Definition
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem; There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs.; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia; An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.; Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athlete's foot and jock itch. [HMDB]
Description
Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs. Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athlete's foot and jock itch.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic (metabolized to inactive metabolites) Half Life: 2 hours
- Uses/Sources: For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
- Symptoms: Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
- Route of Exposure: Poorly and erratically absorbed orally, minimal vaginal or topical absorption.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Estrogen receptor Aryl hydrocarbon receptor Cytochrome P450 3A4 Cytochrome P450 19A1 Multidrug resistance protein 1 Potassium voltage-gated channel subfamily A member 3 Nuclear receptor subfamily 1 group I member 2 Lanosterol 14-alpha demethylase Cytochrome P450 3A3 Cytochrome P450 2D6 Cytochrome P450 2C9 Cytochrome P450 2C19 Nuclear receptor subfamily 1 group I member 3 Nuclear factor erythroid 2-related factor 2 Bile acid receptor Hypoxia-inducible factor 1-alpha Steroid 17-alpha-hydroxylase/17,20 lyase Malate dehydrogenase, cytoplasmic C-X-C chemokine receptor type 1 Vasopressin V2 receptor C-C chemokine receptor type 4 |
19282171 20869355 23437772 23611293 23015691 12773039 12699389 20413308 8917702 23688559 15849716 19128860 14977870 17194716 14521410 |
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Intermediate conductance calcium-activated potassium channel protein 4 | Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel. |
19282171 11752352 18232633 |
Clotrimazole Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Prostatic Neoplasms | 43.2 |
References/Inference Genes
|
Liver Cirrhosis, Experimental | 38.06 | |
Breast carcinoma | 25.95 |
References/Inference Genes
|
Hepatocellular carcinoma | 25.32 | |
Osteosarcoma | 24.25 | |
Diabetes Mellitus, Experimental | 23.09 | |
Drug-induced liver injury | 22.72 | |
Diabetes Mellitus, Type 2 | 22.43 | |
Acute lymphoblastic leukemia | 20.29 | |
Reperfusion Injury | 20.07 | |
Lung Neoplasms | 19.01 | |
Carcinoma, Non-Small-Cell Lung | 17.85 | |
Stomach Neoplasms | 17.56 | |
Colonic neoplasm | 17.17 | |
Colorectal cancer | 16.92 | |
Esophageal Neoplasms | 16.48 | |
Nervous System Diseases | 16.38 | |
Myocardial Ischemia | 16.19 | |
Neoplasm Metastasis | 16.01 | |
Status Epilepticus | 15.98 |