ESTROGENS

Definition

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

Top Gene Interactions

Related Pathways

Estrogens Health Effects

Estrogens Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Prostatic Neoplasms	79.42	References/Inference Genes References Inference genes 17704407 16434975 24763052 12727815 19283074 17592021 17202838 16541421 25908785 15672864 19081794 12592389 19593445 12237244 12610512 17363613 17199135 16877366 15598783 20052738 20676098 26005866 21714127 24500903 12445681 19074884 16465378 24586243 25970160 17898866 22564066 15790600 16220300 17606477 17914592 14975756 22581815 17785557 17646272 15046698 20140206 16934689 16859836 16606632 16427044 15389811 18082198 15159307 25735316 17542986 19240160 16921512 23248098 25062956 23704919 19011039 16424004 16733517 17136230 16458450 17173048 15042602 17132221 16266977 17919073 15302576 12771559 20347977 17013881 11742035 19208208 17003774 16000583 15999119 23315858 20932324 16421604 17176215 26443449 21456062 11275366 11222871 17196171 22610119 16998812 17465268 15386377 16908180 16984552 22919386 21946351 18829485 20875869 17141945 19396168 16496412 22666205 14666681 20729295 12429631 17688413 15538743 19082440 9371490 17639508 12893367 15318950 AHR ALAD AURKA BAD BCL2 BGLAP BMP7 CCND1 CDKN1A CDKN1B COMT CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP2E1 EGFR ERBB2 ESR1 ESR2 FOXP4 GREB1 ID3 IGF1 IGFBP3 IL18 IL6 INS LBA LEP LPL MAPK3 MYC NOS3 NR3C1 OLFM1 PPARA PRSS8 PTEN RXRA SOD2 STAT3 TGFB1 TP53 UMPS VDR VEGFA WNT4
Breast carcinoma	77.94	References/Inference Genes References Inference genes 19636701 15970926 25358515 22892281 21489049 19020767 16077979 19446661 22267197 22038807 23867902 17297925 16954440 16298037 16137437 19639193 19913079 15581045 19671875 22302033 16978400 20154726 19617202 23621182 17092400 22174584 9407957 16865596 18840765 17516992 15375496 17417639 11850205 18398872 17255770 23839043 20332317 26124351 18768436 20948315 18497064 16280049 19968660 15631943 20234815 25330770 11248153 12839951 19151563 12517783 23001124 21057462 20104649 16792888 17965603 17388661 14975756 19685490 20961995 16682728 18086299 16446318 19839049 18521742 12006526 22296396 15706428 11583189 17520698 15455371 26437033 18949741 25221644 18066063 24185512 20197467 17614302 25078270 16091755 21515334 25267515 21353530 19652463 17132221 26229107 20421688 19075277 16950593 21501481 15994142 19548127 22531848 19238537 19434490 11970740 19435922 19801490 20562527 17474063 12165863 18819904 19756960 21633166 11222871 11237771 24185510 20400965 21098263 16495393 19436038 16968874 19896266 26192916 16234514 10930538 10897039 15802278 15958052 23342035 20941507 21638049 24014025 16904380 12655533 18492817 20458558 19385967 20135347 16596621 ABCC1 ABCG2 ABL1 AHR ANGPTL4 AREG AURKA BCL2 CCND1 CDKN1B COMT CXCL12 CYP17A1 CYP19A1 CYP1A1 CYP1B1 EFNA1 EGFR ERBB2 ESR1 ESR2 ESRRA FOS FST HRAS IGF1 IGF1R IL1B IL6 JUN LBA LEP MKI67 MMP14 MMP-3 NOS2 NOS3 NRIP1 PGR PTEN RARA SOD2 SPP1 STAT3 STC2 TBX3 TFRC TNF TP53 UMPS VDR ZEB1
