Definition
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Description
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic. Route of Elimination: Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites. Half Life: 2 hours
- Uses/Sources: For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
- Symptoms: Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis.
- Route of Exposure: Completely absorbed from the gastrointestinal tract.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD<sub>50</sub>=390mg/kg (orally in mice)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Sodium channel protein type 4 subunit alpha Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 3 Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Arachidonate 5-lipoxygenase Phospholipase A2, membrane associated Acid-sensing ion channel 1 |
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