Definition
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Brompheniramine (also known as Bromfed, Bromfenex, and Dimetane) is an antihistamine drug of the propylamine class. It is commonly available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine; Brompheniramine (also known as Bromfed, Bromfenex, and Dimetane) is an antihistamine drug of the propylamine class. It is commonly available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine. -- Wikipedia; Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [HMDB]
Description
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [PubChem]
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic (cytochrome P-450 system), some renal.
- Uses/Sources: For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
- Symptoms: Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
- Route of Exposure: Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral, Rat: LD<sub>50</sub> = 318 mg/kg.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Muscarinic acetylcholine receptor M1 Muscarinic acetylcholine receptor M2 Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M4 Muscarinic acetylcholine receptor M5 Histamine H1 receptor |
1970615 11752352 7714410 7855217 10212017 1680053 |
Brompheniramine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Torsades de pointes | 8.97 |
|
Long QT Syndrome | 8.74 |
|
Cardiomyopathy, Dilated, 1E | 7.52 |
|
Long Qt Syndrome 3 | 7.52 |
|
Long QT syndrome type 3 | 7.52 |
|
Sick Sinus Syndrome 1, Autosomal Recessive | 7.52 |
|
Paroxysmal ventricular fibrillation | 7.18 |
|
PROGRESSIVE FAMILIAL HEART BLOCK, TYPE IA | 7.18 |
|
Short QT Syndrome 1 | 6.89 |
|
Long Qt Syndrome 2 | 6.2 |
|
Sudden Infant Death | 6.2 |
|
Brugada syndrome | 6.14 |
|
Atrial fibrillation | 4.92 |
|
Tachycardia, Ventricular | 4.81 |
|
Muscular Atrophy | 4.79 |
|
Cell Transformation, Neoplastic | 4.08 |
|
Colonic neoplasm | 4.02 |
|
Cardiac arrhythmia | 3.91 |
|
Neoplasms | 3.86 |
|
Poisoning | 3.85 |
|