Definition
Description
Top Gene Interactions
Related Pathways
Cysteine Health Effects
General Information
- Metabolism: Uremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces.
- Uses/Sources: For the prevention of liver damage and kidney damage associated with overdoses of acetaminophen
- Health Effects: Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
- Symptoms: As a uremic toxin, this compound can cause uremic syndrome. Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma. Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury can also occur. Heart problems, such as an irregular heartbeat, inflammation in the sac that surrounds the heart (pericarditis), and increased pressure on the heart can be seen in patients with uremic syndrome. Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion) can also be present.
- Treatment: Kidney dialysis is usually needed to relieve the symptoms of uremic syndrome until normal kidney function can be restored.
- Route of Exposure: Endogenous, Ingestion, Dermal (contact)
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Thiamine transporter 2 Cystathionine beta-synthase Cystine/glutamate transporter Kinesin-like protein KIF11 Solute carrier family 22 member 8 Cysteine--tRNA ligase, cytoplasmic Glutamate--cysteine ligase regulatory subunit Glutamate--cysteine ligase catalytic subunit Cysteine dioxygenase Aspartate aminotransferase, cytoplasmic Cystathionine gamma-lyase Cysteine dioxygenase type 1 Methylated-DNA--protein-cysteine methyltransferase Glutathione synthetase Probable cysteine--tRNA ligase, mitochondrial Cysteine sulfinic acid decarboxylase Cysteine desulfurase, mitochondrial Proton-coupled amino acid transporter 1 Klotho NADPH oxidase 4 |
16108046 17488480 15671155 16492780 17135237 17634391 15985427 17524640 16877383 17657274 15695431 25041433 16940754 17469805 15828873 19932968 17377202 17615559 16428267 7131091 17602574 16781459 16603772 16950796 17016423 17139284 6953423 22419041 21955456 16355974 236774 |
Cysteine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Liver Cirrhosis, Experimental | 51.09 |
|
Lung Neoplasms | 42.16 |
|
Diabetes Mellitus, Experimental | 41.75 |
|
Alcoholic liver cirrhosis | 41.73 |
|
Diabetes Mellitus, Type 2 | 40.78 |
|
Brain Ischemia | 35.99 |
|
Hepatocellular carcinoma | 35.84 |
|
Breast carcinoma | 33.53 |
|
Reperfusion Injury | 30.07 |
|
Prostatic Neoplasms | 29.84 |
|
Hypertension | 28.76 |
|
Calcinosis | 27.62 |
|
Marfan Syndrome | 26.94 |
|
Kidney Neoplasms | 26.58 |
|
Neoplasm Invasiveness | 26.42 |
|
Colonic neoplasm | 26.35 |
|
Colorectal cancer | 26.03 |
|
Myocardial infarction | 26.0 |
|
Myocardial Ischemia | 25.09 |
|
Oral Submucous Fibrosis | 25.06 |
|