ETHINYL ESTRADIOL | SelfDecode

Definition

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. A synthetic form of estradiol, called ethinyl estradiol is a major component of hormonal contraceptive devices.

Description

A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives . Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.

Top Gene Interactions

Related Pathways

General Information

Metabolism: Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens. Half Life: 36 +/- 13 hours
Uses/Sources: For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
Symptoms: Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Route of Exposure: Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Toxicity

Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
Toxicity: Oral, mouse LD<sub>50</sub>: 1737 mg/kg.

Mechanism of Action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Target Name	Mechanism of Action	References
Estrogen receptor Glucocorticoid receptor Estrogen receptor beta Androgen receptor Progesterone receptor Cytochrome P450 3A5 Nuclear receptor subfamily 1 group I member 2 Sodium-dependent serotonin transporter Sodium-dependent dopamine transporter Translocator protein Sodium-dependent noradrenaline transporter Cytochrome P450 2C9 Cytochrome P450 2C19 Nuclear receptor subfamily 1 group I member 3 Cytochrome P450 2C18 Cytochrome P450 2J2 Bile acid receptor		23611293

Ethinyl Estradiol Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Liver Cirrhosis, Experimental	440.98	References/Inference Genes References Inference genes 26739621 14724832 16552806 15492853 15745444 16579972 16097051 23798564 16642209 16116963 15362042 12667390 16570350 18555214 17714472 12389079 10677585 12609069 16539848 16085334 18416461 15370692 12586293 16511523 15772939 17072980 16097045 11788567 16025519 18637143 15650968 16610050 16465399 16953842 15057751 18376398 15623374 18263696 12557150 15591519 12632514 15996030 16126171 23341968 17565644 16688825 15942678 16627068 17127702 18221819 18458672 25380136 12918455 26435214 17347453 17963606 16609999 18251166 16610064 26806094 18054572 15095483 16549783 15197228 15793283 18380797 14716496 18466260 16508911 21163135 A2M ABAT ABCB1 ABCC2 ABCC5 ABCG1 ABCG5 ABCG8 ACAT1 ACP5 ACTA2 ACTN1 ADA ADAM17 ADD3 ADGRE1 ADH4 ADIPOQ ADM AFP AGFG1 AGT AHNAK AIF1 AKTIP ALB ALDH1A1 ALDH1L1 ANGPTL3 ANXA1 ANXA2 ANXA3 ANXA4 ANXA5 APOA4 APP AQP7 AS1 ASAH1 ASNS ATF3 ATP10D ATRN BDH1 BICD2 BIRC3 BLVRA BMP7 C1QA CA3 CASP7 CAV1 CCL2 CCL5 CCNB2 CCNG1 CD36 CD38 CD48 CD53 CD68 CD83 CD86 CDH5 CDK1 CDKN1A CDKN3 CDO1 CELF2 CLEC4F CLIC1 CLP1 COL12A1 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COL5A1 COL5A2 COL6A1 COL6A2 COLEC12 CRY1 CRYAB CTGF CTSS CTSZ CXCL1 CXCL12 CXCL9 CYBA CYP17A1 CYP1A2 CYP26A1 DDC DHRS3 DHRS7 DIO1 DOCK10 DYSF EDN1 EGF ELOVL5 EMB ENPP2 EPB41L2 EPCAM EZR FABP2 FAT1 FBN1 FBXO9 FGF2 FHL1 FMO1 FOS FSTL1 GALC GBP2 GC GCK GHR GJA1 GLS2 GNA14 GOT1 GPAM GPNMB GPT