Definition
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Description
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985).
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Route of Elimination: Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard. The pharmacokinetic data suggests that oral chlorambucil undergoes rapid gastrointestinal absorption and plasma clearance and that it is almost completely metabolized, having extremely low urinary excretion. Half Life: 1.5 hours
- Uses/Sources: For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenstrн_mду»s Macroglobulinemia.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
DNA |
20350810 17139284 9031099 17016423 19749264 14871502 |
Chlorambucil Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Carcinoma, Non-Small-Cell Lung | 26.05 | |
Colorectal cancer | 23.52 | |
Breast carcinoma | 22.38 |
References/Inference Genes
|
Esophageal Neoplasms | 21.87 | |
Carcinoma, squamous cell of head and neck | 20.83 | |
Non-alcoholic fatty liver disease | 20.26 | |
Hepatocellular carcinoma | 19.74 | |
Prostatic Neoplasms | 17.54 |
References/Inference Genes
|
Dermatitis, Contact | 16.95 |
|
Lung Neoplasms | 14.25 | |
Disease Progression | 14.04 | |
Esophageal squamous cell carcinoma | 13.78 |
References/Inference Genes
|
Keratosis | 13.36 |
|
Adenocarcinoma | 13.14 | |
Colonic neoplasm | 12.66 | |
Mesothelioma, Malignant | 12.54 | |
Squamous cell carcinoma | 12.45 | |
Lymphoma, Large B-Cell, Diffuse | 11.82 |
References/Inference Genes
|
Diabetes Mellitus, Type 2 | 11.63 | |
Gallbladder neoplasm | 11.4 |
References/Inference Genes
|