ETHINYL ESTRADIOL | SelfDecode

Definition

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. A synthetic form of estradiol, called ethinyl estradiol is a major component of hormonal contraceptive devices.

Description

A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives . Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.

Top Gene Interactions

Related Pathways

General Information

Metabolism: Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens. Half Life: 36 +/- 13 hours
Uses/Sources: For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
Symptoms: Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Route of Exposure: Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Toxicity

Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
Toxicity: Oral, mouse LD<sub>50</sub>: 1737 mg/kg.

Mechanism of Action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Target Name	Mechanism of Action	References
Estrogen receptor Glucocorticoid receptor Estrogen receptor beta Androgen receptor Progesterone receptor Cytochrome P450 3A5 Nuclear receptor subfamily 1 group I member 2 Sodium-dependent serotonin transporter Sodium-dependent dopamine transporter Translocator protein Sodium-dependent noradrenaline transporter Cytochrome P450 2C9 Cytochrome P450 2C19 Nuclear receptor subfamily 1 group I member 3 Cytochrome P450 2C18 Cytochrome P450 2J2 Bile acid receptor		23611293

Ethinyl Estradiol Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Liver Cirrhosis, Experimental	440.98	References/Inference Genes References Inference genes 18054572 16642209 12609069 17963606 23798564 15772939 15095483 18251166 16552806 16549783 18380797 18466260 17565644 18263696 16025519 15996030 15362042 15623374 26806094 16097051 18376398 26435214 25380136 17347453 16465399 16627068 15492853 16953842 16688825 18637143 12667390 16116963 12586293 12557150 15650968 15745444 15197228 16511523 16570350 16609999 17072980 12918455 17127702 16097045 16508911 15942678 18458672 16579972 11788567 14716496 15370692 12632514 12389079 21163135 16610050 18416461 15793283 17714472 16126171 16085334 16539848 15057751 23341968 18555214 15591519 16610064 14724832 18221819 10677585 26739621 A2M ABAT ABCB1 ABCC2 ABCC5 ABCG1 ABCG5 ABCG8 ACAT1 ACP5 ACTA2 ACTN1 ADA ADAM17 ADD3 ADGRE1 ADH4 ADIPOQ ADM AFP AGFG1 AGT AHNAK AIF1 AKTIP ALB ALDH1A1 ALDH1L1 ANGPTL3 ANXA1 ANXA2 ANXA3 ANXA4 ANXA5 APOA4 APP AQP7 AS1 ASAH1 ASNS ATF3 ATP10D ATRN BDH1 BICD2 BIRC3 BLVRA BMP7 C1QA CA3 CASP7 CAV1 CCL2 CCL5 CCNB2 CCNG1 CD36 CD38 CD48 CD53 CD68 CD83 CD86 CDH5 CDK1 CDKN1A CDKN3 CDO1 CELF2 CLEC4F CLIC1 CLP1 COL12A1 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COL5A1 COL5A2 COL6A1 COL6A2 COLEC12 CRY1 CRYAB CTGF CTSS CTSZ CXCL1 CXCL12 CXCL9 CYBA CYP17A1 CYP1A2 CYP26A1 DDC DHRS3 DHRS7 DIO1 DOCK10 DYSF EDN1 EGF ELOVL5 EMB ENPP2 EPB41L2 EPCAM EZR FABP2 FAT1 FBN1 FBXO9 FGF2 FHL1 FMO1 FOS FSTL1 GALC GBP2 GC GCK GHR GJA1 GLS2 GNA14 GOT1 GPAM GPNMB GPT