GRN GSTA2 GSTA3 GSTM1 HAL HAO2 HELLS HGF HIP1 HMGCR HMOX1 HPSE HSD17B6 ID2 ID4 IFNG IFNGR1 IFRD1 IGF1 IGF2BP3 IGF2R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP7 IL10 IL18 IL1B INHBC INHBE INMT INPP5D INS INSIG2 ISG20 ISYNA1 ITGB2 ITGB3 ITGB6 IVD KLF6 KNG1 KRT8 KTN1 LBP LCP1 LEP LGALS1 LGALS3 LGMN LIMK2 LOX LPL LPXN LRAT LRRFIP1 LTB LTBP1 LUM LY86 MAP3K8 MEOX2 MGAT5 MGP MKI67 MMP1 MMP2 MMP8 MMP9 MT1A MYC NAGK NAT8 NCKAP1L NCOR2 NDRG1 NEK6 NFE2L2 NFKBIA NFKBIZ NID2 NOS2 NOS3 NR0B2 NT5E OAT OLFML3 OTC PALMD PAMR1 PC PCK1 PDGFRA PDGFRB PFKP PKLR PLAT PLEKHB1 PLG PLOD2 PLTP POMC PRKCB PRLR PRNP PROCR PSMB10 PSMB8 PSMB9 PSME2 PTGER2 PTGS1 PTGS2 PTN PTPN1 PTPRC PTPRD PTPRO RAB30 RAB31 RAB8B RAMP1 RARRES1 RCN1 RDH10 RGS2 RGS5 RTN4 S100A10 S100A6 SEMA6D SERPINA6 SERPINA7 SERPINB9 SERPINH1 SKAP2 SLC25A13 SLC37A4 SLC39A6 SLC39A8 SMAD4 SMC2 SMOC1 SOCS1 SOCS2 SOX4 SRD5A1 SREBF1 SRGN STAC3 SULT2A1 TAGLN2 TCF4 TGFB1 TGFB3 TGFBR2 THBD TMEM43 TNF TNFAIP8 TPM1 TRAFD1 TRIB3 TSC22D1 TSPAN8 TUSC3 VAV1 VEGFA VIM WFDC2 WLS XPNPEP2 YWHAZ
Prostatic Neoplasms	216.94	References/Inference Genes References Inference genes 16949795 17363613 17606477 17728788 19240160 16813949 21946351 17634423 17196815 15159307 16606632 17875733 16465378 18174250 16998812 17909013 17085659 17688413 15342424 16340751 17115417 19223546 21716162 24763052 15302576 17465268 14968442 16266977 19081794 20564326 24028178 16733517 16552752 25485837 11742035 16114055 16458450 17288544 17914592 14997205 18829485 23704919 12644816 21903722 19208208 12783936 12610512 17542986 20140206 19396168 15948133 22159333 16908180 16434482 16172807 11196146 18082198 18056468 15496535 17202838 15999119 15616829 23936228 16434975 15672864 12893367 20347977 21671747 14666681 15318950 17919073 26443449 16859836 18500220 16284379 25237833 15386377 16421604 19082440 17220348 16537705 21714127 22610119 17148459 19503093 20729295 18676866 15790600 25246272 20124447 18264096 10753955 21801027 16877366 17016690 15126378 12592389 25735316 21456062 17176215 16427044 17916567 17220347 15583422 17646272 23441843 25908785 16158739 14973119 20052738 20932324 17486273 17409433 18355840 17363566 16506214 22666205 11275366 12237244 24586243 16516039 17136230 17592021 18381416 18264097 15598783 17199135 19593445 17003774 16934689 16220300 22581815 25415046 18559593 17566973 17173048 15538743 12445681 16783571 16000583 23315858 15643194 15046698 14975756 15389811 15682402 18304461 24500903 16406883 18798265 17585057 22919386 18306354 25062956 17826523 20676098 16442593 17695467 14973106 19283074 20875869 17132221 18073375 12429631 26005866 25970160 14754878 15764345 17332283 19074884 17141945 16921512 9371490 16984552 17704407 16106254 17013881 17823934 17999153 17929269 17609663 17465223 15042602 16931574 16809448 23248098 15341671 19011039 16496412 12210481 22564066 17785557 18454446 16166285 17507624 17196171 16424004 12727815 17639508 25320179 ABCC4 ABCG5 ACE ADRB2 AGR2 