AZGP1 BAD BAX BAZ2A BCL2 BGLAP BMP7 BMPR1B BRAF BRCA1 BRCA2 CALR CASP9 CAV1 CBR1 CBX1 CCND1 CCND2 CDH1 CDH13 CDKN1A CDKN1B CLDN7 CLU CNN3 COMT CRYAB CRYL1 CST6 CTBP2 CTNNB1 CTSB CTSD CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP2C19 CYP3A4 CYP3A5 CYP7B1 DAB2IP DAG1 DNMT1 EFEMP2 EGF EGFR EGR1 EIF2AK2 EIF3H ELAC2 EPCAM EPHX1 EPS8L3 ERBB3 ERCC2 ERP44 ESR1 ESR2 EZH2 EZR FAF2 FBLN1 FBLN5 FBXO44 FGF2 FOXP4 GALNT3 GGT1 GHR GJA1 GNMT GOLGA4 GRB7 GREB1 GSK3B GSTA1 GSTM1 GSTM3 GSTO1 GSTP1 HBG1 HIP1 HMOX1 HPGD HPN HSD17B1 HSD17B3 HSD3B1 HSD3B2 HSP90B1 HSPA1A ID3 IGF1 IGFBP3 IGFBP7 IL10 IL18 IL1RN IL2 IL27 IL6 INS ITGB3 ITPR1 IVNS1ABP KLF15 KLF6 KLK2 KLK3 LBA LEP LIFR LPAR1 LPL LRP2 LXR M6PR MAD1L1 MAPK3 MC2R MDM2 MIF MIF1 MMP9 MPO MSH3 MSR1 MTAP MUC4 MXI1 MYC NAGK NBN NCOA1 NCOA2 NDRG1 NFE2L2 NFIC NGFR NOS3 NQO1 NR3C1 NRP1 NUCB2 OLFM1 PARP1 PDHA1 PDIA3 PDZK1 PENK PHGDH PLAUR PODXL PON1 PPARA PPFIBP2 PRKACB PRKCZ PRNP PSMC3IP PTEN PTGS2 RASD1 RNF130 RPN2 RUNX1 RXRA SERPINE1 SERPINF1 SHBG SLC26A4 SLC31A1 SOD2 SPINK1 SPON2 SRD5A1 SSBP2 STARD10 STAT3 SULT1A1 SULT2A1 TBXAS1 TCN2 TGFA TGFB1 TGFBR2 TIRAP TLR6 TMPRSS2 TMSB4X TOP2A TP53 TPD52 TPT1 TST TUSC3 UCK2 UCP3 UMPS VAV3 VDR VEGFA VIM WNT4 XRCC1
Stomach Neoplasms	119.44	References/Inference Genes References Inference genes 16314833 1733439 19168852 25847246 10404093 17003101 15723263 17171786 12588804 21471434 21133646 10874023 14503839 12107286 21105199 22285823 15138205 17387271 17571247 22385256 18059164 21936542 10853026 15378696 22644300 21347786 24816255 16134180 23593346 23382965 17355264 17224647 15448013 10072428 22039417 18593901 24816253 11397402 9537325 19424620 25279216 16367923 22484628 21173787 22037551 21364753 17009404 14647439 22414649 21458988 16912530 15492468 17089033 19184424 21750908 26558449 19584167 15993841 18652704 16609701 22452940 22042947 22490514 26098866 21628965 15201584 ACAD8 ACE ACTC1 ADRB1 ADRB2 AFP AGTR2 AHR ALB ALDH7A1 ALDOB ANXA5 APEX1 APOA1 AURKB BIRC5 BMP2 BMP7 CA2 CAV1 CCND1 CD44 CDH1 CDH2 CDK4 CDKN1A CDKN1B CKB CLCN3 CTNNA2 CTSC DNMT1 DPAGT1 ECHS1 EGFR ENO1 ERCC1 ERCC2 FADS1 FBP1 FGFR2 FGG FST GSTP1 HMOX1 HRAS HSPB1 HSPD1 ID4 IGFBP3 IGFBP7 IL1B IL1RN IL6 IL6R ING1 JUN KLF6 KRAS KRT8 LGALS3 M6PR MAPK1 MAPK3 MAPK8 MARK1 MMP10 MMP7 MRPL13 MSLN MTSS1 MUC1 MUTYH MX1 MYC NDUFS1 NOS3 NT5E PA2G4 PDHA1 PHB POLR3K PPIC PRKAA1 PRKCB PRNP PTGS2 RANBP10 RARB RARRES1 RBP1 RBP4 RGS2 RHOA RORA RPL15 RPL18 RUNX3 SELENBP1 SERBP1 SERPINA1 SERPINE1 SLC1A2 SMAD4 SNAI1 SNX5 SOD2 STAT3 SUCLG1 TBX3 TFAP2C TGFA THBD TIMP3 TNF TP53 TRAP1 TYMP UMPS WIF1 XRCC1 XRCC3 ZBTB20 ZNRD1
