ESTRADIOL | SelfDecode | Genome Analysis

Definition

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Growth promoter for livestock. Permitted in the USA Estradiol (E2 or 17?-estradiol, also oestradiol) is a sex hormone. (Wikipedia)

Description

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Top Gene Interactions

Related Pathways

Estrogen Health Effects

Carcinogenic
Topoisomerase-I inhibitor

General Information

Metabolism:
Exogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450. Route of Elimination: Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates. Half Life: 36 hours
Uses/Sources:
For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).
Symptoms:
Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

Mechanism of Action

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Target Name	Mechanism of Action	References
Estrogen receptor Glucocorticoid receptor Estrogen receptor beta Androgen receptor Progesterone receptor Nuclear receptor subfamily 1 group I member 2 Sodium-dependent dopamine transporter Cytochrome P450 2C18		23611293

Estrogen Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Liver Cirrhosis, Experimental	521.49	References/Inference Genes References Inference genes 12389079 16097051 18416461 16465399 21163135 15996030 15745444 16552806 16511523 17404313 15095483 12632514 18263696 18466260 15591519 15197228 15362042 18376398 17072980 16126171 18251166 16642209 16783407 17043671 12586293 17127702 23341968 16953842 16579972 18380797 14716496 15492853 10677585 16549783 25380136 26739621 26435214 18221819 18637143 17565644 11788567 15650968 26806094 12667390 16116963 12918455 16609999 17347453 12609069 16539848 16688825 15793283 15623374 16610050 16085334 15370692 15772939 16025519 16508911 16610064 18458672 16496349 17963606 18555214 18054572 16627068 15661404 15942678 16097045 12557150 17714472 14724832 AADAC ABAT ABCB1 ABCC2 ABCC5 ABCG1 ABCG5 ABCG8 ACAT1 ACHE ACKR3 ACP5 ACTA2 ADA ADAM17 ADD3 ADGRE1 ADH4 ADHFE1 ADIPOQ ADM ADORA2A ADRA1B AFM AFP AGFG1 AGL AGT AHNAK AIF1 AKR1C1 AKR1C3 AKTIP ALB ALDH1A1 ALDH2 AMACR ANGPTL3 ANO6 ANXA1 ANXA2 ANXA3 APOA4 APP ARL11 AS1 ASNS ATF3 BCR BDH1 BICD2 BIRC3 BMF BMP7 C1QA CAMK2D CASP7 CAV1 CCL2 CCL5 CCNB2 CCNG1 CD163 CD36 CD38 CD68 CD83 CD86 CDH5 CDK1 CDKN1A CDKN3 CDO1 CELF2 CHSY1 CMTM3 CNR1 COL12A1 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2 COL6A1 COL6A2 COLEC12 CPS1 CRYAB CSF3 CSGALNACT1 CTGF CTSS CXCL1 CXCL12 CXCL9 CYBA CYP17A1 CYP1A2 CYP26A1 DAO DDC DHRS3 DIO1 DOCK7 DRAM1 ECT2 EDN1 EGF ELOVL5 EMB EMP1 ENPP2 EPB41L2 EPCAM ERAP1 EZR F2R FAM188A FAM49B FAM89A FAT1 FBN1 FGF2 FHL1 FMO1 FOLR2 FOS FOXA2 FRY FYN FZD8 GALC GBP2 GCK GCNT1 GFRA1 GGH GHR GJA1 GJA4 GLS2 GNA14 GOT1 GPAM GPNMB GPT GRN GSN GSTA2 GSTA3 GSTM1 HAL HAO1 HAO2 HELLS HFE2 HGF HIP1 HMOX1 HOPX HPCAL1 HPSE HSD17B6 ID2 ID4 IFNG IFRD1 IGF1 IGF2R IGFBP1 IGFBP2 IGFBP3 IL10 IL18 IL1B IL2RB IL33 IL7R INHBE INMT INS IRF8 