AHR AKT1 ALAD ALDH1A2 ANXA1 ANXA3 ANXA4 AOX1 APEX1 APPL2 ATF3 AZGP1 BAD BAX BAZ2A BCL2 BGLAP BMP7 BMPR1B BRAF BRCA1 BRCA2 CALR CASP9 CAV1 CBR1 CBX1 CCND1 CCND2 CDH1 CDH13 CDKN1A CDKN1B CLDN7 CLU CNN3 COMT CRYAB CRYL1 CST6 CTBP2 CTNNB1 CTSB CTSD CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP2C19 CYP3A4 CYP3A5 CYP7B1 DAB2IP DAG1 DNMT1 EFEMP2 EGF EGFR EGR1 EIF2AK2 EIF3H ELAC2 EPCAM EPHX1 EPS8L3 ERBB3 ERCC2 ERP44 ESR1 ESR2 EZH2 EZR FAF2 FBLN1 FBLN5 FBXO44 FGF2 FOXP4 GALNT3 GGT1 GHR GJA1 GNMT GOLGA4 GRB7 GREB1 GSK3B GSTA1 GSTM1 GSTM3 GSTO1 GSTP1 HBG1 HIP1 HMOX1 HPGD HPN HSD17B1 HSD17B3 HSD3B1 HSD3B2 HSP90B1 HSPA1A ID3 IGF1 IGFBP3 IGFBP7 IL10 IL18 IL1RN IL2 IL27 IL6 INS ITGB3 ITPR1 IVNS1ABP KLF15 KLF6 KLK2 KLK3 LBA LEP LIFR LPAR1 LPL LRP2 LXR M6PR MAD1L1 MAPK3 MC2R MDM2 MIF MIF1 MMP9 MPO MSH3 MSR1 MTAP MUC4 MXI1 MYC NAGK NBN NCOA1 NCOA2 NDRG1 NFE2L2 NFIC NGFR NOS3 NQO1 NR3C1 NRP1 NUCB2 OLFM1 PARP1 PDHA1 PDIA3 PDZK1 PENK PHGDH PLAUR PODXL PON1 PPARA PPFIBP2 PRKACB PRKCZ PRNP PSMC3IP PTEN PTGS2 RASD1 RNF130 RPN2 RUNX1 RXRA SERPINE1 SERPINF1 SHBG SLC26A4 SLC31A1 SOD2 SPINK1 SPON2 SRD5A1 SSBP2 STARD10 STAT3 SULT1A1 SULT2A1 TBXAS1 TCN2 TGFA TGFB1 TGFBR2 TIRAP TLR6 TMPRSS2 TMSB4X TOP2A TP53 TPD52 TPT1 TST TUSC3 UCK2 UCP3 UMPS VAV3 VDR VEGFA VIM WNT4 XRCC1
Stomach Neoplasms	119.44	References/Inference Genes References Inference genes 16609701 16314833 15993841 10874023 25279216 22385256 22490514 21471434 15448013 15492468 11397402 26558449 22285823 16912530 23382965 19168852 21628965 17571247 17003101 17009404 19584167 19424620 18652704 17171786 19184424 21458988 14503839 10404093 10853026 22039417 21133646 14647439 15378696 21105199 10072428 17089033 25847246 22414649 23593346 1733439 17224647 16367923 24816253 24816255 12588804 21347786 15723263 12107286 18593901 26098866 21936542 21173787 15201584 17387271 16134180 18059164 22452940 9537325 22644300 21364753 17355264 22037551 21750908 22484628 15138205 22042947 ACAD8 ACE ACTC1 ADRB1 ADRB2 AFP AGTR2 AHR ALB ALDH7A1 ALDOB ANXA5 APEX1 APOA1 AURKB BIRC5 BMP2 BMP7 CA2 CAV1 CCND1 CD44 CDH1 CDH2 CDK4 CDKN1A CDKN1B CKB CLCN3 CTNNA2 CTSC DNMT1 DPAGT1 ECHS1 EGFR ENO1 ERCC1 ERCC2 FADS1 FBP1 FGFR2 FGG FST GSTP1 HMOX1 HRAS HSPB1 HSPD1 ID4 IGFBP3 IGFBP7 IL1B IL1RN IL6 IL6R ING1 JUN KLF6 KRAS KRT8 LGALS3 M6PR MAPK1 MAPK3 MAPK8 MARK1 MMP10 MMP7 MRPL13 MSLN MTSS1 MUC1 MUTYH MX1 MYC NDUFS1 NOS3 NT5E PA2G4 PDHA1 PHB POLR3K PPIC PRKAA1 PRKCB PRNP PTGS2 RANBP10 RARB RARRES1 RBP1 RBP4 RGS2 RHOA RORA RPL15 RPL18 RUNX3 SELENBP1 SERBP1 SERPINA1 SERPINE1 SLC1A2 SMAD4 SNAI1 SNX5 SOD2 STAT3 SUCLG1 TBX3 TFAP2C TGFA THBD TIMP3 TNF TP53 TRAP1 TYMP UMPS WIF1 XRCC1 XRCC3 ZBTB20 ZNRD1