Breast carcinoma	116.29	References/Inference Genes References Inference genes 23921149 22520950 17474063 11850205 20354179 20961995 21638049 21942447 17570480 26437033 17388661 23001124 25330770 25753200 15341671 19238537 19681904 19913079 10930538 25078270 17520698 17529973 15894690 7894491 12839489 18283316 19434490 9407957 10788334 18509974 18949741 20061804 16077979 20400965 16298037 21353530 16597321 18511948 11325840 18497072 23867902 22038807 19151563 20179234 21466612 20197467 22296396 16818634 18066063 16175315 19639193 16391819 11583189 21057462 18438407 20135347 15802278 16792888 9309585 19020767 21633166 19685490 18507500 23064031 16127422 17285134 25038754 19671875 19602265 23839043 16968874 16618760 19075277 15958052 23180569 19636701 22204715 17965603 20104649 20103631 18521742 22174584 18492817 16854221 15375496 19552798 25322848 17426702 19288272 26379698 16870006 20531310 14975756 25267515 20421688 21515334 19330030 19839049 20458558 20234815 23624423 22572619 19385967 17092400 19968660 14672398 16322251 17255770 21679465 26192916 21501481 20228224 25751625 15496535 22892281 15750629 25151356 19579870 19234134 21804546 19548127 12006526 16244791 17516992 23621182 18498876 24185510 19617202 19776672 15631943 19446661 18398872 16234514 17260099 26124351 17417639 26629949 21903722 23548910 17132221 16583263 23146280 20453838 21463514 18925433 21489049 20941507 19756960 17297925 15455371 16954440 26229107 21781528 12810669 16280049 12165863 22531848 19652463 16255778 18768436 24014025 23342035 17043665 22311042 17520682 17595805 20332317 25688741 12839951 19671742 19435922 21936542 19655245 12023982 17529967 22614657 16950593 18488158 15706428 23535733 20948315 16799634 20562527 24185512 20135344 22267197 19436038 16904380 19115204 21036696 21098263 15609129 17659439 23289900 12592389 12517783 ABCB1 ABCC1 ABCG2 ABL1 ACTA2 ADAMTS1 AFP AGR2 AHR AKAP12 AKT1 AKT2 ALDOA ANGPTL4 BAX BCL2 BIRC5 BMP2 BMP4 BRCA1 BRCA2 CASP7 CAT CAV1 CCND1 CCNE1 CCT5 CDH1 CDH5 CDKN1B CFL1 CHEK1 CLIC1 CLUL1 CNR2 COL7A1 COMT CPT1A CSF1 CSF2 CST6 CTNNB1 CXCL12 CXCL2 CXCL9 CXCR4 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP24A1 CYP3A4 DAP3 DHFR DKK1 DNMT1 DNMT3A E2F1 EDNRB EFEMP1 EGF EGFR EIF2S2 EIF6 ELK3 ENO1 EPB41L3 ERBB3 ESR1 ESR2 ETS2 EVL EXO1 EZH2 FGF3 FGFR2 FKBPL FLT1 FN1 FOS FOXP3 FST GDF10 GPNMB GPX1 GRB7 GSTP1 H2AFX HEYL HHEX HMOX1 HP HPSE HRAS HRG HSP90AA1 IDO1 IFNG IGF1 IGF1R IGFBP5 IGFBP7 IL1B IL6 JAG1 JAG2 JUN KDR