ESTROGENS

Definition

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

Top Gene Interactions

Related Pathways

Estrogens Health Effects

Estrogens Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Prostatic Neoplasms	79.42	References/Inference Genes References Inference genes 16496412 12445681 14666681 21946351 17785557 16934689 19396168 22666205 17199135 15302576 17176215 15046698 23315858 15790600 16220300 12893367 19082440 17542986 25908785 11742035 19011039 12771559 24586243 17606477 17202838 19283074 15672864 17646272 16000583 16434975 17688413 20676098 17003774 17136230 21456062 17132221 16998812 9371490 20052738 26443449 16733517 14975756 17914592 15318950 24500903 16427044 22919386 12429631 12592389 17173048 19074884 20140206 16859836 16266977 17639508 19208208 16541421 11222871 17592021 19081794 17141945 19240160 15598783 16606632 12727815 22581815 25062956 20729295 17919073 15159307 17196171 15389811 20932324 17704407 22610119 16921512 18082198 15042602 16908180 23248098 25735316 15386377 17013881 16465378 16458450 22564066 12610512 20875869 17465268 24763052 17898866 18829485 25970160 17363613 16877366 19593445 15999119 20347977 16424004 16984552 12237244 16421604 21714127 15538743 23704919 11275366 26005866 AHR ALAD AURKA BAD BCL2 BGLAP BMP7 CCND1 CDKN1A CDKN1B COMT CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP2E1 EGFR ERBB2 ESR1 ESR2 FOXP4 GREB1 ID3 IGF1 IGFBP3 IL18 IL6 INS LBA LEP LPL MAPK3 MYC NOS3 NR3C1 OLFM1 PPARA PRSS8 PTEN RXRA SOD2 STAT3 TGFB1 TP53 UMPS VDR VEGFA WNT4
Breast carcinoma	77.94	References/Inference Genes References Inference genes 16950593 19968660 16792888 25221644 19075277 11583189 17255770 16495393 20941507 20458558 19435922 16968874 19548127 19756960 20104649 22174584 16978400 20154726 26229107 20421688 17965603 17520698 12165863 19636701 18086299 11970740 15581045 15375496 23621182 11850205 22302033 16682728 21057462 19617202 20234815 17132221 19436038 12839951 12655533 19801490 15958052 19839049 14975756 19671875 17417639 26124351 25330770 9407957 18492817 21638049 20135347 16091755 18521742 16904380 22267197 16077979 24014025 16234514 10930538 25078270 12517783 11222871 26192916 12006526 19913079 21515334 15802278 18949741 21489049 15631943 11237771 23867902 19639193 19020767 11248153 17614302 17516992 23001124 24185512 18398872 15706428 19151563 21501481 16596621 17297925 26437033 10897039 18066063 16137437 15455371 16298037 20197467 15994142 15970926 25358515 18840765 16954440 21353530 20400965 19896266 16280049 22892281 22296396 19434490 21633166 19238537 24185510 20961995 22531848 17388661 20562527 18819904 17092400 18497064 16446318 22038807 19385967 20948315 17474063 23839043 19652463 21098263 20332317 16865596 19685490 18768436 25267515 23342035 19446661 ABCC1 ABCG2 ABL1 AHR ANGPTL4 AREG AURKA BCL2 CCND1 CDKN1B COMT CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 EFNA1 EGFR ERBB2 ESR1 ESR2 ESRRA FOS FST HRAS IGF1 IGF1R IL1B IL6 JUN LBA LEP MKI67 MMP14 MMP-3 NOS2 NOS3 NRIP1 PGR PTEN RARA SOD2 SPP1 STAT3 STC2 TBX3 TFRC TNF TP53 UMPS VDR ZEB1