ISG20 ISYNA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB6 JAK2 JDP2 KLF6 KNG1 KRT8 KTN1 KYNU LBH LBP LEP LGALS1 LGALS3 LGMN LIMK2 LIN7A LMO2 LOX LOXL2 LPL LTB LTBP1 LUM LURAP1L LY86 MAP3K8 MEOX2 MGMT MGP MITOCHONDRIAL MKI67 MME MMP1 MMP13 MMP15 MMP2 MMP9 MT1A MTMR7 MYC MYO5A NAT8 NBEA NCOR2 NDRG1 NFE2L2 NFKBIA NFKBIZ NID2 NIPAL2 NOS2 NOS3 NQO2 NREP NRG1 NT5E OAT OLFML2B OLFML3 OTC PALMD PAMR1 PCK1 PDGFRA PDGFRB PKLR PLA2G12A PLA2G4A PLAT PLAU PLD4 PLEKHH1 PLG PLOD2 PLTP PMEPA1 POMC PPP1R3B PRKCB PRKCD PRLR PRNP PROCR PRODH PRUNE2 PSMB10 PSMB8 PSMB9 PTGER2 PTGS1 PTGS2 PTN PTPN1 PTPRO PVRL2 RAB30 RAB31 RAB32 RAB8B RABGAP1L RAC2 RAMP1 RARRES1 RECK REEP5 RELA RGS2 RGS5 RMDN2 RPH3AL RTN4 S100A10 S100A6 SERPINA6 SERPINA7 SERPINB9 SERPINH1 SIRT1 SKAP2 SLC17A2 SLC23A1 SLC37A4 SLC39A6 SLC39A8 SLC44A2 SLC46A1 SLC4A4 SMC2 SMOC1 SMOC2 SNX7 SOAT1 SOCS1 SOCS2 SOX4 SREBF1 SRGN STAC3 STARD13 STAU2 STEAP4 SULT2A1 TAP2 TCF4 TGFB1 TGFB3 TGFBR2 THBD TIMP2 TLR4 TMEM43 TNF TNFAIP8 TPM1 TPM4 TRIB3 TRPV1 TSC22D1 TSPAN8 TSPO UBD UNC5CL VEGFA VIM VIPR1 WFDC2 WIPF1 WLS XPNPEP2 YPEL3 YWHAG YWHAZ ZDHHC2 ZEB2
Prostatic Neoplasms	261.86	References/Inference Genes References Inference genes 23996089 14975756 17634423 25908785 16516039 18306354 14754878 15341671 22666205 15389811 18264097 16158739 21903722 15496535 19593445 17192053 19011039 16775185 25246272 11196146 17363613 16877366 16442593 17909013 18225537 20932324 15302576 25237833 18676866 19208208 20140206 12727815 16606632 19074884 9371490 17003774 16222118 17542986 16000583 11275366 19283074 12644816 17115417 17646272 17196815 17728788 20052738 23405127 18500220 17507624 16998812 15598783 18829485 15042602 22919386 17606477 12893367 17332283 17585057 19151717 17916567 17609663 21946351 16809448 11927493 15378487 16083506 23593118 17013881 17566973 17409433 23315858 18082198 17671502 23704919 11742035 16541421 12610512 17826523 21062352 12622714 14678967 18174250 15342424 17502119 15678496 22610119 14973106 25970160 16506214 17785557 15386377 18056468 23441843 16368536 16220300 15138554 12592389 16817226 16266977 25062956 26443449 19240160 12429631 17085659 17220348 21714127 15672864 21456062 17141945 16552752 16427044 15790600 12533788 25320179 19503093 22581815 15538743 16465378 18383875 20729295 17016690 25485837 17914592 17173048 17132221 17639508 15159307 19223546 18798265 20347977 16740699 15948133 24500903 17718901 23248098 16430655 18381416 15643194 20124447 17875776 24763052 16934689 12783936 15583422 26457646 20875869 16406883 16496412 16908180 21743467 17695467 16114055 17176215 17929269 15877079 18264096 21209944 16284379 17202838 17999153 17898866 12618593 24586243 26005866 11222871 12237244 20356562 18304461 16172807 17823934 17804715 23936228 16458450 17288544 15717312 11753679 12445681 16921512 16340751 14666681 15882971 17465268 18559593 17199135 21671747 12210481 16984552 17148459 16813949 15126378 17592021 15318950 