Top Gene Interactions
- Metabolism: Hepatic. Route of Elimination: Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites. Half Life: 2 hours
- Uses/Sources: For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
- Symptoms: Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis.
- Route of Exposure: Completely absorbed from the gastrointestinal tract.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD<sub>50</sub>=390mg/kg (orally in mice)
Mechanism of Action
|Target Name||Mechanism of Action||References|
Sodium channel protein type 4 subunit alpha
Potassium voltage-gated channel subfamily KQT member 2
Potassium voltage-gated channel subfamily KQT member 3
Prostaglandin G/H synthase 1
Prostaglandin G/H synthase 2
Phospholipase A2, membrane associated
Acid-sensing ion channel 1