KIT KRAS KRT14 KRT5 KRT8 LBA LEP LEPR LPAR1 LSP1 MAP3K1 MDM2 MDM4 MIF MKI67 MMP1 MMP14 MMP2 MMP-3 MMP9 MRPL13 MRPL19 MTR NCOA1 NCOA2 NDRG1 NDUFS3 NFKBIA NOS2 NOS3 NOTCH1 NOTCH2 NOTCH3 NQO1 NRIP1 PABPC1 PAK1 PARP1 PDZK1 PGR PHB PHGDH PIM1 PIN1 PPARGC1B PRC1 PTEN PTGS1 PTGS2 PTPRD RAD51B RARA RARB RB1 REPS2 RGS2 SERPINB5 SETBP1 SETD2 SFRP1 SFRP2 SHMT1 SLC2A1 SLC2A2 SLC39A6 SNAI1 SOD2 SPP1 STAT3 STAT5A STC2 SYNE1 SYNJ2 TBX3 TFRC TGM2 THBS1 TNF TOP2A TOX3 TP53 TRERF1 UMPS VDR VIM XRCC3 ZEB1
Mammary Neoplasms, Animal	115.62	References/Inference Genes References Inference genes 14522882 22248470 16316942 9879772 15609129 6280079 8185828 11137312 20235097 8603490 18424824 12376462 21489049 12606953 15637090 12203372 17173897 14633621 ACTB ACTN4 ALCAM ANXA1 ANXA2 ANXA4 AQP1 AS1 BRCA1 CAPZB CCND1 CCNH CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COMT COX1 DBI EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS HRAS ID3 ID4 INSIG1 KITLG KNG1 KRT5 LPL MGP MIF MPZL1 NDN PADI4 PEBP1 PGR PHB PKM PPARA PRL PRLR PSMA4 PTN RAN RB1 RBP1 RBP4 RCN1 RPL6 RPS14 S100A6 S100A8 SCARB1 SGK1 SLC25A10 SOX9 STAT3 STAT5A TF TKT TSC22D1 UCP2 VAMP8 XDH YWHAZ
Mammary Neoplasms, Experimental	105.14	References/Inference Genes References Inference genes 14522882 16619500 17584969 15217511 12606953 15637090 23964924 8185828 24809783 8603490 15318939 16322315 14999141 16316942 9879772 11137312 21080969 12203372 12376462 22767648 11376698 14633621 21283680 15528971 15609129 25221644 2523869 16319139 8389152 ABCG2 ACTB ACTN4 AFP AGTR2 ALCAM ANXA1 ANXA4 AQP1 AS1 BRCA1 CAPZB CCND1 CCNH CD44 CDC42 CDH1 CDK4 CDK6 CDS1 CNN3 COL5A1 COX1 DBI EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS HMOX1 HRAS ID3 ID4 IGF1 IL10 INSIG1 KITLG KRT5 LPL MGP MIF MMP9 MPZL1 NCOA1 PADI4 PEBP1 PGR PHB PKM PPARA PRL PRLR PSMA4 PTK2 PTN RAN RB1 RBP1 RBP4 RCN1 RNPEP RPL6 RPS14 S100A6 SCARB1 SGK1 SLC25A10 SOD2 SOX9 SPP1 STAT3 STAT5A TF TFF1 TKT TSC22D1 UCP2 VAMP8 XDH XRCC3 YWHAZ
Carcinoma	100.77	References/Inference Genes References Inference genes 14522882 11053990 9326929 17450239 10545420 12606953 15637090 16061637 21332314 17520682 8185828 10789724 10853026 24816255 16316942 12417722 15302576 9879772 12565868 11137312 12203372 12376462 8075649 20565773 17173897 9626339 2228319 14633621 10485483 21458988 11103787 11605069 21489049 11196146 10426811 12189197 ABCB1 ACTB ACTN4 ALCAM ANGPTL4 ANXA1 ANXA4 AQP1 AS1 BCL2 BRCA1 CAPZB CCND1 CCNH CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COX1 CSF2 DBI DNMT1 EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS GSTP1 HRAS ID3 ID4 INSIG1 KITLG KRAS KRT5 LPL MGP MIF MPZL1 MYC NDN PADI4 PEBP1 PGR PHB PKM PLAUR PPARA PRLR PSMA4 PTEN PTGS1 PTGS2 PTN RAN RB1 RBP1 RBP4 RCN1 RHOA RPL6 RPS14 S100A6 SCARB1 SGK1 SLC25A10 SOD2 SOX9 STAT3 STAT5A TF TGFB1 TGFBR2 TKT TP53 TSC22D1 TYMP UCP2 VAMP8 VHL XDH YWHAZ