Stomach Neoplasms	61.56	References/Inference Genes References Inference genes 15201584 19424620 18652704 19584167 17355264 22414649 18593901 21628965 19806464 15492468 14503839 15448013 26558449 17171786 15138205 15940630 24816253 10853026 23382965 19140230 15723263 16912530 17089033 1733439 12107286 15640503 14647439 16134180 16367923 11397402 21173787 24816255 22042947 23593346 22484628 25279216 17003101 21532492 AHR ALB AREG BDNF BMP7 CCND1 CDH2 CDKN1A CDKN1B EGFR ERBB2 FST HRAS IGFBP3 IL1B IL6 JUN MAPK1 MAPK3 MAPK8 MYC NOS3 PPARG RBP1 RHOA SOD2 STAT3 TBX3 TNF TP53 TWIST1 UMPS
Hepatocellular carcinoma	55.94	References/Inference Genes References Inference genes 20214788 19363144 20698225 15162526 16374840 19100240 18760346 21472284 20118494 8033108 19919837 20818158 18026104 19731237 15341023 17191126 12203361 9311599 16092956 2821104 16767786 25822088 9029167 22675488 8200073 18639551 17615358 15565109 22649188 27022031 17441810 12029619 14563831 12532445 23958494 22561517 22922871 26189965 18477611 18230555 16831601 CCND1 CDKN1B CEBPB COMT CXCL12 CYP17A1 CYP1A1 CYP2E1 EGFR ESR1 F2 FOS FST HRAS IGF1R IGF2 IL6 IRF2 JUN LBA MYC PPARG PTEN RARA RRM2 SLIT2 SOCS3 SOD2 TGFB1 TH TNF TP53 UMPS VCAM1
Adenocarcinoma	55.07	References/Inference Genes References Inference genes 21472143 10797276 11798837 17418594 11034103 16142352 2523869 20464547 19028472 15639718 21670700 12907644 20495387 21541241 21673877 21552421 26432044 17909629 1733439 6280079 22042947 22484628 20458558 17639508 20934974 ABL1 BCL2 CCND1 CYP19A1 CYP2E1 EGFR ERBB2 ESR1 ESR2 FGF9 HOXA10 ID3 IL1B MKI67 MMP14 MYC NOS3 PGR PPARG PRL PTEN SOD2 SPP1 STAT3 TGFB1 TNF TP53 VEGFA
Reperfusion Injury	49.07	References/Inference Genes References Inference genes 10706834 16526316 17112405 16682413 10383581 23075401 21940958 12024109 19151258 23743330 18460982 23875703 16968891 18258783 21968084 16971220 25780291 8215636 19038262 10594344 23061969 19673871 19193722 19917352 15829914 15449323 17032661 12468449 7922267 24011919 19058328 20302854 24433871 AGT BCL2 CASP3 CCL2 CDKN1A CHAT CXCL1 FOS ID3 IL1A IL1B IL6 JUN MAPK8 NOS2 NOS3 PPARA PPARG PTEN SOCS1 SOD2 STAT3 TNF
Diabetes Mellitus, Experimental	45.16	References/Inference Genes References Inference genes 18829990 15831366 12123627 12198386 22138235 20388520 14563825 16123366 24632065 18266981 23090186 11696579 15490108 19478208 17177138 22191573 23792339 16380483 16959961 14871415 24513509 11947963 22933112 20654064 15855331 21757225 12967931 22342832 12193562 AGT BCL2 CASP3 CYP1A1 ESRRA IGF1 IL1B IL6 NOS2 NOS3 PPARA PPARG PRKCD REN SLC2A4 SOD2 TGFB1 TNF TP53 VEGFA
Hypertension	45.01	References/Inference Genes References Inference genes 21393355 19858406 19018797 9260993 27292124 1860718 23973649 20937366 19502719 18360027 8021468 10526905 12414515 7721401 20429690 18785976 9719048 27226618 19407804 22452651 8505092 10818254 21593737 2835134 25874449 11834524 25139994 17989111 12860835 20659135 10523385 6742791 1849535 15646324 12044476 15199296 45830 19770776 22214961 25101153 18434569 18679781 21420289 21501650 998518 17272743 