GRN GSTA2 GSTA3 GSTM1 HAL HAO2 HELLS HGF HIP1 HMGCR HMOX1 HPSE HSD17B6 ID2 ID4 IFNG IFNGR1 IFRD1 IGF1 IGF2BP3 IGF2R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP7 IL10 IL18 IL1B INHBC INHBE INMT INPP5D INS INSIG2 ISG20 ISYNA1 ITGB2 ITGB3 ITGB6 IVD KLF6 KNG1 KRT8 KTN1 LBP LCP1 LEP LGALS1 LGALS3 LGMN LIMK2 LOX LPL LPXN LRAT LRRFIP1 LTB LTBP1 LUM LY86 MAP3K8 MEOX2 MGAT5 MGP MKI67 MMP1 MMP2 MMP8 MMP9 MT1A MYC NAGK NAT8 NCKAP1L NCOR2 NDRG1 NEK6 NFE2L2 NFKBIA NFKBIZ NID2 NOS2 NOS3 NR0B2 NT5E OAT OLFML3 OTC PALMD PAMR1 PC PCK1 PDGFRA PDGFRB PFKP PKLR PLAT PLEKHB1 PLG PLOD2 PLTP POMC PRKCB PRLR PRNP PROCR PSMB10 PSMB8 PSMB9 PSME2 PTGER2 PTGS1 PTGS2 PTN PTPN1 PTPRC PTPRD PTPRO RAB30 RAB31 RAB8B RAMP1 RARRES1 RCN1 RDH10 RGS2 RGS5 RTN4 S100A10 S100A6 SEMA6D SERPINA6 SERPINA7 SERPINB9 SERPINH1 SKAP2 SLC25A13 SLC37A4 SLC39A6 SLC39A8 SMAD4 SMC2 SMOC1 SOCS1 SOCS2 SOX4 SRD5A1 SREBF1 SRGN STAC3 SULT2A1 TAGLN2 TCF4 TGFB1 TGFB3 TGFBR2 THBD TMEM43 TNF TNFAIP8 TPM1 TRAFD1 TRIB3 TSC22D1 TSPAN8 TUSC3 VAV1 VEGFA VIM WFDC2 WLS XPNPEP2 YWHAZ
Prostatic Neoplasms	216.94	References/Inference Genes References Inference genes 23248098 17085659 17826523 15389811 16921512 16434482 17585057 16813949 18454446 15999119 21714127 21671747 16783571 16516039 17785557 17148459 17919073 19011039 23441843 20676098 18829485 18306354 16606632 15790600 22159333 17542986 20875869 15672864 15598783 17141945 15764345 19081794 17823934 21946351 14973119 17909013 20124447 16000583 19503093 17288544 16284379 17363613 24500903 15302576 15386377 17363566 15341671 15583422 18500220 16406883 16552752 17639508 19396168 12210481 17132221 17465268 17688413 11275366 12445681 18798265 17609663 25735316 17196815 17929269 14973106 15682402 15318950 17003774 17016690 26005866 17695467 16537705 21456062 17566973 12592389 18381416 16166285 17409433 17196171 16465378 16908180 18304461 12727815 17486273 21903722 14666681 16158739 19223546 25237833 14997205 17136230 15948133 25246272 16949795 17914592 12237244 17173048 17728788 17592021 24028178 16266977 16934689 9371490 17332283 22666205 16106254 17875733 16172807 15046698 25908785 17202838 16427044 15126378 19240160 21801027 16340751 20564326 20729295 18264097 15643194 16733517 16984552 20052738 17606477 20932324 16458450 17220347 18073375 25062956 14754878 16877366 15616829 18264096 19082440 18676866 19593445 26443449 20140206 17916567 16809448 17013881 15496535 11196146 15538743 23936228 18082198 14968442 17176215 25320179 16220300 14975756 15159307 19074884 19283074 22610119 15342424 12429631 16859836 22564066 17507624 20347977 17220348 22919386 24763052 22581815 21716162 16931574 16434975 16114055 15042602 12644816 23704919 17115417 17199135 23315858 17634423 19208208 17646272 17999153 24586243 18355840 12610512 11742035 10753955 16424004 25415046 16442593 12783936 16496412 12893367 18559593 18174250 17465223 17704407 25485837 16998812 16421604 25970160 18056468 16506214 ABCC4 ABCG5 ACE ADRB2 AGR2 