15999119 17636462 16859836 16106254 22564066 17704407 10753955 16243370 19396168 16733517 15764345 11454671 17220347 17136230 15616829 25415046 17136762 17465223 19081794 17363566 22159333 16424004 26098866 17919073 12771559 16015594 14968442 16205110 16434975 21716162 15682402 15046698 16421604 25735316 17688413 17301271 17196171 ABCC4 ABCG5 ACE ACHE ACSM3 AGR2 AHR AKR1C3 AKT1 ALAD AMACR ANXA1 ANXA3 AOX1 APEX1 APPL2 ARHGEF5 ATF3 ATM ATP7B AURKA BAD BAX BAZ2A BCAS1 BCL2 BGLAP BMP7 BMPR1B BRCA1 BRCA2 CALCA CALR CASP9 CAV1 CAV2 CBR1 CBX1 CCND1 CCND2 CD82 CD9 CDH1 CDH13 CDKN1A CDKN1B CHEK2 CLDN7 CLIC4 CLU CNN3 COMT CREBBP CRYAB CST6 CTNNB1 CTSB CTSD CXCL12 CXCL8 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP2A6 CYP2C19 CYP2E1 CYP3A4 CYP7B1 DEFB1 DNMT1 EGF EGFR EGR1 EHBP1 EHF EIF2AK2 ELAC2 EMP1 EPCAM EPHX1 ERBB2 ERBB3 ERCC2 ESR1 ESR2 ETV1 EZH2 EZR FASLG FBLN1 FGF10 FGF2 FOXA1 FOXC1 GCNT1 GDF15 GGT1 GHR GJA1 GNMT GPX3 GRB7 GREB1 GSK3B GSTA1 GSTM1 GSTM3 GSTO1 GSTP1 GSTT1 HAO1 HBG1 HBG2 HIF1A HIP1 HMOX1 HPGD HSD17B1 HSD17B3 HSD3B1 HSP90B1 HSPA1A ICAM1 ID3 IGF1 IGFBP3 IGSF5 IL10 IL18 IL1RN IL2 IL24 IL6 INS IRS1 ITGB3 ITPR1 IVNS1ABP JAK2 JUP KLF15 KLF6 KLK2 KLK3 LAMC1 LBA LEP LIFR LPAR1 LPL LRP2 M6PR MAD1L1 MAPK3 MBD2 MDM2 MIF MIF1 MLH1 MME MMP13 MMP9 MPO MSMB MSR1 MUC4 MYC MYH14 NAT1 NAT2 NCOA1 NCOA2 NCOA3 NDRG1 NFE2L2 NFIC NGFR NKX3.1 NOS3 NPPA NPR3 NQO1 NR3C1 NRP1 OLFM1 PARP1 PAWR PCDH8 PDE4DN2 PDHA1 PDZK1 PENK PHGDH PIK3CA PLAU PLAUR PON1 PPARA PPFIBP2 PPP3CA PRKDC PRNP PRRX1 PRSS8 PSCA PTEN PTGS2 PTHLH PTPRK RAB4B RASD1 RLIM RPN2 RRAS RXRA SERINC3 SERPINA3 SERPINE1 SHBG SIRT1 SLC12A2 SLC22A3 SLC31A1 SOD2 SPINK1 SPINK5 SPOCK1 SPON2 SRD5A2 SSBP2 STARD3 STAT3 STEAP4 SULT1A1 SULT2A1 SURF4 TBXAS1 TERT TGFA TGFB1 TGFBR2 TIRAP TLR4 TMEFF2 TMOD1 TMPRSS2 TMSB4X TNFRSF10A TNFRSF21 TNFSF10 TOP2A TP53 TPT1 TRAF1 TYMS UCK2 UGT2B15 UGT2B17 VAV3 VDR VEGFA VIM WNT4 ZBTB16 ZFP36L2 ZIC2
Breast carcinoma	214.64	References/Inference Genes References Inference genes 26587011 22892281 10930538 16870006 14975756 16127422 22370636 16968874 20948315 20103631 12023982 20154269 20421688 15341671 17922014 18297428 24014025 18398872 18497064 22296396 21903722 18488158 15496535 22572619 18925433 18438407 18497072 16175315 23621182 21515334 16799634 10811482 11802810 23146280 20453838 19115204 19552798 22038807 17520698 23921149 25358515 9407957 19636701 9018096 12810669 23867902 23289900 16244791 17047649 15562024 17450141 15375496 20941507 25078270 20400964 19579870 19639193 23535731 19548127 18492817 25267515 12432273 19602265 17043665 16234514 23389445 20228224 19238537 9309585 15894690 11967536 11248153 17659439 19075277 16618760 20179234 16950593 16495393 17426702 15601643 15970926 16322251 19434490 23064031 17285134 19776672 15449313 17570480 27129776 22302033 19839049 16723031 15581045 19756960 23180569 17417639 19436038 15665820 27643540 22174584 10897039 7692001 20458558 25688741 16298037 