Definition
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Occurs in several higher plants, such as banana (Musa sapientum) As a member of the catecholamine family, dopamine is a precursor to norepinephrine (noradrenaline) and then epinephrine (adrenaline) in the biosynthetic pathways for these neurotransmitters.
Description
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem]
Dopamine is Found in These Foods
Top Gene Interactions
Related Pathways
Dopamine Health Effects
General Information
- Metabolism: Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA). Route of Elimination: It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged. Half Life: 2 minutes
- Uses/Sources: For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
- Health Effects: Chronically high levels of dopamine are associated with at least 2 inborn errors of metabolism including: Aromatic L-Amino acid Decarboxylase Deficiency and Norepinephrine deficiency.
- Route of Exposure: Dopamine is rapidly absorbed from the small intestine.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD<sub>50</sub> oral mice = 1460 mg/kg, LD<sub>50</sub> oral rats = 1780 mg/kg
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Dopamine beta-hydroxylase 5-hydroxytryptamine receptor 1A Sodium-dependent serotonin transporter Sodium-dependent dopamine transporter Sodium-dependent noradrenaline transporter Synaptic vesicular amine transporter 5-hydroxytryptamine receptor 7 D(2) dopamine receptor D(3) dopamine receptor D(4) dopamine receptor 5-hydroxytryptamine receptor 1F D(1A) dopamine receptor D(1B) dopamine receptor Tyrosine-protein kinase Fyn D(1) dopamine receptor |
8398139 9784114 15985612 17301410 17394052 7658429 3156993 23134120 17287146 7912402 9686407 23727194 11206464 17258889 9185324 22846798 17449449 23428965 17455212 19439595 11752352 8893836 17625104 8302271 18834111 17433386 10465538 17468175 1973733 20155917 10691700 19454369 10411589 17561816 8394362 17145705 14592523 8632409 1826762 11071707 15801855 1831904 |