AHR AKT1 ALAD ALDH1A2 ANXA1 ANXA3 ANXA4 AOX1 APEX1 APPL2 ATF3 AZGP1 BAD BAX BAZ2A BCL2 BGLAP BMP7 BMPR1B BRAF BRCA1 BRCA2 CALR CASP9 CAV1 CBR1 CBX1 CCND1 CCND2 CDH1 CDH13 CDKN1A CDKN1B CLDN7 CLU CNN3 COMT CRYAB CRYL1 CST6 CTBP2 CTNNB1 CTSB CTSD CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP2C19 CYP3A4 CYP3A5 CYP7B1 DAB2IP DAG1 DNMT1 EFEMP2 EGF EGFR EGR1 EIF2AK2 EIF3H ELAC2 EPCAM EPHX1 EPS8L3 ERBB3 ERCC2 ERP44 ESR1 ESR2 EZH2 EZR FAF2 FBLN1 FBLN5 FBXO44 FGF2 FOXP4 GALNT3 GGT1 GHR GJA1 GNMT GOLGA4 GRB7 GREB1 GSK3B GSTA1 GSTM1 GSTM3 GSTO1 GSTP1 HBG1 HIP1 HMOX1 HPGD HPN HSD17B1 HSD17B3 HSD3B1 HSD3B2 HSP90B1 HSPA1A ID3 IGF1 IGFBP3 IGFBP7 IL10 IL18 IL1RN IL2 IL27 IL6 INS ITGB3 ITPR1 IVNS1ABP KLF15 KLF6 KLK2 KLK3 LBA LEP LIFR LPAR1 LPL LRP2 LXR M6PR MAD1L1 MAPK3 MC2R MDM2 MIF MIF1 MMP9 MPO MSH3 MSR1 MTAP MUC4 MXI1 MYC NAGK NBN NCOA1 NCOA2 NDRG1 NFE2L2 NFIC NGFR NOS3 NQO1 NR3C1 NRP1 NUCB2 OLFM1 PARP1 PDHA1 PDIA3 PDZK1 PENK PHGDH PLAUR PODXL PON1 PPARA PPFIBP2 PRKACB PRKCZ PRNP PSMC3IP PTEN PTGS2 RASD1 RNF130 RPN2 RUNX1 RXRA SERPINE1 SERPINF1 SHBG SLC26A4 SLC31A1 SOD2 SPINK1 SPON2 SRD5A1 SSBP2 STARD10 STAT3 SULT1A1 SULT2A1 TBXAS1 TCN2 TGFA TGFB1 TGFBR2 TIRAP TLR6 TMPRSS2 TMSB4X TOP2A TP53 TPD52 TPT1 TST TUSC3 UCK2 UCP3 UMPS VAV3 VDR VEGFA VIM WNT4 XRCC1
Stomach Neoplasms	119.44	References/Inference Genes References Inference genes 14503839 22414649 26558449 1733439 15492468 10404093 18059164 21133646 22490514 16134180 19424620 21936542 10072428 21105199 17089033 21471434 16609701 16314833 21347786 15448013 17171786 19184424 23382965 17009404 22042947 17003101 21173787 23593346 26098866 24816255 21458988 15723263 11397402 16912530 22644300 21750908 18652704 10853026 24816253 17571247 15138205 18593901 22037551 10874023 16367923 25279216 21364753 14647439 21628965 15201584 12107286 22039417 17355264 17224647 25847246 22484628 17387271 19168852 22285823 22385256 9537325 15993841 22452940 12588804 19584167 15378696 ACAD8 ACE ACTC1 ADRB1 ADRB2 AFP AGTR2 AHR ALB ALDH7A1 ALDOB ANXA5 APEX1 APOA1 AURKB BIRC5 BMP2 BMP7 CA2 CAV1 CCND1 CD44 CDH1 CDH2 CDK4 CDKN1A CDKN1B CKB CLCN3 CTNNA2 CTSC DNMT1 DPAGT1 ECHS1 EGFR ENO1 ERCC1 ERCC2 FADS1 FBP1 FGFR2 FGG FST GSTP1 HMOX1 HRAS HSPB1 HSPD1 ID4 IGFBP3 IGFBP7 IL1B IL1RN IL6 IL6R ING1 JUN KLF6 KRAS KRT8 LGALS3 M6PR MAPK1 MAPK3 MAPK8 MARK1 MMP10 MMP7 MRPL13 MSLN MTSS1 MUC1 MUTYH MX1 MYC NDUFS1 NOS3 NT5E PA2G4 PDHA1 PHB POLR3K PPIC PRKAA1 PRKCB PRNP PTGS2 RANBP10 RARB RARRES1 RBP1 RBP4 RGS2 RHOA RORA RPL15 RPL18 RUNX3 SELENBP1 SERBP1 SERPINA1 SERPINE1 SLC1A2 SMAD4 SNAI1 SNX5 SOD2 STAT3 SUCLG1 TBX3 TFAP2C TGFA THBD TIMP3 TNF TP53 TRAP1 TYMP UMPS WIF1 XRCC1 XRCC3 ZBTB20 ZNRD1