20008677 16446318 15750629 20562527 12655533 17516992 26229107 16076697 17260099 18498876 20400965 23624423 19234134 19435922 17388661 19196980 21633166 17595805 16792888 11850205 19801490 21119660 16204029 24728294 23342035 24185510 17474063 19330836 20135344 21278746 19288272 22614657 22204715 17965603 23852168 19655245 25322848 19685490 19446661 17132221 25753200 25330770 11970740 7894491 22531848 22267197 7543699 20135347 16091755 25038754 21098263 20479250 24349381 19913079 17634480 20332317 16904380 23535733 20099276 16597321 16077979 19385967 19692670 21638049 12006526 12839951 19671875 21357651 16391819 17529973 26192916 21353530 16280049 15455371 18283316 15802278 24185512 15122511 10788334 20154726 22520950 14672398 16583263 25221644 18819904 23548910 17255770 18840765 21942447 18507500 25151356 11222871 15958052 19896266 17043144 20197467 16255778 19020767 18949741 12926135 16596621 16682728 16865596 18066063 17297925 11237771 17614302 20354179 19968660 20961995 21463514 17529967 21781528 7541186 16137437 21671747 21936542 18521742 14961577 18483385 17520682 24980816 12839489 11583189 18768436 23063927 20061804 17092400 21489049 21501481 22311042 21804546 15994142 18511948 18086299 23001124 26124351 21057462 25751625 15631943 20531310 20179196 15609129 18509974 15706428 23839043 12690581 12517783 20104649 17293864 26379698 16818634 21036696 26437033 16978400 19617202 17200365 16954440 12165863 19652463 26629949 21679465 ABCB1 ABCC1 ABCG2 ACHE ACTA2 ADAMTS1 AFP AGR2 AHR AKAP12 AKT1 AKT2 ALDOA ANGPTL4 APOBEC3B AREG ARRDC3 ATM ATP7B AURKA BARD1 BAX BCHE BCL2 BIRC2 BIRC5 BMP2 BMP4 BMPR2 BRCA1 BRCA2 BRIP1 CASP7 CASP8 CAT CAV1 CCL20 CCND1 CCNE1 CD109 CD40 CDA CDH1 CDH5 CDKN1B CDKN2A CENPF CFL1 CHEK1 CHEK2 CLDN1 COL7A1 COMT CSF1 CSF3 CST6 CTNNB1 CXCL12 CXCL2 CXCL3 CXCL8 CXCL9 CXCR4 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP24A1 CYP3A4 DHFR DIO3 DKK1 DLL1 DNMT1 DNMT3A DPYD E2F1 EDNRB EFEMP1 EFNA1 EGF EGFR EIF2S2 EIF6 ELK3 ENO1 EP300 EPB41L3 EPHB4 ERBB2 ERBB3 ESR1 ESR2 ESRRA ETS2 EVL EXO1 EZH2 F3 FGF10 FGF3 FGF4 FGFR1 FGFR2 FKBPL FLT1 FN1 FOS FOXA1 FOXP3 FOXQ1 FST GDF10 GPNMB GPX1 GPX4 GRB7 GSTP1 GZMB H2AFX HEY2 HEYL HIF1A HIST1H2BC HMMR HMOX1 HP HPSE HRAS HRG HSP90AA1 HSPA1B IBSP ICAM5 IDO1 IFNG IGF1 IGF1R IGFBP5 IL1B IL24 IL6 ITSN2 JAG1 JUN KCNH1 KDR KIT KMT2D KRAS KRT14 KRT5 KRT8 LBA LEP LEPR LOXL2 LPAR1 LSP1 MAP3K1 MDM2 MDM4 MEIS1 MIF MIR146A MKI67 MME MMP1 MMP14 MMP2 MMP-3 MMP9 MTR NAT2 NCOA1 NCOA2 NCOA3 NDRG1 NFKBIA NOS2 NOS3 NOTCH1 NOTCH2 NQO1 NQO2 NRCAM NRG1 NRIP1 PAK1 PARP1 PDZK1 PGR PHB PHGDH PIK3CA PIM1 PLA2G4A PPARGC1B PRC1 PTEN PTGS1 PTGS2 PTHLH RAD51C RAF1 RARA RARB RB1 RELA RGS2 RNF115 SERPINB5 SETBP1 SF4 SFRP1 SFRP2 SIRT1 SLC2A1 SLC2A2 SLC2A5 SLC39A6 SNAI1 SNAI2 SOD2 SPP1 SRC STAT3 STAT5A STC2 SYNE1 SYNJ2 TANK TBX3 TCL1B TERT TFAP2A TFRC TGM2 THBS1 TLE3 TNF TNFSF10 TNIP1 TOP2A TOX3 TP53 TRERF1 TYMS VDR VEGFB VIM WT1 WWOX XRCC2 ZEB1 ZEB2 ZNF365 ZNF366