Breast carcinoma	116.29	References/Inference Genes References Inference genes 20104649 15375496 25330770 20400965 19238537 20961995 17529973 24185510 17092400 17426702 12810669 23001124 19435922 17043665 18498876 16618760 26437033 17417639 15455371 16954440 22572619 17388661 16127422 20562527 19020767 23839043 16968874 9407957 9309585 17297925 16583263 15706428 19434490 22892281 19913079 19756960 17260099 25267515 18521742 15894690 19839049 17965603 20103631 25322848 24014025 20458558 18283316 22311042 19385967 25038754 21515334 21353530 12023982 21903722 17516992 19436038 20941507 10788334 20197467 21679465 15496535 21036696 16950593 16799634 23289900 16298037 16792888 16904380 16255778 16244791 21098263 22531848 23921149 12006526 19548127 20332317 11325840 20135347 22204715 21057462 19671742 15609129 12839951 18492817 19655245 17570480 20948315 14672398 21936542 22520950 18398872 21633166 12165863 19636701 12592389 18507500 21804546 25753200 15802278 19115204 19151563 17285134 19685490 17520682 26629949 12517783 12839489 17520698 16234514 26379698 26229107 19671875 18488158 19446661 19579870 16322251 15958052 17255770 18949741 19617202 16597321 19234134 17659439 20453838 15631943 18768436 19652463 19075277 18066063 10930538 16870006 16391819 26124351 23146280 26192916 20179234 22174584 18497072 23624423 23548910 16280049 19602265 18925433 14975756 22267197 16077979 21781528 19288272 7894491 20135344 21501481 21466612 21638049 18438407 17132221 16818634 22296396 11583189 19330030 19968660 20354179 19681904 18511948 11850205 15750629 23867902 21489049 16175315 17529967 25751625 20234815 21463514 25078270 23621182 19776672 25688741 16854221 22614657 23342035 17474063 20061804 19639193 15341671 20228224 20531310 25151356 24185512 18509974 23180569 19552798 17595805 23064031 23535733 20421688 22038807 21942447 ABCB1 ABCC1 ABCG2 ABL1 ACTA2 ADAMTS1 AFP AGR2 AHR AKAP12 AKT1 AKT2 ALDOA ANGPTL4 BAX BCL2 BIRC5 BMP2 BMP4 BRCA1 BRCA2 CASP7 CAT CAV1 CCND1 CCNE1 CCT5 CDH1 CDH5 CDKN1B CFL1 CHEK1 CLIC1 CLUL1 CNR2 COL7A1 COMT CPT1A CSF1 CSF2 CST6 CTNNB1 CXCL12 CXCL2 CXCL9 CXCR4 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP24A1 CYP3A4 DAP3 DHFR DKK1 DNMT1 DNMT3A E2F1 EDNRB EFEMP1 EGF EGFR EIF2S2 EIF6 ELK3 ENO1 EPB41L3 ERBB3 ESR1 ESR2 ETS2 EVL EXO1 EZH2 FGF3 FGFR2 FKBPL FLT1 FN1 FOS FOXP3 FST GDF10 GPNMB GPX1 GRB7 GSTP1 H2AFX HEYL HHEX HMOX1 HP HPSE HRAS HRG HSP90AA1 IDO1 IFNG IGF1 IGF1R IGFBP5 IGFBP7 IL1B IL6 JAG1 JAG2 JUN KDR KIT KRAS KRT14 KRT5 KRT8 LBA LEP LEPR LPAR1 LSP1 MAP3K1 MDM2 MDM4 MIF MKI67 MMP1 MMP14 MMP2 MMP-3 MMP9 MRPL13 MRPL19 MTR NCOA1 NCOA2 NDRG1 NDUFS3 NFKBIA NOS2 NOS3 NOTCH1 NOTCH2 NOTCH3 NQO1 NRIP1 PABPC1 PAK1 PARP1 PDZK1 PGR PHB PHGDH PIM1 PIN1 PPARGC1B PRC1 PTEN PTGS1 PTGS2 PTPRD RAD51B RARA RARB RB1 REPS2 RGS2 SERPINB5 SETBP1 SETD2 SFRP1 SFRP2 SHMT1 SLC2A1 SLC2A2 SLC39A6 SNAI1 SOD2 SPP1 STAT3 STAT5A STC2 SYNE1 SYNJ2 TBX3 TFRC TGM2 THBS1 TNF TOP2A TOX3 TP53 TRERF1 UMPS VDR VIM XRCC3 ZEB1