Breast carcinoma	116.29	References/Inference Genes References Inference genes 19288272 19839049 25753200 17388661 26229107 15706428 23624423 21936542 20531310 10788334 15894690 19434490 22204715 20332317 20104649 18925433 26124351 20458558 17965603 22296396 20234815 18497072 19681904 16792888 17285134 25330770 11325840 21489049 17520698 20103631 19636701 16077979 21466612 19075277 19234134 20948315 23535733 19552798 21098263 22614657 15341671 15455371 21638049 21057462 20400965 21501481 21679465 19671742 16322251 16391819 9407957 19115204 16854221 17132221 23621182 20197467 17092400 16904380 21633166 23548910 20179234 12165863 15958052 25322848 21804546 12592389 18511948 16968874 17043665 19330030 21903722 24014025 19655245 25267515 9309585 19151563 12810669 16234514 21036696 25751625 26192916 25151356 26437033 19671875 19385967 16954440 23146280 19548127 19639193 23001124 18507500 18768436 17426702 25078270 26379698 20354179 17297925 17520682 22038807 18521742 15750629 18492817 17255770 19602265 12839489 15802278 16244791 16618760 19238537 16175315 19435922 16950593 23064031 7894491 12006526 19446661 21353530 15496535 19913079 12839951 17529973 22520950 19652463 20061804 20961995 14672398 14975756 17474063 21463514 16818634 19617202 20135347 17417639 24185510 18066063 20453838 10930538 16870006 19968660 24185512 23921149 16127422 23342035 17659439 23839043 18398872 19436038 12023982 11850205 15375496 22572619 18509974 16597321 20135344 16280049 26629949 25688741 22892281 15631943 20941507 12517783 22267197 22311042 23867902 18498876 19756960 16583263 20421688 11583189 15609129 17595805 16255778 17516992 25038754 21942447 22531848 17570480 20562527 19020767 17529967 23289900 19685490 17260099 23180569 21781528 20228224 21515334 18283316 19776672 18438407 19579870 22174584 16799634 18949741 16298037 18488158 ABCB1 ABCC1 ABCG2 ABL1 ACTA2 ADAMTS1 AFP AGR2 AHR AKAP12 AKT1 AKT2 ALDOA ANGPTL4 BAX BCL2 BIRC5 BMP2 BMP4 BRCA1 BRCA2 CASP7 CAT CAV1 CCND1 CCNE1 CCT5 CDH1 CDH5 CDKN1B CFL1 CHEK1 CLIC1 CLUL1 CNR2 COL7A1 COMT CPT1A CSF1 CSF2 CST6 CTNNB1 CXCL12 CXCL2 CXCL9 CXCR4 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP24A1 CYP3A4 DAP3 DHFR DKK1 DNMT1 DNMT3A E2F1 EDNRB EFEMP1 EGF EGFR EIF2S2 EIF6 ELK3 ENO1 EPB41L3 ERBB3 ESR1 ESR2 ETS2 EVL EXO1 EZH2 FGF3 FGFR2 FKBPL FLT1 FN1 FOS FOXP3 FST GDF10 GPNMB GPX1 GRB7 GSTP1 H2AFX HEYL HHEX HMOX1 HP HPSE HRAS HRG HSP90AA1 IDO1 IFNG IGF1 IGF1R IGFBP5 IGFBP7 IL1B IL6 JAG1 JAG2 JUN KDR KIT KRAS KRT14 KRT5 KRT8 LBA LEP LEPR LPAR1 LSP1 MAP3K1 MDM2 MDM4 MIF MKI67 MMP1 MMP14 MMP2 MMP-3 MMP9 MRPL13 MRPL19 MTR NCOA1 NCOA2 NDRG1 NDUFS3 NFKBIA NOS2 NOS3 NOTCH1 NOTCH2 NOTCH3 NQO1 NRIP1 PABPC1 PAK1 PARP1 PDZK1 PGR PHB PHGDH PIM1 PIN1 PPARGC1B PRC1 PTEN PTGS1 PTGS2 PTPRD RAD51B RARA RARB RB1 REPS2 RGS2 SERPINB5 SETBP1 SETD2 SFRP1 SFRP2 SHMT1 SLC2A1 SLC2A2 SLC39A6 SNAI1 SOD2 SPP1 STAT3 STAT5A STC2 SYNE1 SYNJ2 TBX3 TFRC TGM2 THBS1 TNF TOP2A TOX3 TP53 TRERF1 UMPS VDR VIM XRCC3 ZEB1