Endometriosis	171.25	References/Inference Genes References Inference genes 21048224 21232532 21063030 11925390 25446850 23104006 17625110 23284138 20864642 21958689 18815356 19407222 22138541 ABCC4 ABCC9 ABI3BP ACTA2 AKR1C1 AKR1C3 ANKH AREG ARHGAP28 ARNT BMP7 CD55 CLDN1 CNR1 CPM CXCL14 CYB5A CYP19A1 CYP26A1 DDX5 DICER1 DIO2 DKK1 DUSP1 EGFR ENPP1 ERRFI1 ESR2 FBLN1 FBN1 FKBP5 FOS GPX3 GREB1 HBEGF HDAC1 HDAC2 HERC5 HS3ST3B1 HSD17B1 IDO1 IGF1 IGFBP1 IHH IL15 IL1R1 IL7R ITGA2 ITGB1 ITGB8 KLF13 KLF9 KRAS LMOD1 LTF MAOA MAOB MED1 MYLIP NCOA1 NCOA6 NEDD4L NR2F2 NR3C1 NR3C2 NR4A1 NRP1 NTRK3 OLFM4 PAPPA PGR PRL PRLR PTGER2 PTGER4 PTGFR PTGS2 RARB RASGRP1 RGS4 RORB RXFP1 SLC1A1 SLC40A1 SMPDL3A SPARCL1 SRD5A2 STC2 SUCLG2 SULF2 TACSTD2 TAGLN TGFB2 THRA TNC VCAN
Colorectal cancer	144.91	References/Inference Genes References Inference genes 18829568 15172127 16943523 25344691 16879199 21930798 20565773 18703712 16141798 20065508 16963246 20427397 17949449 18676755 17450141 12837940 17047489 15875781 17611699 24836286 21946351 21081473 19223499 15814641 22294766 10072428 18483336 12907644 18716850 20593958 19011631 17187072 15753380 17934461 12645814 17273769 16110022 19296535 7705931 18084292 18850177 17922030 16111806 23431386 23202126 25280562 17656264 15386371 16524972 23977225 17892325 11375891 15954165 26075790 16293616 12637750 18998757 15731169 18497967 15222106 16015041 20346928 10853026 15500737 18949393 16364925 10965019 21278247 18718023 19277044 18267032 18607850 10485483 23548910 16331619 18507500 17943475 21291235 17923031 19020767 16332725 21544799 24976383 18435490 17575224 18413743 21892161 20878130 21369707 19671906 23354438 17982127 16489531 22180778 12690581 23922874 17683511 17684125 ABCA1 ABCA12 ABCA8 ABCB1 ABCB11 ABCC1 ABCC13 ABCC2 ABCC4 ABCC5 ABCC6 ABCC8 ABCG1 ABCG2 ACKR3 ADH1B AKT1 ALDH2 AMACR ARNT ATP7B AURKA AXIN2 BCL2 BIRC5 BMP4 BUB1B CABLES1 CALR CASP8 CCND1 CD109 CD9 CDH1 CDH5 CDH7 CFTR CHEK2 COL7A1 CPAMD8 CTNNB1 CXCL8 CYP1A2 CYP1B1 CYP2A6 DCLK1 DHFR DPYD EFEMP1 EGFR EP300 EPHA1 ERCC2 ESR2 EVL EXO1 EYA4 FADS1 FADS2 FAT1 FBLN2 FBN2 FEN1 FGFR3 FLNC FOXL2 GGH GNB4 GPNMB GPX4 GREM1 GRIN2A GSTM1 GSTM3 HAPLN1 HOXD9 ICAM5 IGF2 IGFBP3 IL6ST KDR KRAS LGR5 MKI67 MLH1 MLH3 MMP1 MMP2 MSH2 NAMPT NME1 NME2 NQO1 NR4A2 NRAS NRCAM NTNG1 NXN OCA ODC1 PDGFRL PIK3CA POSTN PPARG PPM1E PPP1R14A PRKCB PRKCE PRKD1 PROM1 PTGS2 PTPRJ RET RNF43 RRM2 SELENBP1 SERPINB5 SFRP1 SFRP2 SFRP4 SLC19A1 SMAD7 SOD2 SOX17 SYNE1 TCF7L2 TFRC TGFB1 TGFBR1 TLR2 TLR4 TNF TNFSF10 TP53 TP53TG1 TP63 TXNRD1 TYMS WIF1 ZMIZ1