Mammary Neoplasms, Animal	115.62	References/Inference Genes References Inference genes 9879772 15609129 8603490 14522882 22248470 18424824 16316942 12376462 20235097 6280079 8185828 12203372 11137312 17173897 21489049 12606953 15637090 14633621 ACTB ACTN4 ALCAM ANXA1 ANXA2 ANXA4 AQP1 AS1 BRCA1 CAPZB CCND1 CCNH CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COMT COX1 DBI EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS HRAS ID3 ID4 INSIG1 KITLG KNG1 KRT5 LPL MGP MIF MPZL1 NDN PADI4 PEBP1 PGR PHB PKM PPARA PRL PRLR PSMA4 PTN RAN RB1 RBP1 RBP4 RCN1 RPL6 RPS14 S100A6 S100A8 SCARB1 SGK1 SLC25A10 SOX9 STAT3 STAT5A TF TKT TSC22D1 UCP2 VAMP8 XDH YWHAZ
Mammary Neoplasms, Experimental	105.14	References/Inference Genes References Inference genes 14522882 16316942 11376698 16322315 8389152 15637090 14633621 9879772 21080969 25221644 14999141 21283680 8185828 8603490 15609129 23964924 24809783 12376462 15318939 16619500 17584969 11137312 12606953 15217511 15528971 16319139 2523869 22767648 12203372 ABCG2 ACTB ACTN4 AFP AGTR2 ALCAM ANXA1 ANXA4 AQP1 AS1 BRCA1 CAPZB CCND1 CCNH CD44 CDC42 CDH1 CDK4 CDK6 CDS1 CNN3 COL5A1 COX1 DBI EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS HMOX1 HRAS ID3 ID4 IGF1 IL10 INSIG1 KITLG KRT5 LPL MGP MIF MMP9 MPZL1 NCOA1 PADI4 PEBP1 PGR PHB PKM PPARA PRL PRLR PSMA4 PTK2 PTN RAN RB1 RBP1 RBP4 RCN1 RNPEP RPL6 RPS14 S100A6 SCARB1 SGK1 SLC25A10 SOD2 SOX9 SPP1 STAT3 STAT5A TF TFF1 TKT TSC22D1 UCP2 VAMP8 XDH XRCC3 YWHAZ
Carcinoma	100.77	References/Inference Genes References Inference genes 14522882 16316942 17520682 9326929 15637090 14633621 9879772 21332314 10426811 8185828 16061637 9626339 17173897 21489049 21458988 8075649 11053990 10853026 10545420 12376462 15302576 24816255 11137312 11605069 12606953 17450239 12417722 12565868 20565773 2228319 10789724 11103787 10485483 12203372 11196146 12189197 ABCB1 ACTB ACTN4 ALCAM ANGPTL4 ANXA1 ANXA4 AQP1 AS1 BCL2 BRCA1 CAPZB CCND1 CCNH CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COX1 CSF2 DBI DNMT1 EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 FURIN GDA GGT1 GSS GSTP1 HRAS ID3 ID4 INSIG1 KITLG KRAS KRT5 LPL MGP MIF MPZL1 MYC NDN PADI4 PEBP1 PGR PHB PKM PLAUR PPARA PRLR PSMA4 PTEN PTGS1 PTGS2 PTN RAN RB1 RBP1 RBP4 RCN1 RHOA RPL6 RPS14 S100A6 SCARB1 SGK1 SLC25A10 SOD2 SOX9 STAT3 STAT5A TF TGFB1 TGFBR2 TKT TP53 TSC22D1 TYMP UCP2 VAMP8 VHL XDH YWHAZ
Endometriosis	91.46	References/Inference Genes References Inference genes 17625110 23183084 22138541 23284138 21232532 20864642 19407222 25446850 21063030 18815356 21048224 11925390 23104006 21958689 ABCC4 ABCC9 ACTA2 ARNT BMP7 BRD8 CD55 CXCL14 CYB5A CYP19A1 CYP26A1 DIO2 DKK1 DUSP1 EGFR ENPP1 ERRFI1 ESR2 FBLN1 FBN1 FKBP5 FOS GREB1 HDAC1 HDAC2 HSD17B1 IDO1 IFNGR1 IGF1 IGFBP1 IHH IL15 KLF13 KLF9 KRAS LAMB1 LMOD1 LTF MAOB NCOA1 NEDD4L NR1D2 NR2F2 NR3C1 NR4A1 NRP1 OLFM4 PGR PRL PRLR PTGER2 PTGER4 PTGFR PTGS2 RARB RASGRP1 RBPJ SLC1A1 SLC40A1 SMPDL3A SPARCL1 SRD5A1 SST STC2 SUCLG2 SULF2 TACSTD2 TAGLN TGFB2 THRA TNC
