ESTRIOL

Definition

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Estriol (also oestriol) is one of the three main estrogens produced by the human body. (Wikipedia)

Description

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.

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Estriol Health Effects

General Information

Uses/Sources: Used as a test to determine the general health of an unborn fetus.

Toxicity

Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
Toxicity: ORAL (LD50): Acute: >2000 mg/kg [Rat].

Mechanism of Action

Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Target Name	Mechanism of Action	References
Estrogen receptor Estrogen receptor beta Androgen receptor Progesterone receptor		23611293

Estriol Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Breast carcinoma	47.3	References/Inference Genes References Inference genes 17520698 19435922 17516992 22892281 15375496 20154269 17417639 11850205 21633166 18398872 24185512 24185510 22311042 25151356 15609129 19436038 19446661 22038807 16280049 15631943 23624423 10930538 25330770 16298037 18497072 23342035 17132221 23001124 19639193 20421688 20104649 16792888 25751625 19671875 21501481 24014025 19548127 20354179 20458558 19385967 19434490 22174584 ABCB1 ABCG2 AFP CCNE1 CYP19A1 CYP1A1 EIF2S2 ESR1 ESR2 FOS IFNG IGF1 IGFBP5 IL6 JUN LBA NOS2 NOS3 PDZK1 PGR RELA STAT5A TNF VDR
Prostatic Neoplasms	42.88	References/Inference Genes References Inference genes 15389811 17176215 15159307 18082198 25735316 17704407 26443449 19240160 12445681 11275366 16921512 25062956 17196171 23704919 24763052 19011039 12727815 16424004 22610119 16284379 16458450 16998812 17173048 16908180 16465378 17999153 25908785 18174250 15672864 24586243 25970160 17132221 15790600 12237244 16220300 23936228 18829485 16266977 17919073 16552752 17141945 22666205 20347977 20729295 15046698 16934689 12429631 17013881 19208208 11742035 16877366 16859836 15598783 17003774 17220347 16606632 20052738 17639508 12893367 CDKN1A CTSD CYP19A1 CYP1A1 EGR1 ESR1 ESR2 IGF1 IL10 IL6 LBA MAPK3 MYC NOS3 PDZK1 SHBG SLC12A2 TGFB1 UGT2B15 VDR VEGFA
Liver Cirrhosis, Experimental	39.63	References/Inference Genes References Inference genes 18458672 15591519 26806094 16126171 15745444 17963606 16953842 21163135 16539848 18251166 15996030 17072980 16688825 18380797 15362042 16097045 12632514 16085334 12586293 16609999 15772939 18416461 16552806 18555214 17347453 12389079 16642209 25380136 16579972 ABCB1 AFP ALB BMF CCNB2 CD276 CD86 CDKN1A FOS FOXA2 IFNG IGF1 IL10 MYC NOS2 NOS3 RELA TGFB1 TNF VEGFA
Hepatocellular carcinoma	37.04	References/Inference Genes References Inference genes 20214788 21472284 12029619 15276417 19363144 24012840 20818158 9029167 22634754 17510421 22922871 18639551 17615358 16217749 15341023 15565109 16831601 27022031 ABCB1 AFP CCNE1 CD276 CTSD CYP1A1 ESR1 FOS IL6 JUN LBA MYC SOCS3 TGFB1 TNF VCAM1
Reperfusion Injury	32.69	References/Inference Genes References Inference genes 10706834 16526316 10383581 17112405 23075401 21940958 23743330 18460982 23875703 16968891 18258783 21968084 16971220 23061969 19673871 15829914 17032661 12468449 7922267 19058328 20302854 12024109 CDKN1A EGR1 FOS IL10 IL12A IL1A IL6 JUN NOS2 NOS3 RELA TNF
Adenocarcinoma	31.97	References/Inference Genes References Inference genes 21552421 26432044 21472143 15639718 15378696 21670700 19028472 17418594 14991897 1733439 20458558 17639508 20235097 6280079 CKB CYP19A1 ESR1 ESR2 HOXA10 MYC NOS3 PGR PRL SELENBP1 STAT5A TGFB1 TNF VEGFA