Stomach Neoplasms	143.43	References/Inference Genes References Inference genes 19424620 18652704 25847246 15640503 15138205 15448013 15723263 12588804 19168852 21364753 1733439 17224647 16134180 16314833 15095271 19184424 23382965 21133646 17355264 22490514 10072428 21447133 21628965 15492468 22285823 24816255 12107286 17003101 21936542 25279216 15993841 18593901 19806464 22042947 17571247 22414649 21458988 10853026 21173787 9537325 22385256 10874023 14503839 22484628 18505590 21532492 15940630 11397402 21750908 16367923 26558449 22729845 22039417 21364592 17089033 20061081 19584167 18488030 26401016 17450141 24816253 17786296 10404093 12115524 26098866 19140230 15201584 17575124 23593346 17171786 17963294 18059164 21471434 15378696 17009404 14647439 20729852 15837757 19020767 17387271 ACE ACTC1 ADRB1 AFP AGTR2 AHR AKR1C3 ALB ALDOB ALOX5 APEX1 AREG ATM AURKB BCL2L1 BDNF BIRC2 BIRC5 BMP2 BMP7 CA2 CASP8 CAV1 CCND1 CD44 CDH1 CDH2 CDK4 CDKN1A CDKN1B CDKN2A CHEK2 CKB CTNNA2 CTSC CXCL8 CYP2A6 DLC1 DNMT1 DPYD EEF1A2 EGFR ENO1 ERBB2 ERCC1 ERCC2 F2R FADS1 FAM168A FBP1 FGFR2 FGG FST FYN GLI3 GREM1 GSTP1 HBEGF HMOX1 HRAS HSPB1 HSPD1 HTR1A ID4 IGFBP3 IL1B IL1RN IL32 IL6 IL6R IRS2 ITGA8 JUN KLF6 KMT2A KRAS KRT20 KRT8 LGALS3 M6PR MAPK1 MAPK3 MAPK8 MARK1 MET MLL3 MMP10 MMP7 MTSS1 MUC1 MX1 MYC NOS3 NT5E PA2G4 PDHA1 PHB PIK3CA PLAU PLCE1 PPARG PPIA PRDX5 PRKAA1 PRKCB PRNP PSCA PTGS2 PTPRG RARB RARRES1 RBP1 RBP4 RGS2 RHOA RNF43 RORA RPL18 RPS21 RPS26 RUNX3 SELENBP1 SERPINA1 SERPINE1 SLC1A2 SMOC SNAI1 SOD2 SREBF2 STAT3 SUCLG1 TBX3 TFAP2C TGFA THBD TIMP3 TNF TNFRSF9 TP53 TUBA1C TWIST1 TYMS WIF1 WWOX
Mammary Neoplasms, Animal	124.07	References/Inference Genes References Inference genes 22248470 17173897 14522882 12606953 6280079 12203372 15637090 20235097 9879772 14633621 8603490 18424824 11137312 8185828 15609129 12376462 16316942 ADCY5 ALCAM ANXA1 ANXA2 AQP1 AS1 BASP1 BRCA1 CAPZB CCND1 CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 COMT CSN3 EFEMP1 EGFR ENO1 EPCAM EPHX1 ERBB2 ESR1 ESR2 EZR FABP4 FN FN1 GATA3 GATM GGT1 GSS HBA1 HRAS ID3 ID4 IL6ST INSIG1 KITLG KNG1 KRT5 LIN7A LPL MGP MIF PADI4 PGR PHB PIK3R1 PKM PPARA PRL PRLR PTBP1 PTN RAN RASA1 RB1 RBP1 RBP4 RPL6 RPS14 S100A6 S100A8 SCARB1 SCD SGK1 SLC12A2 SLC25A10 SOX9 SRSF2 STAT3 STAT5A TF THRSP TKT TLE4 TSC22D1 VAMP8 XDH YWHAZ
Hepatocellular carcinoma	111.35	References/Inference Genes References Inference genes 16127164 25496033 27022031 10629087 23242368 15162526 16328049 25822088 25362482 23811326 20084675 11509945 15341023 24012840 15289866 20512989 12532445 12203361 21472284 18425332 17441810 22634754 21785164 20818158 20118494 18477611 21147764 14563831 20698225 19363144 16374840 11286481 16698587 16767786 15276417 22649188 2821104 18019677 22922871 1311924 17191126 19229483 17363595 15057872 19514085 26189965 11896611 12029619 22675488 8200073 18230555 16831601 14578863 15565109 14961299 17978847 9311599 6258829 18559595 9029167 19436114 17510421 18639551 12432545 18553387 16288022 20007298 19731237 21147110 2885971 19919837 17615358 23958494 8033108 25109342 9932610 16092956 11872629 18760346 22022477 20514400 22488367 7892276 22634756 22561517 11563603 20214788 18026104 20506153 22039417 12771043 17326159 12024111 23392203 21056497 16651430 19100240 8364915 16086872 12060674 19146867 ABCB1 ACACA