Stomach Neoplasms	61.56	References/Inference Genes References Inference genes 21173787 24816253 18593901 12107286 10853026 19584167 25279216 17003101 19140230 16134180 15492468 19806464 21628965 19424620 16912530 15640503 15448013 26558449 17171786 23382965 14503839 17355264 24816255 22042947 15723263 17089033 23593346 16367923 22414649 18652704 22484628 15201584 15940630 1733439 15138205 21532492 11397402 14647439 AHR ALB AREG BDNF BMP7 CCND1 CDH2 CDKN1A CDKN1B EGFR ERBB2 FST HRAS IGFBP3 IL1B IL6 JUN MAPK1 MAPK3 MAPK8 MYC NOS3 PPARG RBP1 RHOA SOD2 STAT3 TBX3 TNF TP53 TWIST1 UMPS
Hepatocellular carcinoma	55.94	References/Inference Genes References Inference genes 16831601 15565109 20214788 12029619 19919837 19731237 18477611 21472284 2821104 9311599 16092956 17191126 8200073 17615358 18230555 19100240 16374840 22649188 22922871 25822088 19363144 27022031 12203361 20698225 17441810 20818158 15341023 18026104 22675488 14563831 26189965 20118494 8033108 12532445 15162526 23958494 18639551 16767786 22561517 18760346 9029167 CCND1 CDKN1B CEBPB COMT CXCL12 CYP17A1 CYP1A1 CYP2E1 EGFR ESR1 F2 FOS FST HRAS IGF1R IGF2 IL6 IRF2 JUN LBA MYC PPARG PTEN RARA RRM2 SLIT2 SOCS3 SOD2 TGFB1 TH TNF TP53 UMPS VCAM1
Adenocarcinoma	55.07	References/Inference Genes References Inference genes 20464547 15639718 20458558 12907644 16142352 11034103 21673877 11798837 20934974 21670700 6280079 21552421 17418594 19028472 21472143 22042947 17909629 22484628 21541241 17639508 26432044 10797276 1733439 2523869 20495387 ABL1 BCL2 CCND1 CYP19A1 CYP2E1 EGFR ERBB2 ESR1 ESR2 FGF9 HOXA10 ID3 IL1B MKI67 MMP14 MYC NOS3 PGR PPARG PRL PTEN SOD2 SPP1 STAT3 TGFB1 TNF TP53 VEGFA
Reperfusion Injury	49.07	References/Inference Genes References Inference genes 7922267 16526316 17032661 23875703 19058328 20302854 19151258 12024109 15449323 19673871 10594344 17112405 16682413 19038262 21968084 24011919 15829914 24433871 19917352 10706834 18258783 12468449 25780291 23075401 10383581 21940958 18460982 23743330 16971220 16968891 8215636 19193722 23061969 AGT BCL2 CASP3 CCL2 CDKN1A CHAT CXCL1 FOS ID3 IL1A IL1B IL6 JUN MAPK8 NOS2 NOS3 PPARA PPARG PTEN SOCS1 SOD2 STAT3 TNF
Diabetes Mellitus, Experimental	45.16	References/Inference Genes References Inference genes 14871415 14563825 12123627 22933112 22342832 22138235 11696579 20654064 16123366 16959961 18829990 24513509 23792339 21757225 15490108 12967931 23090186 20388520 17177138 18266981 24632065 11947963 12193562 16380483 19478208 12198386 15831366 22191573 15855331 AGT BCL2 CASP3 CYP1A1 ESRRA IGF1 IL1B IL6 NOS2 NOS3 PPARA PPARG PRKCD REN SLC2A4 SOD2 TGFB1 TNF TP53 VEGFA
Hypertension	45.01	References/Inference Genes References Inference genes 22228705 12860835 2526952 20634294 18785976 19834340 22995157 20667508 10075388 7323490 1394429 14751847 3158602 11457755 17023265 15513305 18420994 45830 22452651 16331104 18434569 12084390 1149188 15851630 20811386 25259750 16864745 15243307 21115475 998518 2835134 12600921 24965170 1875449 21420289 15646324 10400907 62162 16827954 23973649 11682445 16868307 27292124 20123609 8505092 