Mammary Neoplasms, Animal	115.62	References/Inference Genes References Inference genes 6280079 8603490 8185828 15609129 16316942 12376462 20235097 15637090 21489049 9879772 12203372 14633621 14522882 11137312 22248470 17173897 18424824 12606953 ACTB ACTN4 ALCAM ANXA1 ANXA2 ANXA4 AQP1 AS1 BRCA1 CAPZB CCND1 CCNH CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COMT COX1 DBI EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS HRAS ID3 ID4 INSIG1 KITLG KNG1 KRT5 LPL MGP MIF MPZL1 NDN PADI4 PEBP1 PGR PHB PKM PPARA PRL PRLR PSMA4 PTN RAN RB1 RBP1 RBP4 RCN1 RPL6 RPS14 S100A6 S100A8 SCARB1 SGK1 SLC25A10 SOX9 STAT3 STAT5A TF TKT TSC22D1 UCP2 VAMP8 XDH YWHAZ
Mammary Neoplasms, Experimental	105.14	References/Inference Genes References Inference genes 22767648 15637090 15318939 14522882 16619500 23964924 8185828 16316942 21283680 14999141 16319139 8603490 11376698 15609129 12376462 12203372 9879772 14633621 17584969 8389152 11137312 15217511 21080969 15528971 12606953 16322315 2523869 25221644 24809783 ABCG2 ACTB ACTN4 AFP AGTR2 ALCAM ANXA1 ANXA4 AQP1 AS1 BRCA1 CAPZB CCND1 CCNH CD44 CDC42 CDH1 CDK4 CDK6 CDS1 CNN3 COL5A1 COX1 DBI EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS HMOX1 HRAS ID3 ID4 IGF1 IL10 INSIG1 KITLG KRT5 LPL MGP MIF MMP9 MPZL1 NCOA1 PADI4 PEBP1 PGR PHB PKM PPARA PRL PRLR PSMA4 PTK2 PTN RAN RB1 RBP1 RBP4 RCN1 RNPEP RPL6 RPS14 S100A6 SCARB1 SGK1 SLC25A10 SOD2 SOX9 SPP1 STAT3 STAT5A TF TFF1 TKT TSC22D1 UCP2 VAMP8 XDH XRCC3 YWHAZ
Carcinoma	100.77	References/Inference Genes References Inference genes 10789724 15637090 10485483 17520682 14522882 10545420 20565773 24816255 11103787 8185828 17450239 16316942 21458988 12417722 11053990 8075649 9626339 2228319 10853026 17173897 11605069 12189197 10426811 12376462 21489049 12203372 9879772 11196146 12565868 14633621 11137312 16061637 21332314 12606953 9326929 15302576 ABCB1 ACTB ACTN4 ALCAM ANGPTL4 ANXA1 ANXA4 AQP1 AS1 BCL2 BRCA1 CAPZB CCND1 CCNH CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COX1 CSF2 DBI DNMT1 EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS GSTP1 HRAS ID3 ID4 INSIG1 KITLG KRAS KRT5 LPL MGP MIF MPZL1 MYC NDN PADI4 PEBP1 PGR PHB PKM PLAUR PPARA PRLR PSMA4 PTEN PTGS1 PTGS2 PTN RAN RB1 RBP1 RBP4 RCN1 RHOA RPL6 RPS14 S100A6 SCARB1 SGK1 SLC25A10 SOD2 SOX9 STAT3 STAT5A TF TGFB1 TGFBR2 TKT TP53 TSC22D1 TYMP UCP2 VAMP8 VHL XDH YWHAZ
Endometriosis	91.46	References/Inference Genes References Inference genes 23104006 21048224 21958689 17625110 22138541 18815356 23183084 19407222 21063030 21232532 20864642 11925390 23284138 25446850 ABCC4 ABCC9 ACTA2 ARNT BMP7 BRD8 CD55 CXCL14 CYB5A CYP19A1 CYP26A1 DIO2 DKK1 DUSP1 EGFR ENPP1 ERRFI1 ESR2 FBLN1 FBN1 FKBP5 FOS GREB1 HDAC1 HDAC2 HSD17B1 IDO1 IFNGR1 IGF1 IGFBP1 IHH IL15 KLF13 KLF9 KRAS LAMB1 LMOD1 LTF MAOB NCOA1 NEDD4L NR1D2 NR2F2 NR3C1 NR4A1 NRP1 OLFM4 PGR PRL PRLR PTGER2 PTGER4 PTGFR PTGS2 RARB RASGRP1 RBPJ SLC1A1 SLC40A1 SMPDL3A SPARCL1 SRD5A1 SST STC2 SUCLG2 SULF2 TACSTD2 TAGLN TGFB2 THRA TNC