Endometriosis	91.46	References/Inference Genes References Inference genes 11925390 17625110 21063030 18815356 23284138 20864642 21958689 22138541 23183084 21048224 19407222 21232532 25446850 23104006 ABCC4 ABCC9 ACTA2 ARNT BMP7 BRD8 CD55 CXCL14 CYB5A CYP19A1 CYP26A1 DIO2 DKK1 DUSP1 EGFR ENPP1 ERRFI1 ESR2 FBLN1 FBN1 FKBP5 FOS GREB1 HDAC1 HDAC2 HSD17B1 IDO1 IFNGR1 IGF1 IGFBP1 IHH IL15 KLF13 KLF9 KRAS LAMB1 LMOD1 LTF MAOB NCOA1 NEDD4L NR1D2 NR2F2 NR3C1 NR4A1 NRP1 OLFM4 PGR PRL PRLR PTGER2 PTGER4 PTGFR PTGS2 RARB RASGRP1 RBPJ SLC1A1 SLC40A1 SMPDL3A SPARCL1 SRD5A1 SST STC2 SUCLG2 SULF2 TACSTD2 TAGLN TGFB2 THRA TNC
Hepatocellular carcinoma	82.23	References/Inference Genes References Inference genes 16086872 18230555 11286481 18553387 15509519 19229483 19514085 19731237 16831601 18026104 12060674 16328049 19363144 8200073 9932610 7892276 25822088 19146867 12203361 18477611 20084675 20214788 9311599 22039417 12532445 11872629 22488367 17510421 15341023 23242368 14578863 15057872 21056497 16092956 8033108 17615358 20514400 17191126 21472284 25496033 20698225 16284949 21147110 8364915 22922871 16374840 9207284 25109342 22634754 18666234 22634756 24012840 15565109 27022031 23811326 18425332 11896611 21499249 12771043 18559595 27222248 12024111 19919837 21785164 17978847 22649188 22675488 20118494 19436114 9029167 16767786 14961299 6258829 14563831 23958494 2885971 2821104 20818158 26189965 12029619 18760346 16698587 17441810 15276417 21147764 17363595 18639551 11563603 22561517 22022477 16288022 16799960 A2M ABCB1 ACACA ACE ACOX1 ACTB ADAMTS1 ADD1 AFP ANXA4 APCS APEX1 APOA1 ARID1B BIRC5 BRAF C9 CA2 CBR1 CCND1 CCNE1 CCR1 CDH13 CDK14 CDK4 CDKN1B CEBPA CEBPB COMT CP CRP CTNNB1 CTSD CXCL12 CYP17A1 CYP1A1 E2F1 EGF EGFR EIF3H ENO1 EPHX1 ESR1 F2 FABP5 FBP1 FDFT1 FGF3 FOS FST GJB1 GLUL GNMT GPC3 GSTM1 GSTP1 HGF HHIP HMGCR HRAS HSD3B2 HSPA5 HSPA9 HSPB1 HTATIP2 IGF1R IGF2 IGF2R IL6 ITIH3 JUN KRAS LBA MAT1A ME1 MLXIPL MMP2 MMP9 MPO MT1A MTOR MYC NFE2L2 NFKBIA NME1 NR0B2 NR1H4 OCA PCK1 PDIA3 PGD PHB PKM PTEN PTGS2 PTK2 PYGL RARA RB1 RRM2 SERPINA1 SLC2A1 SLC2A2 SOCS3 SOD2 SREBF1 STAT1 STAT4 TAGLN2 TALDO1 TGFA TGFB1 TNF TP53 TSC1 TST UCHL1 UMPS USP2 VCAM1