Mammary Neoplasms, Experimental	28.87	References/Inference Genes References Inference genes 16322315 14999141 15609129 15528971 17584969 16316942 15637090 22767648 12376462 15217511 21283680 ABCG2 AFP ESR1 ESR2 IGF1 IL10 PGR PRL SLC12A2 STAT5A TFF1
Hernia, Diaphragmatic	28.24	References/Inference Genes References Inference genes 10541330 12759764 11685700 16863852 7576705 18500730 10370016 8863223 10646786 FOXA2 IGF1 IL6 NOS3 TGFB1 THRA TNF VCAM1
Brain Ischemia	27.93	References/Inference Genes References Inference genes 18628779 15756928 16809570 15829914 17394460 17901229 9778187 ALB EGR1 IL1A IL6 JUN MAPK1 MAPK3 NOS2 RELA TNF
Lung Neoplasms	27.61	References/Inference Genes References Inference genes 21552421 14587096 7614408 11872642 17418594 22369883 26372664 16289808 14991897 12466968 20716630 11641043 18508827 12460898 11884234 11074608 12083368 17077188 12376484 CDKN1A ESR1 FOS IFNG IL10 IL6 JUN MAPK1 MAPK3 MYC NOS2 SELENBP1 STAT5A TGFB1 TNF
Heat Stroke	27.1	References/Inference Genes References Inference genes 24039931 16878031 FOS IL10 IL1A IL6 JUN RELA TNF
Rheumatoid arthritis	27.07	References/Inference Genes References Inference genes 2001072 22450443 16385501 12566094 20080907 23897011 19192274 12833524 16368150 8391952 22104130 ABCB1 ABCG2 AGER CTSD IFNG IL10 IL23A IL6 TNF VEGFA
Stomach Neoplasms	26.85	References/Inference Genes References Inference genes 15993841 15201584 15378696 21173787 1733439 23382965 19424620 23593346 17355264 17003101 17171786 14647439 16367923 ACTC1 AFP ALB AURKB CDKN1A CKB IL6 JUN MAPK1 MAPK3 MYC NOS3 SELENBP1 TNF
Neoplasm Metastasis	25.99	References/Inference Genes References Inference genes 15659795 22321834 22580338 20158913 20104649 18930813 23431386 8032535 18059164 12015757 23146760 26896736 18398872 23992306 21937440 ABCB1 AGTR1 ESR1 IGF1 IL6 MAPK1 MAPK3 MYC TGFB1 TNF VEGFA
Diabetes Mellitus, Experimental	25.56	References/Inference Genes References Inference genes 12193562 19478208 17177138 24513509 12123627 22191573 22933112 11696579 16380483 18266981 21340626 22342832 22138235 23090186 20388520 15490108 24632065 16959961 14871415 CYP1A1 IFNG IGF1 IL6 NOS2 NOS3 RELA TGFB1 TNF VEGFA
Colitis	24.79	References/Inference Genes References Inference genes 22410118 24782617 17449036 19238344 24314293 21807089 23810507 24548422 22119709 8698225 IFNG IGF1 IL10 IL4 IL6 NAMPT NOS2 RELA TNF
Atherosclerosis	22.67	References/Inference Genes References Inference genes 20720404 11894143 19330073 9169506 20372816 15937083 12677255 19939336 AGER ESR1 IFNG IL6 NOS2 NOS3 SOCS3 TNF VCAM1 VEGFA
Endometrial neoplasm	22.24	References/Inference Genes References Inference genes 24185510 16804899 26656844 21670700 23200943 17380299 25437045 ESR1 ESR2 HOXA10 HOXA11 MYC PGR SOCS3 VEGFA
Infertility, Female	21.32	References/Inference Genes References Inference genes 21177758 23710174 14684609 19531635 CYP19A1 ESR1 ESR2 LBA MAPK1 MAPK3 PRL
Sepsis	21.17	References/Inference Genes References Inference genes 9806674 11441115 20035746 16003065 8741040 17138957 15489642 IFNG IL10 MAPK1 MAPK3 NOS2 NOS3 TGFB1 TNF

Definition

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Estriol Health Effects

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Estriol Interacts with Diseases

Estriol Interacts with Genes

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Estriol

Definition

Description

Top Gene Interactions

Related Pathways

Estriol Health Effects

General Information

Toxicity

Mechanism of Action

Estriol Interacts with Diseases

Estriol Interacts with Genes

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