Hepatocellular carcinoma	82.23	References/Inference Genes References Inference genes 23242368 16831601 16284949 22634754 15276417 22649188 21785164 9207284 9932610 16092956 20698225 26189965 20084675 12771043 9311599 14563831 6258829 12203361 16328049 18639551 21472284 17510421 18425332 18553387 22675488 11563603 20118494 21147110 20214788 12532445 15341023 11286481 20818158 9029167 25496033 16767786 24012840 15565109 22039417 17615358 7892276 27222248 22922871 23958494 20514400 22634756 15509519 18666234 14578863 17441810 18230555 21056497 22488367 17363595 18477611 12024111 16799960 8364915 22561517 21147764 12060674 17191126 11896611 11872629 8200073 19229483 27022031 19514085 18559595 17978847 2821104 2885971 15057872 19731237 19363144 16086872 25109342 22022477 18026104 18760346 16698587 23811326 19436114 19919837 16374840 25822088 8033108 19146867 12029619 14961299 16288022 21499249 A2M ABCB1 ACACA ACE ACOX1 ACTB ADAMTS1 ADD1 AFP ANXA4 APCS APEX1 APOA1 ARID1B BIRC5 BRAF C9 CA2 CBR1 CCND1 CCNE1 CCR1 CDH13 CDK14 CDK4 CDKN1B CEBPA CEBPB COMT CP CRP CTNNB1 CTSD CXCL12 CYP17A1 CYP1A1 E2F1 EGF EGFR EIF3H ENO1 EPHX1 ESR1 F2 FABP5 FBP1 FDFT1 FGF3 FOS FST GJB1 GLUL GNMT GPC3 GSTM1 GSTP1 HGF HHIP HMGCR HRAS HSD3B2 HSPA5 HSPA9 HSPB1 HTATIP2 IGF1R IGF2 IGF2R IL6 ITIH3 JUN KRAS LBA MAT1A ME1 MLXIPL MMP2 MMP9 MPO MT1A MTOR MYC NFE2L2 NFKBIA NME1 NR0B2 NR1H4 OCA PCK1 PDIA3 PGD PHB PKM PTEN PTGS2 PTK2 PYGL RARA RB1 RRM2 SERPINA1 SLC2A1 SLC2A2 SOCS3 SOD2 SREBF1 STAT1 STAT4 TAGLN2 TALDO1 TGFA TGFB1 TNF TP53 TSC1 TST UCHL1 UMPS USP2 VCAM1
Disease Progression	81.21	References/Inference Genes References Inference genes 20104649 16081686 21794976 12082015 22287159 21750559 21638049 23876460 22547077 10673208 20170495 10566621 18930813 11283936 22204715 22321834 20859196 25078270 20729295 20627363 22294766 20618948 23146280 19839049 21749277 21364753 19385967 12644816 21479221 22488367 ABCA7 ABCB1 ABCC1 ABCF1 ABCF2 ACAD8 ALDH7A1 APEX1 BCL2 CAT CCNE1 CDH1 CDH2 CGA CLCN3 CTSB CTSC DDX58 DPAGT1 EGF EGFR EPHA2 ERBB3 ESR1 FGF2 FLT1 GSTP1 HRAS ING1 KLK3 M6PR MMP2 MRPL13 MYC NDUFS1 OCA PA2G4 PDHA1 PHB POLR3K PRDX4 PTEN RANBP10 RPL15 RPL18 SERBP1 SNX5 SOD2 SOD3 STAT1 SUCLG1 TOP2A TRAP1 ZEB1
Colorectal cancer	76.94	References/Inference Genes References Inference genes 17187072 17892325 12645814 23922874 21278247 19509152 23977225 19011631 18718023 16524972 16110022 18084292 21946351 23354438 23263490 21291235 26053496 16364925 17923031 15731169 12907644 21544799 19020767 18372905 16111806 20593958 7705931 17575224 17389618 17047489 15172127 24836286 16963246 20878130 12637750 16879199 15706408 20346928 18676755 10853026 16331619 21081473 17949449 10072428 10965019 17656264 27222248 23431386 25280562 15954165 18435490 15289873 23202126 21930798 22294766 18949393 12837940 18267032 18829568 18413743 16144935 18483336 11375891 21892161 20565773 25701956 20427397 21369707 18507500 19671906 10485483 18716850 17934461 23548910 18998757 15814641 15753380 ABCA6 ABCB1 ABCB10 ABCB11 ABCC1 ABCC2 ABCC4 ABCC5 ABCG1 ABCG2 AKT1 ARNT BCL2 BIRC5 BMP4 BRAF BUB1B CALR CCND1 CDH1 CDH5 CFTR COL7A1 CSF2 CTNNB1 CYP1A2 CYP1B1 DCLK1 DHFR EFEMP1 EGFR EIF3H ERCC2 ESR2 EVL EXO1 FADS1 FADS2 FAT1 FBLN2 FBN2 FEN1 FGFR3 FLCN FLNC FOXL2 FPGS GATA4 GNB4 GPNMB GSTM1 GSTM3 IGF2 IGFBP3 JPH3 KDR KRAS MDR1 MKI67 MMP1 MMP2 MSH2 NAMPT NME1 NME2 NQO1 OCA ODC1 POLD1 POLE POSTN PPP1R14A PRKCB PRKCE PROM1 PTGS2 PTPRD PTPRJ RET RRM2 SCG5 SELENBP1 SERPINB5 SFRP1 SFRP2 SLC19A1 SMAD4 SMAD7 SOD2 SOX17 SYNE1 TCF7L2 TCN2 TFRC TGFB1 TLR2 TNF TP53 TXNRD1 TYMP UMPS VTI1A WIF1
