Definition
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring, thus making the lactone ring 15-membered. Azithromycin is sold under the brand names Zithromax ('Zmax') and Sumamed, and is one of the world's best-selling antibiotics. Azithromycin is used to treat certain bacterial infections, most often bacteria causing middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia and sinusitis. It is also effective against certain sexually transmitted infectious diseases, such as non-gonococcal urethritis and cervicitis. [HMDB]
Top Gene Interactions
Related Pathways
Azithromycin (Zithromax) Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Leishmaniasis, Cutaneous | 15.79 |
|
HIV Wasting Syndrome | 15.19 |
|
Visceral leishmaniasis | 14.76 |
References/Inference Genes
|
Silicosis | 14.66 |
|
Thyroid carcinoma | 14.11 |
|
Glomerulonephritis | 13.36 |
References/Inference Genes
|
Pulmonary Fibrosis | 12.46 | |
Mitochondrial Myopathies | 12.12 |
|
Pleurisy | 11.99 |
|
Burns | 11.75 |
|
Osteoporosis, Postmenopausal | 11.63 |
|
Cachexia | 11.34 |
|
Leishmaniasis | 11.25 |
|
Polymyositis | 11.04 |
|
Reperfusion Injury | 10.87 | |
Heat Stroke | 10.78 |
|
Anthracosis | 10.37 |
|
Hepatolenticular Degeneration | 10.36 |
|
Lichenoid Eruptions | 9.47 |
|
Hemolytic-Uremic Syndrome | 9.23 |
|