Hepatocellular carcinoma	82.23	References/Inference Genes References Inference genes 12029619 25822088 14961299 12532445 20818158 22649188 17441810 19514085 25496033 16767786 7892276 23958494 22634754 18425332 21147110 17363595 15057872 12060674 14563831 18639551 16328049 11896611 21785164 24012840 21056497 16831601 16086872 8033108 11286481 17191126 18666234 18559595 16799960 16288022 16284949 15509519 20118494 23811326 9932610 9207284 20084675 22039417 17510421 19363144 18230555 15341023 19436114 21499249 19731237 25109342 18026104 23242368 12203361 12771043 22561517 21147764 20514400 15565109 20698225 9029167 15276417 22488367 11872629 8364915 18553387 14578863 19146867 12024111 11563603 17978847 18477611 18760346 19229483 16374840 21472284 16698587 27222248 16092956 19919837 17615358 22634756 27022031 2885971 22675488 9311599 22922871 2821104 22022477 8200073 20214788 26189965 6258829 A2M ABCB1 ACACA ACE ACOX1 ACTB ADAMTS1 ADD1 AFP ANXA4 APCS APEX1 APOA1 ARID1B BIRC5 BRAF C9 CA2 CBR1 CCND1 CCNE1 CCR1 CDH13 CDK14 CDK4 CDKN1B CEBPA CEBPB COMT CP CRP CTNNB1 CTSD CXCL12 CYP17A1 CYP1A1 E2F1 EGF EGFR EIF3H ENO1 EPHX1 ESR1 F2 FABP5 FBP1 FDFT1 FGF3 FOS FST GJB1 GLUL GNMT GPC3 GSTM1 GSTP1 HGF HHIP HMGCR HRAS HSD3B2 HSPA5 HSPA9 HSPB1 HTATIP2 IGF1R IGF2 IGF2R IL6 ITIH3 JUN KRAS LBA MAT1A ME1 MLXIPL MMP2 MMP9 MPO MT1A MTOR MYC NFE2L2 NFKBIA NME1 NR0B2 NR1H4 OCA PCK1 PDIA3 PGD PHB PKM PTEN PTGS2 PTK2 PYGL RARA RB1 RRM2 SERPINA1 SLC2A1 SLC2A2 SOCS3 SOD2 SREBF1 STAT1 STAT4 TAGLN2 TALDO1 TGFA TGFB1 TNF TP53 TSC1 TST UCHL1 UMPS USP2 VCAM1
Disease Progression	81.21	References/Inference Genes References Inference genes 19839049 22294766 20729295 25078270 18930813 22204715 21794976 20104649 21749277 22488367 12644816 12082015 21750559 22547077 10673208 20627363 10566621 21364753 20618948 23876460 22321834 20170495 22287159 20859196 16081686 21479221 19385967 11283936 21638049 23146280 ABCA7 ABCB1 ABCC1 ABCF1 ABCF2 ACAD8 ALDH7A1 APEX1 BCL2 CAT CCNE1 CDH1 CDH2 CGA CLCN3 CTSB CTSC DDX58 DPAGT1 EGF EGFR EPHA2 ERBB3 ESR1 FGF2 FLT1 GSTP1 HRAS ING1 KLK3 M6PR MMP2 MRPL13 MYC NDUFS1 OCA PA2G4 PDHA1 PHB POLR3K PRDX4 PTEN RANBP10 RPL15 RPL18 SERBP1 SNX5 SOD2 SOD3 STAT1 SUCLG1 TOP2A TRAP1 ZEB1
Colorectal cancer	76.94	References/Inference Genes References Inference genes 18949393 17187072 18507500 15172127 18676755 22294766 18483336 16364925 16144935 11375891 15753380 12837940 15814641 16111806 12907644 10485483 7705931 15289873 18998757 18372905 10072428 19011631 10965019 25701956 20565773 18829568 18084292 18267032 18435490 16963246 16879199 17047489 20346928 18413743 20427397 23548910 17934461 21930798 19671906 23431386 12637750 26053496 23977225 10853026 23202126 21544799 21369707 21291235 21946351 20878130 16331619 17949449 23922874 21892161 18716850 12645814 25280562 21081473 19020767 15954165 15706408 20593958 18718023 24836286 17389618 27222248 21278247 16110022 23263490 16524972 15731169 17656264 23354438 17892325 17575224 19509152 17923031 ABCA6 ABCB1 ABCB10 ABCB11 ABCC1 ABCC2 ABCC4 ABCC5 ABCG1 ABCG2 AKT1 ARNT BCL2 BIRC5 BMP4 BRAF BUB1B CALR CCND1 CDH1 CDH5 CFTR COL7A1 CSF2 CTNNB1 CYP1A2 CYP1B1 DCLK1 DHFR EFEMP1 EGFR EIF3H ERCC2 ESR2 EVL EXO1 FADS1 FADS2 FAT1 FBLN2 FBN2 FEN1 FGFR3 FLCN FLNC FOXL2 FPGS GATA4 GNB4 GPNMB GSTM1 GSTM3 IGF2 IGFBP3 JPH3 KDR KRAS MDR1 MKI67 MMP1 MMP2 MSH2 NAMPT NME1 NME2 NQO1 OCA ODC1 POLD1 POLE POSTN PPP1R14A PRKCB PRKCE PROM1 PTGS2 PTPRD PTPRJ RET RRM2 SCG5 SELENBP1 SERPINB5 SFRP1 SFRP2 SLC19A1 SMAD4 SMAD7 SOD2 SOX17 SYNE1 TCF7L2 TCN2 TFRC TGFB1 TLR2 TNF TP53 TXNRD1 TYMP UMPS VTI1A WIF1
