Definition
Constit. of bergamot oil. Also from lemon oil and oils of other Citrus spp. and carrot (Daucus carota) Bergamottin is a natural furanocoumarin found principally in grapefruit juice. It is also found in the oil of bergamot, from which it was first isolated and from which its name is derived. To a lesser extent, bergamottin is also present in the essential oils of other citrus fruits. Along with the chemically related compound 6?,7?-dihydroxybergamottin, it is believed to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.
Description
Bergamottin is found in citrus. Bergamottin is a constituent of bergamot oil. Also from lemon oil and oils of other Citrus species and carrot (Daucus carota) Bergamottin is a natural furanocoumarin found principally in grapefruit juice. It is also found in the oil of bergamot, from which it was first isolated and from which its name is derived. To a lesser extent, bergamottin is also present in the essential oils of other citrus fruits. Along with the chemically related compound 6 ,7 -dihydroxybergamottin, it is believed to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs. Bergamottin has been shown to exhibit anti-tumor function (A7783).
Top Gene Interactions
Related Pathways
Bergamottin Health Effects
General Information
- Health Effects: The furocoumarin 8-methoxypsoralen is carcinogenic to humans, and possibly 5-methoxypsoralen as well (L135). There is some evidence from mouse studies that other furocoumarins are carcinogenic when combined with exposure to UVA radiation (A15105). The SKLM regards the additional risk of skin cancer arising from the consumption of typical quantities of furocoumarin-containing foods, which remain significantly below the range of phototoxic doses, as insignificant. However, the consumption of phototoxic quantities cannot be ruled out for certain foods, particularly celery and parsnips, that may lead to significant increases in furocoumarin concentrations, depending on the storage, processing and production conditions. (L2157) Furocoumarin photochemotherapy is known to induce a number of side-effects including erythema, edema, hyperpigmentation, and premature aging of skin. All photobiological effects of furocoumarins result from their photochemical reactions. Because many dietary or water soluble furocoumarins are strong inhibitors of cytochrome P450s, they will also cause adverse drug reactions when taken with other drugs.
Bergamottin Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Breast carcinoma | 16.49 |
|
| Dermatitis, Contact | 16.04 |
|
| Hyperoxia | 12.99 |
|
| Acute lymphoblastic leukemia | 12.04 |
|
| Lung Injury | 11.89 |
|
| Drug-induced liver injury | 11.06 |
|
| Diabetes Mellitus, Experimental | 10.64 |
|
| Prostatic Neoplasms | 10.33 |
|
| Cardiac hypertrophy | 10.2 |
|
| Splenic Diseases | 10.14 |
|
| Hepatomegaly | 10.09 |
|
| Obesity | 10.0 |
|
| Colorectal cancer | 9.51 |
|
| Liver Cirrhosis, Experimental | 9.41 |
|
| Metabolic Syndrome X | 8.62 |
|
| Osteosarcoma | 8.45 |
|
| Splenomegaly | 8.42 |
|
| Chronic obstructive pulmonary disease | 8.21 |
|
| Growth Disorders | 8.01 |
|
| Drug-Related Side Effects and Adverse Reactions | 7.91 |