Definition
The S-isomer of omeprazole.
Description
Esomeprazole is only found in individuals that have used or taken this drug. It is a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [PubChem]Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
Top Gene Interactions
General Information
- Metabolism: Mainly hepatic. Esomeprazole is completely metabolized by the cytochrome P450 system via CYP2C19 and CYP3A4. Metabolism produces inactive hydroxy and desmethyl metabolites, which have no effect on gastric acid secretion. Less than 1% of the parent drug is excreted in urine. Route of Elimination: Approximately 80% of the administered dose of esomeprazole is excreted as metabolites in urine and the remaining 20% is excreted in feces. Half Life: 1-1.5 hours
- Uses/Sources: Used in the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use. Used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. [Wikipedia]
- Health Effects: Blurred vision, confusion, drowsiness, dry mouth, flushing headache, nausea, rapid heartbeat, sweating.
- Symptoms: Blurred vision, confusion, drowsiness, dry mouthflushingheadache, nausea, rapid heartbeat, sweating.
- Route of Exposure: Oral
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Cytochrome P450 3A4 Potassium-transporting ATPase subunit beta Multidrug resistance protein 1 Cytochrome P450 2C9 |
2842503 2836591 14761192 12477351 11770010 19128860 9873457 9022797 |
|
Sodium/potassium-transporting ATPase subunit alpha-1 Potassium-transporting ATPase alpha chain 1 Potassium-transporting ATPase alpha chain 2 |
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity. |
15774534 16109841 16307499 14752612 17458401 15496215 15498502 15258107 11752352 16207309 |
Esomeprazole Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Hyperoxia | 6.14 |
|
Hamartoma | 6.05 |
|
Arteritis | 5.45 |
|
Peripheral Vascular Diseases | 5.17 |
|
Occupational Diseases | 4.92 |
|
Tachycardia, Sinus | 4.78 |
|
Chronic obstructive pulmonary disease | 4.73 |
|
Kidney Neoplasms | 4.5 |
|
Lung Injury | 4.48 |
|
Male infertility | 4.47 |
|
Abortion, Spontaneous | 4.41 |
|
Dermatitis, Contact | 4.38 |
|
Micronuclei, Chromosome-Defective | 4.37 |
|
Allergy | 4.34 |
|
Long QT Syndrome | 4.3 |
|
Diabetes Mellitus, Experimental | 4.22 |
|
Drug Eruptions | 4.18 |
|
Cardiac hypertrophy | 4.17 |
|
Dermatitis, Allergic Contact | 4.12 |
|
Hepatocellular carcinoma | 3.86 |
|