Obesity	73.89	References/Inference Genes References Inference genes 25551525 20567778 20882379 17229951 25554529 20716455 20561897 17062801 18344982 23349936 24263156 20122948 17405841 14617771 27020609 19270708 21786805 20869355 16317704 8923850 3519326 16325777 22841818 2777199 18515891 15592485 22276206 24042701 25222487 19171794 18604207 17628001 24497646 22537059 23956348 21156398 18334666 15494731 20975297 10744717 19913045 23563609 16289378 26655953 10092513 11328671 19153526 9826672 23834033 25086370 17517446 9502777 23819014 20956498 19103437 19079261 23954404 20141834 12032746 20667977 11528401 23839791 15184668 18375438 22484627 11782876 15687340 26186301 11381268 9202122 11089532 10900012 ACACB ACADM ACP5 ADIPOQ ADRB1 ADRB2 ADRB3 AHR AKT1 ALDH1L1 APOE AQP7 AS1 CA3 COX7C CRP CS CTSS CYB5A CYCS CYP26B1 ECHS1 ENPP1 ESR1 ETFDH F2 FAAH FOXO3 GLUL GNPDA2 GPX1 HADH HK2 HMOX1 HOXB5 HSD11B1 HSPA5 IDO1 IGF2 IGFBP2 IL6 INS KCTD15 LBP LDLR LEP LEPR LPL ME1 MMP9 MTCH2 MUT NAMPT NPY1R NQO1 NR0B2 NR1I2 NR1I3 NTRK2 PACS1 PARP1 PCK1 PCSK1 PFKFB3 POMC PPARA PPARGC1B PRKAR2B PRKCH PTGS2 PTPN1 SAT1 SDC3 SERPINE1 SH2B1 SIRT3 SLC22A1 SOD1 SOD2 SREBF1 STS SUCLG2 TF TFRC TNF TNFRSF1B UCP1 UCP2 UCP3 VLDLR
Myocardial Ischemia	71.62	References/Inference Genes References Inference genes 16306806 15746188 14503966 12447174 9860779 16775501 16155579 12173832 14583313 16286589 16214533 12354446 11840375 15347709 10908253 9554809 10462014 11707688 ACTB ADIPOQ ADRB1 ADRB2 AGT ALDOA BHLHE40 CALR CCL2 CCND1 CCND2 CD36 CD38 CDH2 CPT1B CRP CTSC CXCL2 DCN DLAT DUSP1 EDN1 FABP5 FGF2 GBP2 GCH1 GHR GSTA1 GSTP1 HGF HIVEP2 HK1 HK2 HMGB1 HMGCS2 HMOX1 HSPA1A HSPA9 ID3 IFNGR1 IGF1 IGFBP3 IL1A IL1B IL6 KDR KITLG KLF4 MAP3K8 MEOX2 MX1 NCL NEDD4 NFKBIA NOS3 NR4A1 PDHA1 PEBP1 PFKFB3 PFKM PGM1 POMC PPM1B PPP3R1 PRKCE RXRG SLC6A6 SLC8A1 SOCS3 SOD2 STAT5A SULT1A1 TFRC TMED2 TMPO TNF TXNRD1 VCAM1 VEGFA ZEB1
Autism	66.28	References/Inference Genes References Inference genes 17547689 17376794 17322880 17380209 11496368 15694999 17280648 19365831 19221690 20157312 16139734 8964908 20531469 18348195 19195803 18676531 17347881 17203304 17033973 18929414 20375269 18563708 18435417 9152989 27082637 18067135 20662941 8570775 19360663 15056512 15820235 22490277 15830322 21082655 17883863 11706102 14659996 11317216 20071347 17290275 17383819 20452682 16297937 17597297 21328570 17404132 15046869 16721604 11803234 18579107 25217958 9804340 18759867 15205966 17626784 17292328 19211884 15363659 18492799 16917939 16360218 16027737 18207134 15523497 17893705 16472391 19265751 17264841 15471876 16724005 