Top Gene Interactions
- Metabolism: Hepatic.
- Uses/Sources: For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
- Route of Exposure: Less than 20% of the orally administered dose is absorbed from the gastrointestinal tract.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Cytarabine syndrome may develop - it is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise.
Mechanism of Action
|Target Name||Mechanism of Action||References|
DNA polymerase beta