10523385 21393355 11459117 23348737 18847324 17272743 19770776 1860718 6381767 1849535 25874449 19344079 19018797 9260993 22214961 20429690 21593737 16054168 9024144 10818254 18605955 22753205 1071603 18679781 27226618 12044476 26564064 18360027 10526905 25139994 20231528 15174897 12414515 6742791 8021468 7721401 24039778 12050272 15699457 24935938 21501650 15302986 1432030 11752024 12121858 17537837 21289285 19666838 43064 16618834 19858406 20713914 18768397 12947532 19008412 19407804 8109997 16788141 2831029 24347665 11501062 24342267 15199296 9719048 15198480 19133994 20837116 19502719 20937366 2059916 15833808 17989111 11834524 22982863 25205467 12676074 11335187 19109942 19373235 20659135 25101153 ABCC1 ADIPOQ AGT AHR ALAD ALB AQP1 BCL2 CCL2 CYP1A1 EDN3 FOS GAL IGF1 IL1B IL6 INS JUN LBA LEP LPL NOS2 NOS3 NR3C1 PPARA PPARG PRKCD PTEN REN SCNN1A SCNN1B SCNN1G SELP SOD2 SOD3 TGFB1 TNF TP53 VCAM1 VDR
Carcinoma	44.62	References/Inference Genes References Inference genes 21489049 22180778 12376462 9626339 9326929 8185828 16316942 12417722 17173897 11053990 17450239 24816255 11137312 10853026 2228319 14522882 15637090 10426811 15302576 ACKR3 ANGPTL4 AQP1 BCL2 CCND1 EGFR ESR1 ESR2 FABP4 HRAS ID3 LPL MYC PGR PPARA PTEN RBP1 RHOA SOD2 SOX9 STAT3 TGFB1 TP53 TSC22D1
Mammary Neoplasms, Experimental	44.37	References/Inference Genes References Inference genes 15528971 12376462 25221644 15217511 22767648 21283680 8185828 16316942 17584969 11137312 8603490 14522882 11376698 2523869 12124350 15318939 15637090 23964924 ABCG2 AQP1 AURKA CCND1 EGFR ERBB2 ESR1 ESR2 FABP4 HRAS ID3 IGF1 LPL PGR PPARA PRL RBP1 SOD2 SOX9 SPP1 STAT3 TFF1 TSC22D1
Colorectal cancer	44.16	References/Inference Genes References Inference genes 24836286 21946351 23431386 12907644 12637750 18507500 21278247 19020767 10853026 12645814 22294766 21544799 20878130 16110022 21081473 15731169 15814641 17949449 18949393 16489531 16111806 18998757 24976383 22180778 16524972 15954165 15172127 18676755 17575224 ABCC1 ABCC5 ABCG1 ABCG2 ACKR3 AURKA BCL2 CCND1 CFTR CYP1A2 CYP1B1 EGFR ESR2 IGF2 IGFBP3 MKI67 POSTN PPARG RET RRM2 SOD2 TFRC TGFB1 TNF TP53 UMPS
Colonic neoplasm	42.47	References/Inference Genes References Inference genes 16105666 17354198 17510416 12189186 10223192 18283038 17192441 25279216 17404573 18987561 21081470 15057734 15059925 19147571 20540935 19028472 12628520 20876807 18652704 14569062 17075118 21188121 25200834 11222871 26192916 12842827 ATP7A BCL2 CCND1 CDKN1A EGFR ERBB2 ID3 IGF2 IL1B JUN LEP LPL MKI67 MYC NOS2 PPARG SOD2 STAT3 TNF TP53 UMPS VEGFA
Liver Cirrhosis, Experimental	42.13	References/Inference Genes References Inference genes 14724832 26806094 17963606 18458672 16642209 15591519 17127702 16097051 21163135 18416461 16579972 16085334 18380797 15745444 15492853 25380136 12667390 17072980 18555214 15772939 15197228 12586293 ABCC5 ABCG1 ACKR3 ADIPOQ AGT ALB ANGPTL3 BMP7 CCL2 CDKN1A COL1A2 CXCL1 CXCL12 CYP17A1 CYP1A2 FOS GOT1 HCK IGF1 IGFBP3 IL18 IL1B INS INSIG2 LEP LPL MKI67 MYC NOS2 NOS3 PRKCD RAB31 SOCS1 TGFB1 TGFB3 TNF TSC22D1 VEGFA
