Description
Cinnamaldehyde is the aldehyde that gives cinnamon its flavor and odor. Cinnamaldehyde occurs naturally in the bark of cinnamon trees and other species of the genus Cinnamomum like camphor and cassia. These trees are the natural source of cinnamon, and the essential oil of cinnamon bark is about 90% cinnamaldehyde. Cinnamaldehyde is also used as a fungicide. Proven effective on over 40 different crops, cinnamaldehyde is typically applied to the root systems of plants. Its low toxicity and well-known properties make it ideal for agriculture. To a lesser extent, cinnamaldehyde is an effective insecticide, and its scent is also known to repel animals like cats and dogs. Cinnamaldehyde is also known as a corrosion inhibitor for steel and other ferrous alloys in corrosive fluids. It can be used in combination with additional components such as dispersing agents, solvents and other surfactants. Concentrated cinnamaldehyde is a skin irritant, and the chemical is toxic in large doses, but no agencies suspect the compound is a carcinogen or poses a long-term health hazard. Most cinnamaldehyde is excreted in urine as cinnamic acid, an oxidized form of cinnamaldehyde.
Top Gene Interactions
Related Pathways
Cinnamon (Cinnamaldehyde) Health Effects
- Acaricide
- Adrenergic
- Allergenic
- Anesthetic
- Anti enterococcic
- Anti escherichic
- Anti herpetic
- Anti inflammatory
- Anti leukemic
- Anti pneumonic
- Anti pseudomonic
- Anti pyretic
- Anti salmonella
- Anti spasmodic
- Anti staphylococcic
- Anti ulcer
- Anti urease
- Anti viral
- Cancer preventive
- Candidicide
- Choleretic
- Circulatory stimulant
- Central nervous system depressant
- Central nervous system stimulant
- Cyclooxygenase-2 inhibitor
- Cyclooxygenase inhibitor
- Cytotoxic
- Flavor
- Fungicide
- Herbicide
- Hypoglycemic
- Hypotensive
- Hypothermic
- Insecticide
- Irritant
- Lipoxygenase inhibitor
- Monoaminergic
- Nematicide
- Perfumery
- Pesticide
- Sedative
- Sprout inhibitor
- Teratogenic
- Termiticide
- Tranquilizer
- Tyrosinase inhibitor
- Vasodilator
- Allelochemic
- Anti aggregant
- Anti bacterial
- Vibriocide
- Anti klebsiellic
- Anti mutagenic
- Chronotropic
- Histaminic
- Inotropic
- Mutagenic
General Information
- Metabolism:
Cinnamaldehyde is converted to cinnamoyl-CoA by cinnamoyl-CoA reductase.
- Health Effects: Allergic reaction.
- Symptoms:
The specific symptoms that can result from cinnamic aldehyde allergy can vary considerably amongst patients from a severe anaphylactic reaction to asthma, abdominal symptoms, eczema or headaches. (L2140)
- Route of Exposure:
Inhalation; dermal; ingestion
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50: 3400 mg/kg (rat, oral)
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Glutathione S-transferase P Thromboxane A2 receptor |
17079160 9463521 |
Cinnamon (Cinnamaldehyde) Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Diabetes Mellitus, Experimental | 70.93 |
|
| Brain Ischemia | 65.63 |
|
| Reperfusion Injury | 64.87 |
|
| Breast carcinoma | 57.33 |
|
| Liver Cirrhosis, Experimental | 56.48 |
|
| Prostatic Neoplasms | 55.11 |
|
| Hepatocellular carcinoma | 54.22 |
|
| Lung Neoplasms | 52.7 |
|
| Cell Transformation, Neoplastic | 52.28 |
|
| Stomach Neoplasms | 47.89 |
|
| Dermatitis, Contact | 45.91 |
|
| Obesity | 45.78 |
|
| Mesothelioma, Malignant | 40.98 |
|
| Carcinoma, Non-Small-Cell Lung | 40.45 |
|
| Colonic neoplasm | 40.13 |
|
| Diabetes Mellitus, Type 2 | 38.92 |
|
| Inflammation | 34.38 |
|
| Myocardial Ischemia | 32.18 |
|
| Kidney Failure, Chronic | 31.49 |
|
| Hypertension | 30.97 |
|