Definition
Widespread isoflavone found in alfalfa (Medicago sativa), chick peas (Cicer arietinum) and white clover (Trifolium repens). Glycosides also widespread. Potential nutriceutical The phytoestrogen biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Treating MCF-7 human breast carcinoma cells with biochanin A alone caused the accumulation of CYP1A1 mRNA and an increase in CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity in a dose dependent manner. Biochanin A may be a natural ligand to bind on aryl hydrocarbon receptor acting as an antagonist/agonist of the pathway. (PMID: 16903077); Biochanin A suppress nuclear factor-kappaB-driven interleukin-6 (IL6) expression. In addition to its physiologic immune function as an acute stress cytokine, sustained elevated expression levels of IL6 promote chronic inflammatory disorders, aging frailty, and tumorigenesis. (PMID: 16651441); Biochanin A induces a decrease in invasive activity of U87MG cells in a dose-related manner. (PMID: 16598420); Biochanin A activates peroxisome proliferator-activated receptors (PPAR) PPARalpha, PPARgamma, and adipocyte differentiation in vitro of 3T3-L1 preadipocytes, suggesting potential value of isoflavones, especially biochanin A and their parent botanicals, as antidiabetic agents and for use in regulating lipid metabolism. (PMID: 16549448)
Description
The phytoestrogen biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Treating MCF-7 human breast carcinoma cells with biochanin A alone caused the accumulation of CYP1A1 mRNA and an increase in CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity in a dose dependent manner. Biochanin A may be a natural ligand to bind on aryl hydrocarbon receptor acting as an antagonist/agonist of the pathway. (A7920). Biochanin A suppress nuclear factor-kappaB-driven interleukin-6 (IL6) expression. In addition to its physiologic immune function as an acute stress cytokine, sustained elevated expression levels of IL6 promote chronic inflammatory disorders, aging frailty, and tumorigenesis. (A7921). Biochanin A induces a decrease in invasive activity of U87MG cells in a dose-related manner. (A7922). Biochanin A activates peroxisome proliferator-activated receptors (PPAR) PPARalpha, PPARgamma, and adipocyte differentiation in vitro of 3T3-L1 preadipocytes, suggesting potential value of isoflavones, especially biochanin A and their parent botanicals, as antidiabetic agents and for use in regulating lipid metabolism. (A7923).
Top Gene Interactions
Related Pathways
Biochanin A Health Effects
- 17beta-hydroxysteroid-dehydrogenase inhibitor
- 5alpha-reductase inhibitor
- Alpha-reductase inhibitor
- Anti alcoholic
- Anti carcinogenic
- Anti cephalagic
- Anti proliferant
- Anti prostat adenomic
- Anti prostatitic
- Antitumor
- Aromatase inhibitor
- Cancer preventive
- Chemopreventive
- Estrogen receptor beta binder
- Estrogen agonist
- Flatulent
- Fungicide
- Fungistat
- Herbicide
- Hypocholesterolemic
- Hypolipidemic
- Pesticide
- Topoisomerase-II inhibitor
- Topoisomerase-I inhibitor
- Utero trophic
- VAM simulant
- Anti mutagenic
- Apoptotic
General Information
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Estrogen receptor Estrogen receptor beta Aryl hydrocarbon receptor Androgen receptor Steroid hormone receptor ERR1 Steroid hormone receptor ERR2 Progesterone receptor Peroxisome proliferator-activated receptor alpha Cytochrome P450 19A1 Translocator protein Bile acid receptor ATPase family AAA domain-containing protein 5 |
14579009 9751507 14638870 23611293 16076101 9435150 |
Biochanin A Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Prostatic Neoplasms | 54.22 |
|
Breast carcinoma | 47.23 |
|
Diabetes Mellitus, Experimental | 34.52 |
|
Reperfusion Injury | 31.24 |
|
Brain Ischemia | 29.29 |
|
Stomach Neoplasms | 26.98 |
|
Hepatocellular carcinoma | 25.96 |
|
Adenocarcinoma | 24.57 |
|
Colonic neoplasm | 23.85 |
|
Colorectal cancer | 23.53 |
|
Neoplasm Metastasis | 22.37 |
|
Ulcerative colitis | 22.28 |
|
Obesity | 21.8 |
|
Liver Cirrhosis, Experimental | 20.38 |
|
Hypertension | 20.09 |
|
Chronic obstructive pulmonary disease | 19.8 |
|
Diabetes Mellitus, Type 2 | 19.57 |
|
Inflammation | 18.96 |
|
Cell Transformation, Neoplastic | 18.65 |
|
Endometriosis | 18.45 |
|