Disease Progression	81.21	References/Inference Genes References Inference genes 22294766 10566621 19385967 12082015 21638049 11283936 21794976 22547077 20618948 10673208 21750559 21479221 25078270 22204715 23876460 21749277 22321834 20104649 12644816 20627363 20170495 22488367 21364753 18930813 22287159 20859196 23146280 20729295 19839049 16081686 ABCA7 ABCB1 ABCC1 ABCF1 ABCF2 ACAD8 ALDH7A1 APEX1 BCL2 CAT CCNE1 CDH1 CDH2 CGA CLCN3 CTSB CTSC DDX58 DPAGT1 EGF EGFR EPHA2 ERBB3 ESR1 FGF2 FLT1 GSTP1 HRAS ING1 KLK3 M6PR MMP2 MRPL13 MYC NDUFS1 OCA PA2G4 PDHA1 PHB POLR3K PRDX4 PTEN RANBP10 RPL15 RPL18 SERBP1 SNX5 SOD2 SOD3 STAT1 SUCLG1 TOP2A TRAP1 ZEB1
Colorectal cancer	76.94	References/Inference Genes References Inference genes 19671906 22294766 12907644 23202126 15954165 21369707 18413743 24836286 16144935 18084292 17575224 18718023 18998757 17923031 18435490 19020767 19509152 16879199 18507500 17934461 23548910 17656264 17187072 16524972 17389618 7705931 18483336 23431386 12837940 17892325 15289873 18949393 10965019 18267032 25701956 10853026 12645814 15731169 12637750 21081473 23354438 27222248 15753380 23263490 21930798 20346928 21946351 16110022 20878130 16963246 26053496 10072428 15706408 21291235 15814641 15172127 21544799 18829568 18716850 25280562 20565773 19011631 16364925 10485483 21892161 21278247 23977225 20427397 16111806 23922874 20593958 18372905 11375891 17949449 16331619 18676755 17047489 ABCA6 ABCB1 ABCB10 ABCB11 ABCC1 ABCC2 ABCC4 ABCC5 ABCG1 ABCG2 AKT1 ARNT BCL2 BIRC5 BMP4 BRAF BUB1B CALR CCND1 CDH1 CDH5 CFTR COL7A1 CSF2 CTNNB1 CYP1A2 CYP1B1 DCLK1 DHFR EFEMP1 EGFR EIF3H ERCC2 ESR2 EVL EXO1 FADS1 FADS2 FAT1 FBLN2 FBN2 FEN1 FGFR3 FLCN FLNC FOXL2 FPGS GATA4 GNB4 GPNMB GSTM1 GSTM3 IGF2 IGFBP3 JPH3 KDR KRAS MDR1 MKI67 MMP1 MMP2 MSH2 NAMPT NME1 NME2 NQO1 OCA ODC1 POLD1 POLE POSTN PPP1R14A PRKCB PRKCE PROM1 PTGS2 PTPRD PTPRJ RET RRM2 SCG5 SELENBP1 SERPINB5 SFRP1 SFRP2 SLC19A1 SMAD4 SMAD7 SOD2 SOX17 SYNE1 TCF7L2 TCN2 TFRC TGFB1 TLR2 TNF TP53 TXNRD1 TYMP UMPS VTI1A WIF1
Obesity	73.89	References/Inference Genes References Inference genes 26655953 11528401 23839791 19153526 18334666 24497646 20716455 25222487 20882379 2777199 19913045 9502777 11782876 20561897 20667977 17229951 11328671 16325777 17405841 22276206 20869355 23819014 23349936 19103437 10900012 17628001 27020609 23954404 19079261 22537059 23834033 14617771 18344982 3519326 17517446 24042701 21156398 18375438 8923850 25086370 25551525 21786805 15687340 19270708 15592485 20122948 11381268 16317704 26186301 9826672 9202122 25554529 20975297 20956498 