Obesity	73.89	References/Inference Genes References Inference genes 16317704 11328671 9826672 23819014 19103437 10900012 20567778 10092513 11782876 3519326 12032746 24497646 25551525 9502777 17405841 15687340 16325777 15592485 23349936 25222487 18344982 21156398 20882379 24042701 20869355 23956348 11381268 17062801 2777199 25554529 22537059 9202122 23563609 18334666 26655953 19171794 23834033 26186301 10744717 22484627 14617771 20561897 19270708 18375438 18515891 16289378 11089532 22276206 19079261 11528401 27020609 15184668 20122948 23839791 17517446 15494731 24263156 19153526 19913045 17229951 25086370 20667977 17628001 23954404 20141834 20975297 20716455 21786805 22841818 18604207 20956498 8923850 ACACB ACADM ACP5 ADIPOQ ADRB1 ADRB2 ADRB3 AHR AKT1 ALDH1L1 APOE AQP7 AS1 CA3 COX7C CRP CS CTSS CYB5A CYCS CYP26B1 ECHS1 ENPP1 ESR1 ETFDH F2 FAAH FOXO3 GLUL GNPDA2 GPX1 HADH HK2 HMOX1 HOXB5 HSD11B1 HSPA5 IDO1 IGF2 IGFBP2 IL6 INS KCTD15 LBP LDLR LEP LEPR LPL ME1 MMP9 MTCH2 MUT NAMPT NPY1R NQO1 NR0B2 NR1I2 NR1I3 NTRK2 PACS1 PARP1 PCK1 PCSK1 PFKFB3 POMC PPARA PPARGC1B PRKAR2B PRKCH PTGS2 PTPN1 SAT1 SDC3 SERPINE1 SH2B1 SIRT3 SLC22A1 SOD1 SOD2 SREBF1 STS SUCLG2 TF TFRC TNF TNFRSF1B UCP1 UCP2 UCP3 VLDLR
Myocardial Ischemia	71.62	References/Inference Genes References Inference genes 16155579 11707688 14503966 11840375 10908253 15746188 12447174 14583313 16306806 16214533 16286589 15347709 9860779 12354446 10462014 12173832 16775501 9554809 ACTB ADIPOQ ADRB1 ADRB2 AGT ALDOA BHLHE40 CALR CCL2 CCND1 CCND2 CD36 CD38 CDH2 CPT1B CRP CTSC CXCL2 DCN DLAT DUSP1 EDN1 FABP5 FGF2 GBP2 GCH1 GHR GSTA1 GSTP1 HGF HIVEP2 HK1 HK2 HMGB1 HMGCS2 HMOX1 HSPA1A HSPA9 ID3 IFNGR1 IGF1 IGFBP3 IL1A IL1B IL6 KDR KITLG KLF4 MAP3K8 MEOX2 MX1 NCL NEDD4 NFKBIA NOS3 NR4A1 PDHA1 PEBP1 PFKFB3 PFKM PGM1 POMC PPM1B PPP3R1 PRKCE RXRG SLC6A6 SLC8A1 SOCS3 SOD2 STAT5A SULT1A1 TFRC TMED2 TMPO TNF TXNRD1 VCAM1 VEGFA ZEB1
Autism	66.28	References/Inference Genes References Inference genes 17626784 15471876 19265751 19365831 18621663 11496368 15830322 18759867 9804340 19195803 18929414 16027737 11317216 16946189 20375269 17376794 17203304 11814262 19360663 20071347 16139734 15892143 11354825 11706102 15992526 21359227 20157312 17383819 18563708 20531469 25961944 17883863 18067135 12579522 20663923 19167832 19211884 15363659 18207134 20662941 18492799 15694999 17547689 17280648 11803234 15205966 17597297 19221690 22490277 15046869 20649385 17347881 16027742 18435417 18676531 25217958 17380209 15056512 15288368 17404132 17264841 18179894 17322880 15446388 15820235 14659996 17290275 20468076 