Definition
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
A trace constit. of plant tissues, e.g. seeds of date (Phoenix dactylifera) and pomegranate (Punica granatum)
Description
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Top Gene Interactions
Related Pathways
Estrone Health Effects
General Information
- Metabolism: Hepatic. Half Life: 19 hours
- Uses/Sources: For management of perimenopausal and postmenopausal symptoms.
- Symptoms: Symptoms of overdose include nausea and vomiting. Estrogen related side effects include nausea, breast tenderness, fluid retention and edema, headaches and/or migraines, chloasma and poor contact lens fit. Estrogen hormone deficiency is associated with breakthrough bleeding, hypomenorrhea, irritability, depression and menopausal symptoms. Withdrawal bleeds may occur in females.
- Route of Exposure: 43%
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Estrogen receptor Estrogen receptor beta Androgen receptor Progesterone receptor Nuclear receptor subfamily 1 group I member 2 |
23611293 |