20567778 10744717 16289378 22484627 23563609 24263156 17062801 15494731 20141834 22841818 10092513 18515891 18604207 11089532 23956348 15184668 19171794 12032746 ACACB ACADM ACP5 ADIPOQ ADRB1 ADRB2 ADRB3 AHR AKT1 ALDH1L1 APOE AQP7 AS1 CA3 COX7C CRP CS CTSS CYB5A CYCS CYP26B1 ECHS1 ENPP1 ESR1 ETFDH F2 FAAH FOXO3 GLUL GNPDA2 GPX1 HADH HK2 HMOX1 HOXB5 HSD11B1 HSPA5 IDO1 IGF2 IGFBP2 IL6 INS KCTD15 LBP LDLR LEP LEPR LPL ME1 MMP9 MTCH2 MUT NAMPT NPY1R NQO1 NR0B2 NR1I2 NR1I3 NTRK2 PACS1 PARP1 PCK1 PCSK1 PFKFB3 POMC PPARA PPARGC1B PRKAR2B PRKCH PTGS2 PTPN1 SAT1 SDC3 SERPINE1 SH2B1 SIRT3 SLC22A1 SOD1 SOD2 SREBF1 STS SUCLG2 TF TFRC TNF TNFRSF1B UCP1 UCP2 UCP3 VLDLR
Myocardial Ischemia	71.62	References/Inference Genes References Inference genes 10462014 16306806 16286589 16214533 14583313 15347709 11707688 9554809 14503966 16155579 12447174 11840375 12354446 10908253 9860779 16775501 12173832 15746188 ACTB ADIPOQ ADRB1 ADRB2 AGT ALDOA BHLHE40 CALR CCL2 CCND1 CCND2 CD36 CD38 CDH2 CPT1B CRP CTSC CXCL2 DCN DLAT DUSP1 EDN1 FABP5 FGF2 GBP2 GCH1 GHR GSTA1 GSTP1 HGF HIVEP2 HK1 HK2 HMGB1 HMGCS2 HMOX1 HSPA1A HSPA9 ID3 IFNGR1 IGF1 IGFBP3 IL1A IL1B IL6 KDR KITLG KLF4 MAP3K8 MEOX2 MX1 NCL NEDD4 NFKBIA NOS3 NR4A1 PDHA1 PEBP1 PFKFB3 PFKM PGM1 POMC PPM1B PPP3R1 PRKCE RXRG SLC6A6 SLC8A1 SOCS3 SOD2 STAT5A SULT1A1 TFRC TMED2 TMPO TNF TXNRD1 VCAM1 VEGFA ZEB1
Autism	66.28	References/Inference Genes References Inference genes 12579522 16139734 21082655 17597297 27082637 14755447 16027737 18621663 15471876 17383819 25961944 20663923 22490277 15446388 20157312 17626784 20442744 16721604 16360218 17199132 15363659 18207134 21328570 18676531 17380209 11706102 18057082 17347881 15992526 17264841 18053270 18929414 21359227 19211884 18270976 18492799 11496368 16520824 18563708 20649385 19365831 12032595 11354825 11803234 20662941 20375269 18759867 18348195 25217958 15892143 17292328 21310003 17893705 16297937 15288368 17280648 16917939 18435417 17322880 18067135 8098541 19360663 17033973 11317216 20468076 18579107 15046869 20531469 16946189 8964908 17203304 17290275 15830322 16027742 19195803 15820235 16724005 15523497 19265751 9804340 17376794 15694999 20452682 9152989 11814262 14659996 17404132 15056512 17883863 8570775 19167832 18179894 15108192 17547689 19221690 20071347 16472391 15205966 ABAT ACADSB ACE ADA ADM ADRB2 ADSL ASIC2 AVPR1A BCL2 C4B CADPS2 CAT CENTG2 CHRNA4 CHRNB2 CNTN3 CNTNAP2 COMT CP CYP19A1 DHCR7 DHFR DLGAP2 EGF EXT1 FOXP2 GHR GJA1 GPX1 GSTM1 GSTP1 HDLBP HRAS HTR5A IFNG IGF1 IGF2 IGFBP3 IL10 IL15 IL1RN IL2 IL4 IL5 IL6 ITGB3 KCNMA1 LAMB1 LASP1 LBA LEP MAOB MARK1 MIF MTF1 NOS2 NRXN1 NTRK2 OXTR PER1 PITX1 PLAUR POMC PON1 PRKCB PRL PRLR PTEN PTGS2 REEP3 RELN RIMS1 RNF8 ROBO1 ROBO4 RORA SCAMP5 SCN7A SERPINE1 SLC19A1 SLC1A3 SLC25A12 SLC40A1 SLC6A4 SNTG2 ST8SIA2 STXBP6 SYNGAP1 TAF1C TCN2 TDO2 TF TNFRSF1B TSC1 VLDLR XDH XPC ZMYND11