26564064 24342267 16054168 15302986 19834340 11501062 18768397 1149188 20837116 15851630 24039778 16618834 16788141 24965170 20231528 18605955 16868307 20634294 10400907 21289285 24935938 19373235 25259750 2059916 9024144 11459117 20667508 11752024 12121858 20713914 62162 12947532 22753205 16827954 1394429 43064 2831029 11682445 11457755 21115475 22982863 3158602 25205467 15699457 12084390 22995157 15243307 18420994 20811386 17023265 15513305 15174897 7323490 23348737 6381767 19133994 18847324 8109997 19109942 10075388 1432030 16864745 17537837 12676074 11335187 14751847 19344079 1875449 19008412 15833808 2526952 16331104 12600921 15198480 20123609 1071603 12050272 22228705 19666838 24347665 ABCC1 ADIPOQ AGT AHR ALAD ALB AQP1 BCL2 CCL2 CYP1A1 EDN3 FOS GAL IGF1 IL1B IL6 INS JUN LBA LEP LPL NOS2 NOS3 NR3C1 PPARA PPARG PRKCD PTEN REN SCNN1A SCNN1B SCNN1G SELP SOD2 SOD3 TGFB1 TNF TP53 VCAM1 VDR
Carcinoma	44.62	References/Inference Genes References Inference genes 11053990 8185828 22180778 9326929 10853026 10426811 17450239 24816255 11137312 21489049 16316942 15637090 12417722 14522882 9626339 12376462 17173897 15302576 2228319 ACKR3 ANGPTL4 AQP1 BCL2 CCND1 EGFR ESR1 ESR2 FABP4 HRAS ID3 LPL MYC PGR PPARA PTEN RBP1 RHOA SOD2 SOX9 STAT3 TGFB1 TP53 TSC22D1
Mammary Neoplasms, Experimental	44.37	References/Inference Genes References Inference genes 8185828 8603490 15528971 12124350 11137312 15318939 16316942 2523869 15637090 22767648 11376698 25221644 14522882 17584969 12376462 15217511 23964924 21283680 ABCG2 AQP1 AURKA CCND1 EGFR ERBB2 ESR1 ESR2 FABP4 HRAS ID3 IGF1 LPL PGR PPARA PRL RBP1 SOD2 SOX9 SPP1 STAT3 TFF1 TSC22D1
Colorectal cancer	44.16	References/Inference Genes References Inference genes 12637750 22294766 21278247 15814641 19020767 15172127 18949393 15954165 12907644 12645814 18507500 16110022 18998757 16489531 10853026 15731169 21544799 21946351 16524972 17575224 16111806 23431386 17949449 20878130 24976383 24836286 22180778 18676755 21081473 ABCC1 ABCC5 ABCG1 ABCG2 ACKR3 AURKA BCL2 CCND1 CFTR CYP1A2 CYP1B1 EGFR ESR2 IGF2 IGFBP3 MKI67 POSTN PPARG RET RRM2 SOD2 TFRC TGFB1 TNF TP53 UMPS
Colonic neoplasm	42.47	References/Inference Genes References Inference genes 15057734 18652704 12189186 18283038 15059925 17192441 11222871 19028472 18987561 26192916 21188121 17404573 17075118 14569062 10223192 21081470 20876807 16105666 25200834 20540935 19147571 12628520 12842827 17354198 25279216 17510416 ATP7A BCL2 CCND1 CDKN1A EGFR ERBB2 ID3 IGF2 IL1B JUN LEP LPL MKI67 MYC NOS2 PPARG SOD2 STAT3 TNF TP53 UMPS VEGFA
Liver Cirrhosis, Experimental	42.13	References/Inference Genes References Inference genes 18458672 12667390 15492853 15591519 17127702 26806094 15745444 17963606 16097051 21163135 14724832 15197228 17072980 18380797 16085334 12586293 15772939 18416461 18555214 16642209 25380136 16579972 ABCC5 ABCG1 ACKR3 ADIPOQ AGT ALB ANGPTL3 BMP7 CCL2 CDKN1A COL1A2 CXCL1 CXCL12 CYP17A1 CYP1A2 FOS GOT1 HCK IGF1 IGFBP3 IL18 IL1B INS INSIG2 LEP LPL MKI67 MYC NOS2 NOS3 PRKCD RAB31 SOCS1 TGFB1 TGFB3 TNF TSC22D1 VEGFA
