Definition
Trace constit. of ginger oil (Zingiber officinale) Cumene is the common name for isopropylbenzene, an organic compound that is an aromatic hydrocarbon. It is a constituent of crude oil and refined fuels. It is a flammable colorless liquid that has a boiling point of 152 °C. Nearly all the cumene that is produced as a pure compound on an industrial scale is converted to cumene hydroperoxide, which is an intermediate in the synthesis of other industrially important chemicals such as phenol and acetone.
Description
Isopropylbenzene is found in ceylan cinnamon. Isopropylbenzene is a trace constituent of ginger oil (Zingiber officinale) Cumene is the common name for isopropylbenzene, an organic compound that is an aromatic hydrocarbon. It is a constituent of crude oil and refined fuels. It is a flammable colorless liquid that has a boiling point of 152 C. Nearly all the cumene that is produced as a pure compound on an industrial scale is converted to cumene hydroperoxide, which is an intermediate in the synthesis of other industrially important chemicals such as phenol and acetone. Isopropylbenzene has been shown to exhibit catabolic function (A7843).
Top Gene Interactions
Related Pathways
Cumene Health Effects
General Information
- Metabolism: Volatile hydrocarbons are absorbed mainly through the lungs, and may also enter the body after ingestion via aspiration. (A600)
- Uses/Sources: Isopropylbenzene is a component of gasoline. Nearly all the cumene that is produced as a pure compound on an industrial scale is converted to cumene hydroperoxide, which is an intermediate in the synthesis of other industrially important chemicals such as phenol and acetone. (L1300)
- Health Effects: Petroleum distillates are aspiration hazards and may cause pulmonary damage, central nervous system depression, and cardiac effects such as cardiac arrhythmias. They may also affect the blood, immune system, liver, and kidney. (A600, L1297)
- Symptoms: Petroleum distillate poisoning may cause nausea, vomiting, cough, pulmonary irritation progressing to pulmonary edema, bloody sputum, and bronchial pneumonia. At high amounts, central nervous system depression may also occur, with symptoms such as weakness, dizziness, slow and shallow respiration, unconsciousness, and convulsions. Petroleum distillates are also irritating to the skin. (A594)
- Treatment: Treatment is mainly symptomatic and supportive. Gastric lavage, emesis, and the administration of activated charcoal should be avoided, as vomiting increases the risk of aspiration. (A600)
- Route of Exposure: Oral (L400) ; inhalation (L400) ; dermal (L400)
Toxicity
- Carcinogenicity: 2B, possibly carcinogenic to humans. (L135)
- Toxicity: LD50: 1400 mg/kg (Oral, Rat) (T14) LC50: 24 700 mg/m3 over 2 hours (Inhalation, Mouse) (T14)
Cumene Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Breast carcinoma | 43.16 |
References/Inference Genes
|
Liver Cirrhosis, Experimental | 25.12 | |
Stomach Neoplasms | 23.4 | |
Carcinoma, Non-Small-Cell Lung | 22.43 | |
Ovarian Neoplasms | 21.24 | |
Carcinoma | 19.37 | |
Hepatocellular carcinoma | 19.29 | |
Squamous cell carcinoma | 17.72 | |
Arthritis, Juvenile | 16.03 |
|
Prostatic Neoplasms | 15.92 | |
Adenocarcinoma | 15.79 | |
Endometriosis | 14.87 | |
Mammary Neoplasms, Animal | 14.37 | |
Lung adenocarcinoma | 14.0 | |
Liver Neoplasms | 13.61 | |
Cirrhosis, Familial | 13.56 |
|
Mammary Neoplasms, Experimental | 12.52 |
References/Inference Genes
|
Myocardial Ischemia | 11.54 |
|
Neoplasm Metastasis | 11.45 | |
Protoporphyria, Erythropoietic | 11.41 |
|