Top Gene Interactions
- Metabolism: Primarily hepatic. Cyproterone acetate is metabolized by the CYP3A4 enzyme, forming the active metabolite 15beta-hydroxycyproterone acetate, which retains its antiandrogen activity, but has reduced progestational activity. Route of Elimination: It is excreted approximately 60% in the bile and 33% through the kidneys. Half Life: Elimination Following oral or intramuscular administration, the plasma half-life is 38 and 96 hours, respectively.
- Uses/Sources: For the palliative treatment of patients with advanced prostatic carcinoma.
- Route of Exposure: Completely absorbed following oral administration.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Cyproterone Acetate Interacts with Diseases
|Disease||Inference Score||References/Inference Genes|
|Urinary Bladder Neoplasms||9.83|
|Mammary Neoplasms, Experimental||9.8|
|Leydig Cell Tumor||8.92|
|Cell Transformation, Neoplastic||7.6|