ACE ACO2 ACOX1 ADAMTS1 AFP APCS APEX1 ATM AXIN1 BCL2L1 BIRC5 C9 CA2 CASP8 CBR1 CCNA1 CCND1 CCNE1 CDH13 CDK14 CDK4 CDKN1B CDKN2A CEBPA CEBPB COMT CP CRP CTNNB1 CTSD CXCL12 CXCL8 CYP17A1 CYP1A1 CYP2E1 DPYD E2F1 EGF EGFR ENO1 EPHX1 ESR1 F2 FABP5 FBP1 FDFT1 FGF3 FGF4 FOS FST GDF15 GJB1 GLUL GNMT GPC3 GSTM1 GSTP1 HGF HHIP HRAS HSPA5 HSPA9 HSPB1 IGF1R IGF2 IGF2R IL6 IRS1 IRS2 JDP2 JUN KMT2A KRAS LBA MAT1A ME1 MECP2 MED1 MET MLL3 MMP2 MMP9 MPO MT1A MTOR MVK MYC NFE2L2 NFKBIA NME1 NR1H4 OCA PCK1 PDGFB PDGFRL PGD PHB PIK3CA PKM PKP1 PNPT1 PPARG PTEN PTGS2 PTK2 PYGL RARA RB1 RRM2 SCD SERPINA1 SHH SLC2A1 SLC2A2 SLIT2 SMOC SOCS3 SOD2 SREBF1 SREBF2 STAT1 STAT4 TALDO1 TERT TGFA TGFB1 TH THEM4 TLR4 TNF TNFSF10 TP53 TYMS UBD VCAM1
Carcinoma	110.54	References/Inference Genes References Inference genes 14522882 12606953 10545420 12203372 9062474 11137312 20663906 16316942 24816255 20565773 11196146 15637090 2228319 17520682 21458988 21332314 10853026 11802810 15302576 12376462 10426811 21489049 17173897 23271742 9326929 9879772 20661229 9018096 19028587 9626339 12417722 8185828 8075649 22180778 10485483 17450239 12189197 12216079 11053990 19808899 14633621 10789724 ABCB1 ACKR3 ADCY5 ALCAM ANGPTL4 ANXA1 AQP1 AS1 ATP7B BASP1 BCL2 BCL2L1 BRCA1 CAPZB CCND1 CDC42 CDH1 CDK4 CDS1 CNN3 COL5A1 CSF3 CSN3 DNMT1 EFEMP1 EGFR ENO1 EPCAM EPHX1 ESR1 ESR2 EZR FABP4 FN FN1 GATA3 GATM GGT1 GSS GSTP1 GSTT1 HBA1 HIF1A HRAS ID3 ID4 IL6ST INSIG1 KITLG KRAS KRT5 LIN7A LPL MERTK MET MGP MIF MYC PADI4 PGR PHB PIK3R1 PKM PLAUR PPARA PRLR PTBP1 PTEN PTGS1 PTGS2 PTN RAN RASA1 RB1 RBP1 RBP4 RHOA RPL6 RPS14 S100A6 SCARB1 SCD SGK1 SLC12A2 SLC25A10 SOD2 SOX9 SRSF2 STAT3 STAT5A TF TGFB1 TGFBR2 THRSP TKT TLE4 TLR4 TP53 TP63 TSC22D1 TSHR VAMP8 XDH YWHAZ
Mammary Neoplasms, Experimental	105.45	References/Inference Genes References Inference genes 14522882 12606953 12203372 16322315 22767648 12124350 11137312 15217511 2523869 16316942 11376698 17584969 15637090 21252285 23964924 15528971 12376462 15318939 8389152 9879772 21283680 8185828 15609129 21080969 25221644 16319139 14999141 14633621 8603490 24809783 ABCG2 ADCY5 AFP AGTR2 ALCAM ANXA1 AQP1 AS1 AURKA BASP1 BRCA1 CAPZB CCND1 CD44 CDC42 CDH1 CDK4 CDK6 CDS1 CNN3 COL5A1 CSN3 EFEMP1 EGFR ENO1 EPCAM EPHX1 ERBB2 ESR1 ESR2 EZR FABP4 FN FN1 GATA3 GATM GGT1 GSS HBA1 HMOX1 HRAS ID3 ID4 IGF1 IL10 IL6ST INSIG1 KITLG KRT5 LIN7A LPL MGP MIF MMP9 NCOA1 PADI4 PGR PHB PIK3R1 PKM PPARA PRL PRLR PTBP1 PTK2 PTN RAN RASA1 RB1 RBP1 RBP4 RPL6 RPS14 S100A6 SCARB1 SCD SGK1 SLC12A2 SLC25A10 SOD2 SOX9 SPP1 SRSF2 STAT3 STAT5A TF TFF1 THRSP TKT TLE4 TNFSF10 TSC22D1 VAMP8 XDH YWHAZ
Mesothelioma, Malignant	96.46	References/Inference Genes References Inference genes 19223589 25756049 23056237 11453316 20617513 22784439 27032653 26139392 21543585 25162674 16697254 21526190 26818092 16850164 26928227 20682992 ADAMTS2 AGO1 AGO2 ANXA2 BCL2 C9 CALB2 CCL5 CCL7 CDK6 CDKN1A CDKN2A COL12A1 CSF1 CTNNB1 CXCL12 CXCL8 CXCL9 EFEMP1 EGFR EPHX1 FGD6 FGF18 FGF9 FN1 FTH1 GPR37 GSTM1 HDAC4 HEPH HGF IFNG IL12B IL1A IL4 IL6 KIT LIMCH1 LTA MDK MET MIF MLANA MTMR4 MUC1 NAT2 NGF OSMR PARP1 PDPN PLLP RAF1 RXRA RYR2 SDC1 SLC22A5 SLC2A1 SOD2 TBL1XR1 TF TGFB2 TP53 VIM WNT3 WT1 WWC1