8964908 21310003 8098541 18057082 12032595 18270976 15108192 16520824 16297937 15523497 9152989 16721604 18579107 27082637 17033973 14755447 18053270 18348195 16360218 16917939 17292328 21328570 17199132 20452682 20442744 8570775 16472391 16724005 17893705 21082655 ABAT ACADSB ACE ADA ADM ADRB2 ADSL ASIC2 AVPR1A BCL2 C4B CADPS2 CAT CENTG2 CHRNA4 CHRNB2 CNTN3 CNTNAP2 COMT CP CYP19A1 DHCR7 DHFR DLGAP2 EGF EXT1 FOXP2 GHR GJA1 GPX1 GSTM1 GSTP1 HDLBP HRAS HTR5A IFNG IGF1 IGF2 IGFBP3 IL10 IL15 IL1RN IL2 IL4 IL5 IL6 ITGB3 KCNMA1 LAMB1 LASP1 LBA LEP MAOB MARK1 MIF MTF1 NOS2 NRXN1 NTRK2 OXTR PER1 PITX1 PLAUR POMC PON1 PRKCB PRL PRLR PTEN PTGS2 REEP3 RELN RIMS1 RNF8 ROBO1 ROBO4 RORA SCAMP5 SCN7A SERPINE1 SLC19A1 SLC1A3 SLC25A12 SLC40A1 SLC6A4 SNTG2 ST8SIA2 STXBP6 SYNGAP1 TAF1C TCN2 TDO2 TF TNFRSF1B TSC1 VLDLR XDH XPC ZMYND11
Rheumatoid arthritis	64.07	References/Inference Genes References Inference genes 16729287 15292528 18617548 18794853 20453842 3874814 19898481 20080907 16055108 16368150 17568789 20008919 19898480 1568518 16597321 2001072 16872482 16385501 11978490 20476861 23897011 8391952 23143596 23333834 17379860 26001728 22446963 19192274 24313545 22450443 22104130 20453841 12833524 12566094 7706905 19193698 ABCB1 ABCC2 ABCC4 ABCC5 ABCG2 ADIPOQ AGER AHR ANXA3 ARID5B ATIC BAIAP2L1 BMP4 BMP6 CALD1 CAT CCL8 CCR6 CD83 CDK6 CP CRP CSF2 CTGF CTSD CXCL2 CXCR4 DDIT4 DDX6 DFNA5 DHFR ENO1 F2 FKBP5 FOXP3 FPGS GART GC GPRC5A HSD11B1 IFNG IGFBP3 IL10 IL18 IL1B IL1RN IL6 IL6R IRAK1 IRF5 ITGA6 MARCKS MIF MMEL1 MMP10 MMP12 MMP2 MPO NFKBIL1 NOXA PADI4 PON1 PRDM1 PTGS2 PTK2 PTPN2 PTPRC PXK RASGRP1 RBPJ RUNX1 SLC11A1 SLC25A12 SOD2 STAT1 STAT4 STS TLR2 TMPO TNF TNFAIP2 TNFRSF11B TYK2 VEGFA
Mesothelioma, Malignant	61.8	References/Inference Genes References Inference genes 23621518 26678224 23056237 23435014 16850164 20617513 22784439 26928227 16697254 26463840 26818092 25162674 11453316 25756049 20682992 27032653 19190155 21543585 ANXA2 APOA1 BCL2 C9 CCL5 CCL7 CDK6 CDKN1A COL12A1 CSF1 CTNNB1 CXCL12 CXCL9 EFEMP1 EGFR EPHX1 FGF9 FN1 FTH1 GSTM1 HEPH HGF IFNG IGF2BP3 IL1A IL4 IL6 KIT MDK MIF MSLN MUC1 NF2 NGF OPG PARP1 PDPN RXRA SDC1 SETD2 SETDB1 SLC22A5 SLC2A1 SMARCA2 SOD2 TF TFDP2 TGFB2 TP53 ULK2 VIM
Esophageal squamous cell carcinoma	59.72	References/Inference Genes References Inference genes 25151357 23644492 11641616 16639733 15756444 21947696 18167182 21969086 18691855 16543248 15375580 21517111 21206495 18197933 ABCC2 ADCYAP1 ANXA1 BUB1B CA2 CALR CAPZA1 CCND1 CDKN1A CFL1 CLIC1 EGFR FAT1 GSTO1 HMGB1 HSPA5 KRT13 KRT14 KRT17 MAD2L1 NFE2L2 NOTCH1 NOTCH2 NOTCH3 PRDX1 PSME2 PTGS2 RB1 SLC39A6 SOD2 TAGLN TNFAIP8 TP53 TPM1 TYMP XRCC1
HIV Infections	56.39	References/Inference Genes References Inference genes 16597321 12878215 17448989 15308739 10202824 17187345 16903978 12646808 ALB APOA1 ARAP3 BAG3 BAX BIRC3 CCL11 CCL2 CCR3 CCT3 CCT5 CDC42 CDKN1A CLIC1 CXCL12 CXCR1 EIF6 HDGF HP HSP90AA1 HSPA9 HSPB1 HSPD1 HSPH1 IFNG IL10