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Interaction | References |
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[5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in increased mutagenesis of MET protein] which results in decreased susceptibility to crizotinib | R |
Interaction | References |
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crizotinib results in decreased activity of ALK protein mutant form | R |
Interaction | References |
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crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK1 protein] | R |
Interaction | References |
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crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK3 protein] | R |
Interaction | References |
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EGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib] | R |
Interaction | References |
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EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib] | R |
Interaction | References |
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[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein | R |
Interaction | References |
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EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein] | R |
Interaction | References |
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EGFR protein mutant form results in decreased susceptibility to crizotinib | R |
Interaction | References |
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BCL2L11 protein affects the reaction [crizotinib results in increased cleavage of CASP3 protein] | R |