Rheumatoid arthritis	64.07	References/Inference Genes References Inference genes 20080907 23333834 19192274 2001072 20476861 22450443 19898480 23143596 3874814 22104130 23897011 16055108 18617548 18794853 20008919 26001728 17568789 15292528 20453841 12566094 16368150 12833524 22446963 8391952 1568518 16597321 19898481 7706905 24313545 20453842 16385501 16729287 11978490 16872482 17379860 19193698 ABCB1 ABCC2 ABCC4 ABCC5 ABCG2 ADIPOQ AGER AHR ANXA3 ARID5B ATIC BAIAP2L1 BMP4 BMP6 CALD1 CAT CCL8 CCR6 CD83 CDK6 CP CRP CSF2 CTGF CTSD CXCL2 CXCR4 DDIT4 DDX6 DFNA5 DHFR ENO1 F2 FKBP5 FOXP3 FPGS GART GC GPRC5A HSD11B1 IFNG IGFBP3 IL10 IL18 IL1B IL1RN IL6 IL6R IRAK1 IRF5 ITGA6 MARCKS MIF MMEL1 MMP10 MMP12 MMP2 MPO NFKBIL1 NOXA PADI4 PON1 PRDM1 PTGS2 PTK2 PTPN2 PTPRC PXK RASGRP1 RBPJ RUNX1 SLC11A1 SLC25A12 SOD2 STAT1 STAT4 STS TLR2 TMPO TNF TNFAIP2 TNFRSF11B TYK2 VEGFA
Mesothelioma, Malignant	61.8	References/Inference Genes References Inference genes 11453316 23621518 26678224 20682992 25756049 16850164 22784439 23435014 16697254 19190155 25162674 27032653 26928227 20617513 23056237 26463840 26818092 21543585 ANXA2 APOA1 BCL2 C9 CCL5 CCL7 CDK6 CDKN1A COL12A1 CSF1 CTNNB1 CXCL12 CXCL9 EFEMP1 EGFR EPHX1 FGF9 FN1 FTH1 GSTM1 HEPH HGF IFNG IGF2BP3 IL1A IL4 IL6 KIT MDK MIF MSLN MUC1 NF2 NGF OPG PARP1 PDPN RXRA SDC1 SETD2 SETDB1 SLC22A5 SLC2A1 SMARCA2 SOD2 TF TFDP2 TGFB2 TP53 ULK2 VIM
Esophageal squamous cell carcinoma	59.72	References/Inference Genes References Inference genes 18167182 25151357 21517111 18691855 15375580 23644492 16639733 11641616 16543248 18197933 21947696 21206495 21969086 15756444 ABCC2 ADCYAP1 ANXA1 BUB1B CA2 CALR CAPZA1 CCND1 CDKN1A CFL1 CLIC1 EGFR FAT1 GSTO1 HMGB1 HSPA5 KRT13 KRT14 KRT17 MAD2L1 NFE2L2 NOTCH1 NOTCH2 NOTCH3 PRDX1 PSME2 PTGS2 RB1 SLC39A6 SOD2 TAGLN TNFAIP8 TP53 TPM1 TYMP XRCC1
HIV Infections	56.39	References/Inference Genes References Inference genes 15308739 17187345 12878215 12646808 16903978 17448989 16597321 10202824 ALB APOA1 ARAP3 BAG3 BAX BIRC3 CCL11 CCL2 CCR3 CCT3 CCT5 CDC42 CDKN1A CLIC1 CXCL12 CXCR1 EIF6 HDGF HP HSP90AA1 HSPA9 HSPB1 HSPD1 HSPH1 IFNG IL10 IL2 ILF2 KPNB1 LYN MDM2 ODC1 PRPF8 PSMA4 PSMA5 PSMA6 PSMB10 PSMB4 PSMC3