Definition
Description
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic Route of Elimination: It was reported that patients with moderately severe renal failure excreted less than 20% of the dose in the urine. Half Life: 115 minutes
- Uses/Sources: For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
- Health Effects: The most serious complication of bleomycin is pulmonary fibrosis and impaired lung function. (Wikipedia) Bleomycin can also induce scleroderma (A15410, A15408).
- Symptoms: Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.
- Route of Exposure: Intravenous; systemic absorption is approximately 45%.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Transient receptor potential cation channel subfamily A member 1 DNA |
18757754 21078588 18597467 6177398 19146404 |
|
DNA ligase 3 DNA ligase 1 |
Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. |
17202402 |