Definition
A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Description
Digitoxin is only found in individuals that have used or taken this drug. It is a cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)Digitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic.
- Uses/Sources: For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Sodium/potassium-transporting ATPase subunit alpha-1 Signal transducer and activator of transcription 1-alpha/beta |
136410 17145705 131389 19751721 123547 11309248 132355 |