Neoplasm Metastasis	38.71	References/Inference Genes References Inference genes 21312072 17130448 12538496 10978354 18398872 17369752 19806464 23876460 18930813 23867902 21996746 21948867 16984552 22321834 23382965 17575224 20104649 23431386 26896736 17949449 15659795 22180778 19487542 22580338 23743303 20158913 8032535 12748951 22407340 21986133 23146760 23992306 21937440 ACKR3 AHR ANGPTL4 CDH2 CXCL12 EGFR ERBB2 ESR1 GAB2 IGF1 IL18 IL6 MAPK1 MAPK3 MYC PIK3C2B PTEN SOD2 SPP1 STAT3 TGFB1 TNF TP53 TWIST1 VEGFA
Brain Ischemia	38.59	References/Inference Genes References Inference genes 11756504 9236716 14753426 15534175 15737438 15060315 19429140 19922383 15756928 15829914 16809570 19095966 17394460 17901229 9778187 ALB BDNF CASP3 CCL2 CEBPB CYCS F2 IL18 IL1A IL1B IL6 JUN MAPK1 MAPK3 NOS2 SOD2 STAT3 TNF TP53
Lung Neoplasms	37.98	References/Inference Genes References Inference genes 16391232 11798837 17418594 18508827 1673675 20512841 17093202 20727180 10779650 20464547 19336973 14587096 12765245 22072123 22369883 26192916 20716630 11376689 11641043 11884234 12083368 11074608 17077188 12376484 21541241 18927287 11872642 21552421 26372664 11307925 15902970 17325666 17909629 11552296 16904380 12466968 23523951 16289808 12483526 16410370 12460898 22481206 20934974 CCND1 CDKN1A CDKN1B CYP1A2 CYP1B1 CYP2E1 EGFR ERBB2 ESR1 FGF9 FOS HRAS ID3 IL1B IL6 JUN MAPK1 MAPK3 MYC NOS2 PTEN SPP1 TFRC TGFB1 TNF TP53
Mammary Neoplasms, Animal	36.8	References/Inference Genes References Inference genes 8185828 8603490 11137312 16316942 15637090 18424824 14522882 12376462 17173897 6280079 AQP1 CCND1 COMT EGFR ERBB2 ESR1 ESR2 FABP4 HRAS ID3 LPL PGR PPARA PRL RBP1 SOX9 STAT3 TSC22D1
Neoplasm Invasiveness	35.2	References/Inference Genes References Inference genes 17130448 21994956 22199285 20188714 25199511 19799886 18398872 23877152 24613819 26213588 25826687 21749277 24727557 22155737 15654357 23899529 23867902 21996746 24793912 10853026 19896475 19700239 23431386 25753200 26896736 21954225 25884904 26284488 11053990 24014025 22580338 25231984 24951586 15048980 18844224 23992306 AHR ANGPTL4 CCL2 CXCL12 CYP2E1 EGFR EPS8 GAB2 HRAS IGF1 IL6 MAPK1 MAPK3 MMP14 MMP-3 PTEN RHOA SMPD1 SOD2 TGFB1 TNF TWIST1 ZEB1
Myocardial Ischemia	32.31	References/Inference Genes References Inference genes 12354446 9860779 14583313 15347709 16286589 16155579 16214533 14503966 16775501 ADIPOQ AGT AREG CCL2 CCND1 CDH2 ID3 IGF1 IGFBP3 IL1A IL1B IL6 NOS3 SELP SOCS3 SOD2 TFRC TNF VCAM1 VEGFA ZEB1
Infertility, Female	31.71	References/Inference Genes References Inference genes 23710174 18645707 19531635 21177758 22265003 14684609 8220432 22532853 CEBPB CYP17A1 CYP19A1 ESR1 ESR2 FSHB LBA LEP MAPK1 MAPK3 PRL TP53

Definition

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Estrogens Health Effects

Estrogens Interacts with Diseases

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Estrogens

Definition

Top Gene Interactions

Related Pathways

Estrogens Health Effects

Estrogens Interacts with Diseases

Estrogens Interacts with Genes

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