14755447 18057082 18621663 20649385 18053270 21359227 11354825 16946189 15892143 19167832 11814262 25961944 20442744 18179894 15992526 15446388 18270976 12032595 17199132 16520824 20468076 12579522 20663923 16027742 8098541 21310003 15108192 15288368 ABAT ACADSB ACE ADA ADM ADRB2 ADSL ASIC2 AVPR1A BCL2 C4B CADPS2 CAT CENTG2 CHRNA4 CHRNB2 CNTN3 CNTNAP2 COMT CP CYP19A1 DHCR7 DHFR DLGAP2 EGF EXT1 FOXP2 GHR GJA1 GPX1 GSTM1 GSTP1 HDLBP HRAS HTR5A IFNG IGF1 IGF2 IGFBP3 IL10 IL15 IL1RN IL2 IL4 IL5 IL6 ITGB3 KCNMA1 LAMB1 LASP1 LBA LEP MAOB MARK1 MIF MTF1 NOS2 NRXN1 NTRK2 OXTR PER1 PITX1 PLAUR POMC PON1 PRKCB PRL PRLR PTEN PTGS2 REEP3 RELN RIMS1 RNF8 ROBO1 ROBO4 RORA SCAMP5 SCN7A SERPINE1 SLC19A1 SLC1A3 SLC25A12 SLC40A1 SLC6A4 SNTG2 ST8SIA2 STXBP6 SYNGAP1 TAF1C TCN2 TDO2 TF TNFRSF1B TSC1 VLDLR XDH XPC ZMYND11
Rheumatoid arthritis	64.07	References/Inference Genes References Inference genes 24313545 8391952 16368150 16729287 18794853 19193698 26001728 15292528 22446963 16597321 2001072 17568789 23333834 20080907 20453841 23143596 20476861 3874814 19898481 17379860 18617548 22104130 19192274 20008919 16872482 16385501 23897011 16055108 1568518 12833524 22450443 11978490 12566094 7706905 19898480 20453842 ABCB1 ABCC2 ABCC4 ABCC5 ABCG2 ADIPOQ AGER AHR ANXA3 ARID5B ATIC BAIAP2L1 BMP4 BMP6 CALD1 CAT CCL8 CCR6 CD83 CDK6 CP CRP CSF2 CTGF CTSD CXCL2 CXCR4 DDIT4 DDX6 DFNA5 DHFR ENO1 F2 FKBP5 FOXP3 FPGS GART GC GPRC5A HSD11B1 IFNG IGFBP3 IL10 IL18 IL1B IL1RN IL6 IL6R IRAK1 IRF5 ITGA6 MARCKS MIF MMEL1 MMP10 MMP12 MMP2 MPO NFKBIL1 NOXA PADI4 PON1 PRDM1 PTGS2 PTK2 PTPN2 PTPRC PXK RASGRP1 RBPJ RUNX1 SLC11A1 SLC25A12 SOD2 STAT1 STAT4 STS TLR2 TMPO TNF TNFAIP2 TNFRSF11B TYK2 VEGFA
Mesothelioma, Malignant	61.8	References/Inference Genes References Inference genes 25756049 11453316 23621518 16697254 26463840 26928227 16850164 26678224 19190155 21543585 26818092 20617513 20682992 23435014 25162674 27032653 23056237 22784439 ANXA2 APOA1 BCL2 C9 CCL5 CCL7 CDK6 CDKN1A COL12A1 CSF1 CTNNB1 CXCL12 CXCL9 EFEMP1 EGFR EPHX1 FGF9 FN1 FTH1 GSTM1 HEPH HGF IFNG IGF2BP3 IL1A IL4 IL6 KIT MDK MIF MSLN MUC1 NF2 NGF OPG PARP1 PDPN RXRA SDC1 SETD2 SETDB1 SLC22A5 SLC2A1 SMARCA2 SOD2 TF TFDP2 TGFB2 TP53 ULK2 VIM
Esophageal squamous cell carcinoma	59.72	References/Inference Genes References Inference genes 25151357 23644492 16639733 21517111 11641616 15756444 16543248 21206495 18167182 15375580 18691855 18197933 21969086 21947696 ABCC2 ADCYAP1 ANXA1 BUB1B CA2 CALR CAPZA1 CCND1 CDKN1A CFL1 CLIC1 EGFR FAT1 GSTO1 HMGB1 HSPA5 KRT13 KRT14 KRT17 MAD2L1 NFE2L2 NOTCH1 NOTCH2 NOTCH3 PRDX1 PSME2 PTGS2 RB1 SLC39A6 SOD2 TAGLN TNFAIP8 TP53 TPM1 TYMP XRCC1
HIV Infections	56.39	References/Inference Genes References Inference genes 17187345 16597321 17448989 12878215 16903978 12646808 10202824 15308739 ALB APOA1 ARAP3 BAG3 BAX BIRC3 CCL11 CCL2 CCR3 CCT3 CCT5 CDC42 CDKN1A CLIC1 CXCL12 CXCR1 EIF6 HDGF HP HSP90AA1 HSPA9 HSPB1 HSPD1 HSPH1 IFNG IL10 IL2 ILF2 KPNB1