Top Gene Interactions
- Metabolism: Dimethyl sulfoxide is metabolized in man by oxidation to dimethyl sulfone or by reduction in dimethyl sulfide. Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces. Route of Elimination: Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces.
- Uses/Sources: DMSO is an important polar aprotic solvent. In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions.[Wikipedia]
- Symptoms: Taking DMSO internally is reported to cause a fish- or oyster-like taste or odor in the mouth, likely due to the sulfoxide metabolites of DMSO. [Wikipedia]
- Treatment: In case of accidental oral ingestion, specifc measures should be taken to induce emesis. Additional measures which may be considered are gastric lavage, activated charcoal and force diuresis. (L1712)
- Route of Exposure: Topical ; parenteral(intravesical). Readily and rapidly absorbed following administration by all routes and distributed throughout the body.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50: >10 gm/kg (Oral, Dog) (A308)
Mechanism of Action
|Target Name||Mechanism of Action||References|
|Insulin-like growth factor-binding protein 5||
Peptidyl-prolyl cis-trans isomerase FKBP1A
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Aldo-keto reductase family 1 member C3
Alcohol dehydrogenase E chain
Plasminogen activator inhibitor 1
Triosephosphate isomerase, glycosomal
Peptidyl-prolyl cis-trans isomerase FKBP4
|The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action.||