Top Gene Interactions
- Metabolism: Bicalutamide undergoes stereo specific metabolism. The S (inactive) isomer is metabolized primarily by glucuronidation. The R (active) isomer also undergoes glucuronidation but is predominantly oxidized to an inactive metabolite followed by glucuronidation. Half Life: 5.9 days
- Uses/Sources: For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
- Route of Exposure: Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Estrogen receptor beta
Nuclear receptor subfamily 1 group I member 2