Definition
5,7,4'-trihydroxy-flavone, one of the FLAVONES. Flavone found in a wide variety of foodstuffs; buckwheat, cabbage, celeriac, celery, lettuce, oregano, parsley, peppermint, perilla, pummelo juice, thyme, sweet potatoes, green tea and wild carrot [DFC]
Description
Apigenin is a plant-derived flavonoid that has significant promise as a skin cancer chemopreventive agent. Apigenin inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, is increased by differentiating agents via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Apigenin suppresses the 12-O-tetradeconylphorbol-13-acetate-dependent increase in AP1 factor expression and binding to the hINV promoter and the increase in hINV promoter activity. Apigenin also inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. The suppression of PKCdelta activity is associated with reduced phosphorylation of PKCdelta-Y311. Activation of hINV promoter activity by the green tea polyphenol, (-)-epigellocathecin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents can produce opposing actions in keratinocytes. (A7924). Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. This flavonoid provides selective activity to promote caspase-dependent-apoptosis of leukemia cells and uncover an essential role of PKCdelta during the induction of apoptosis by apigenin. (A7925). Apigenin markedly induces the expression of death receptor 5 (DR5) and synergistically acts with exogenous soluble recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in malignant tumor cells. On the other hand, apigenin-mediated induction of DR5 expression is not observed in normal human peripheral blood mononuclear cells. Moreover, apigenin does not sensitize normal human peripheral blood mononuclear cells to TRAIL-induced apoptosis. (A7926).
Apigenin is Found in These Foods
Top Gene Interactions
Related Pathways
Apigenin Health Effects
- 11beta-hydroxysteroid-dehydrogenase inhibitor
- Anti ADD
- Anti aflatoxin
- Anti aging
- Anti allergic
- Anti angiogenic
- Anti arrhythmic
- Anti cancer
- Anti complementary
- Anti dermatitic
- Anti estrogenic
- Anti herpetic
- Anti histaminic
- Anti HIV
- Anti inflammatory
- Anti leukemic
- Anti melanomic
- Anti metastatic
- Anti neoplastic
- Antioxidant
- Anti peristaltic
- Anti proliferant
- Anti spasmodic
- Anti stress
- Anti thyroid
- Antitumor
- Anti viral
- Anxiolytic
- Aromatase inhibitor
- Beta-glucuronidase inhibitor
- Calcium antagonist
- Cancer preventive
- Choleretic
- Central nervous system depressant
- Cyclooxygenase-1 inhibitor
- Cyclooxygenase-2 inhibitor
- Cyclooxygenase inhibitor
- Cytochrome-P450-1A1 inhibitor
- Cytotoxic
- Deiodinase inhibitor
- Differentiator
- Diuretic
- DNA-protective
- HIF-1alpha inhibitor
- Hyaluronidase inhibitor
- Hypotensive
- ICAM-1 inhibitor
- IKK inhibitor
- INOS inhibitor
- Interleukin-6 inhibitor
- Monoamine-oxidase inhibitor
- Mitogen-activated-protein-kinase inhibitor
- Musculotropic
- NADPH-oxidase inhibitor
- NF-kappa-B inhibitor
- Nitric-oxide-synthase inhibitor
- Ornithine-decarboxylase inhibitor
- Cytochrome-P21 inducer
- Pesticide
- Protein kinase C inhibitor
- Polyamine synthesis inhibitor
- Progestational
- Protein-tyrosine-kinase inhibitor
- Quinone-reductase inducer
- Radioprotective
- Sedative
- Sunscreen
- TNF-alpha inhibitor
- Topoisomerase-II inhibitor
- Topoisomerase-I inhibitor
- Utero trophic
- Vasodilator
- VEGF inhibitor
- Anti aggregant
- Anti bacterial
- Xanthine oxidase inhibitor
- Anti mutagenic
- Apoptotic
- Estrogenic
- Inotropic
- Mutagenic
- Myorelaxant
- Nodulation signal
General Information
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Estrogen receptor Estrogen receptor beta Aryl hydrocarbon receptor Progesterone receptor Peroxisome proliferator-activated receptor gamma Cytochrome P450 1A1 Hypoxia-inducible factor 1-alpha Cytochrome P450 1B1 ATPase family AAA domain-containing protein 5 |
16541309 21053930 23611293 11454723 9751507 14579009 |