Neoplasm Metastasis	38.71	References/Inference Genes References Inference genes 18930813 23867902 23431386 21937440 20158913 19806464 20104649 18398872 22407340 17369752 21948867 21312072 12748951 8032535 15659795 23382965 17949449 10978354 23992306 16984552 17130448 21996746 22580338 22180778 23876460 23743303 21986133 23146760 12538496 22321834 26896736 17575224 19487542 ACKR3 AHR ANGPTL4 CDH2 CXCL12 EGFR ERBB2 ESR1 GAB2 IGF1 IL18 IL6 MAPK1 MAPK3 MYC PIK3C2B PTEN SOD2 SPP1 STAT3 TGFB1 TNF TP53 TWIST1 VEGFA
Brain Ischemia	38.59	References/Inference Genes References Inference genes 16809570 17901229 19922383 15737438 17394460 9236716 15756928 11756504 15829914 9778187 19429140 14753426 15060315 19095966 15534175 ALB BDNF CASP3 CCL2 CEBPB CYCS F2 IL18 IL1A IL1B IL6 JUN MAPK1 MAPK3 NOS2 SOD2 STAT3 TNF TP53
Lung Neoplasms	37.98	References/Inference Genes References Inference genes 20464547 15902970 1673675 11552296 22072123 16391232 11798837 12083368 18927287 20512841 18508827 12466968 20716630 12376484 12460898 20934974 11074608 22481206 11307925 16289808 16904380 17093202 21552421 17418594 23523951 22369883 17909629 19336973 11872642 17325666 12483526 21541241 20727180 14587096 10779650 17077188 26372664 26192916 11376689 16410370 11884234 12765245 11641043 CCND1 CDKN1A CDKN1B CYP1A2 CYP1B1 CYP2E1 EGFR ERBB2 ESR1 FGF9 FOS HRAS ID3 IL1B IL6 JUN MAPK1 MAPK3 MYC NOS2 PTEN SPP1 TFRC TGFB1 TNF TP53
Mammary Neoplasms, Animal	36.8	References/Inference Genes References Inference genes 12376462 6280079 8185828 16316942 17173897 11137312 18424824 8603490 14522882 15637090 AQP1 CCND1 COMT EGFR ERBB2 ESR1 ESR2 FABP4 HRAS ID3 LPL PGR PPARA PRL RBP1 SOX9 STAT3 TSC22D1
Neoplasm Invasiveness	35.2	References/Inference Genes References Inference genes 23431386 23867902 24793912 15048980 19700239 10853026 26284488 23877152 25753200 26213588 25884904 22199285 20188714 25199511 18398872 25826687 18844224 15654357 24727557 22155737 21994956 23992306 23899529 24014025 19896475 11053990 17130448 21749277 21954225 21996746 22580338 25231984 24951586 24613819 26896736 19799886 AHR ANGPTL4 CCL2 CXCL12 CYP2E1 EGFR EPS8 GAB2 HRAS IGF1 IL6 MAPK1 MAPK3 MMP14 MMP-3 PTEN RHOA SMPD1 SOD2 TGFB1 TNF TWIST1 ZEB1
Myocardial Ischemia	32.31	References/Inference Genes References Inference genes 9860779 16775501 12354446 14583313 16214533 16155579 15347709 14503966 16286589 ADIPOQ AGT AREG CCL2 CCND1 CDH2 ID3 IGF1 IGFBP3 IL1A IL1B IL6 NOS3 SELP SOCS3 SOD2 TFRC TNF VCAM1 VEGFA ZEB1
Infertility, Female	31.71	References/Inference Genes References Inference genes 21177758 14684609 22532853 18645707 19531635 8220432 22265003 23710174 CEBPB CYP17A1 CYP19A1 ESR1 ESR2 FSHB LBA LEP MAPK1 MAPK3 PRL TP53

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Estrogens Health Effects

Estrogens Interacts with Diseases

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Estrogens

Definition

Top Gene Interactions

Related Pathways

Estrogens Health Effects

Estrogens Interacts with Diseases

Estrogens Interacts with Genes

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