Autism	96.23	References/Inference Genes References Inference genes 17629951 18053270 17349978 18348195 8765331 17404132 19221690 20375269 13680408 17347881 16297937 16721604 15389774 18728693 11354825 16770606 16139734 19195803 20468076 12669065 19058789 18435417 17353214 16472391 16080114 17626784 19401682 19365831 17280648 12746398 20649385 15288368 16724005 19404257 20573161 12579522 18664314 20663923 17383819 18821008 15046869 8964908 19002745 11357950 15830322 17893705 12919132 9804340 19131610 18270976 16917939 15205966 18676531 16720216 18205172 15301788 9152989 19921286 17053076 18762240 18929414 12032595 18759867 20609483 19211884 19265751 18492799 8570775 21328570 15363659 11543639 17033973 21082655 16027737 17918742 15768392 18593506 22490277 11814262 17203304 8098541 11920157 17519220 17509538 11449391 15820235 18957284 15108192 21114665 11496368 20442744 15211631 21359227 18563708 9545402 8071957 18361446 15992526 18207134 17380209 16289943 18090323 16946189 17547689 16360218 18579107 20071347 20662941 12851639 19038234 14755447 19000991 17376794 27082637 17264841 16027742 17597297 11803234 11706102 15446388 18621663 19895723 19360663 19167832 11920158 14659996 17106428 25961944 ABAT ACE ADA ADM ASIC2 ASTN2 ATP10A AVP BCL2 BDNF BTD C3ORF58 CADPS2 CALCA CAT CHRNA4 CHRNA7 CHRNB2 COMT CP CYP19A1 DAB1 DAO DHCR7 DHFR DLX2 DPYD DRD1 DRD3 EGF EGR2 EXT1 FOXP2 GABBR1 GABBR2 GABRA1 GABRA3 GABRA4 GABRA5 GABRB1 GABRB3 GAD1 GHR GJA1 GPR155 GPX1 GRIA1 GRIK2 GRIN2A GSTM1 GSTP1 GZMB HDLBP HLA-A HLA-DRB1 HRAS HTR1B HTR2A IFNG IGF1 IGF2 IGFBP3 IL10 IL15 IL1RN IL2 IL4 IL6 IMMP2L ITGB3 KCNMA1 LASP1 LBA LEP MAOA MAOB MARK1 MBD4 MCC MECP2 MEF2C MET MIF MTF1 MYO1D NBEA NF1 NLGN3 NOS2 NRCAM NTF3 NTRK2 OXTR PASK PCDH10 PDE4B PECAM1 PER1 PITX1 PLA2G4A PLAUR PLD5 POMC PON1 PRKCB PRL PRLR PTEN PTGS2 RIMS1 ROBO1 RORA SERPINE1 SF4 SLC19A1 SLC1A3 SLC40A1 SLC6A4 STK39 STX1A STXBP6 TDO2 TF TNFRSF1B TPH2 UBE3A WNT2 XDH XPC
Rheumatoid arthritis	93.23	References/Inference Genes References Inference genes 21841782 17568789 2001072 16368150 8391952 20476861 23143596 21190368 18617548 11978490 22450443 1568518 16055108 22286218 19192274 16385501 20453842 18794853 22446963 19898480 15292528 23897011 16597321 16872482 20080907 12833524 26001728 17379860 22104130 16729287 12566094 20008919 24313545 23333834 7706905 ABCB1 ABCC2 ABCC4 ABCC5 ABCG2 ACKR3 ADIPOQ ADORA2A AGER AHR ALOX5 ANKRD55 ANXA3 ARID5B B3GNT2 BAIAP2L1 BDKRB2 BLK BMP4 BMP6 CAT CAV2 CCL21 CCL8 CD3E CD40 CD5 CD83 CDK6 CP CRP CTGF CTSD CXCL2 CXCL6 CXCL8 CXCR4 DDIT4 DDX6 DFNA5 DHFR ENO1 F2 FASLG FKBP5 FOXP3 GATA3 GGH GPRC5A HAPLN1 HLA-DRB1 HOXD10 HSD11B1 IFNG IGFBP3 IL10 IL18 IL1B IL1RN