ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

Definition

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.

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Angiotensin-Converting Enzyme Inhibitors Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Allanson Pantzar McLeod syndrome	24.45	References/Inference Genes References Inference genes 16116425 17036344 ACE AGT AGTR1 REN
RENAL TUBULAR DYSGENESIS	24.45	References/Inference Genes References Inference genes 20454656 ACE AGT AGTR1 REN
Hypertension	23.22	References/Inference Genes References Inference genes 22982863 14751847 19373235 24342267 7721406 12676074 15188945 15243307 23603059 18847324 1149188 18679781 25259750 4040330 10526905 2526952 19109942 24039778 12414515 8021468 10669576 1860718 1432030 21420289 11459117 25139994 6381767 8152482 12149661 7323490 2835134 1394429 15773232 18836702 22214961 20429690 6742791 21393355 20713914 8440307 24965170 1516988 19133994 16868307 17989111 9260993 8188982 12940879 22753205 2831029 1849535 6367368 1663982 17537837 17130675 18420994 15302986 15833808 3346065 19858406 10474778 9194512 45830 62162 15851630 27292124 10400907 21501650 9869009 11501062 12600921 8952600 20837116 12121858 998518 18768397 16618834 24935938 8505092 43064 10694834 21051829 19770776 10075388 21289285 18785976 17272743 20811386 11682445 16788141 25874449 1875449 12084390 8109997 24347665 15314687 26564064 11847185 1071603 19047579 19219041 20237592 22452651 9024144 7721401 12425201 7839143 3158602 6383834 20231528 15699457 15834289 20937366 19018797 ACE AGT AGTR1 AVP BCL2 COL1A1 COL3A1 EDN1 EPO F11 F12 MMP2 MMP9 NPPA NPPB REN TGFB1
Diabetes Mellitus, Experimental	22.83	References/Inference Genes References Inference genes 12967931 16123366 17177138 22191573 21963884 23090186 18829990 12458661 15831366 16959961 ACE AGT BAX BCL2 EDN1 FAS MMP2 MMP9 REN TGFB1
Myocardial infarction	21.25	References/Inference Genes References Inference genes 9527094 20079142 19337937 1328889 16413583 25450231 8131300 16310260 19027736 24358288 1668233 17587755 11743230 ACE AGT BAX BCL2 EPO MMP2 MMP9 MYH7 NPPA NR3C2 REN TGFB1
Left ventricular hypertrophy	19.24	References/Inference Genes References Inference genes 14751847 9455993 8349331 11181017 20837116 15486036 10755198 18679781 24688123 10805403 14644620 10601118 ACE AGT COL1A1 COL3A1 EDN1 NPPA REN
Aortic Valve Insufficiency	18.95	References/Inference Genes References Inference genes 21216836 COL1A1 COL3A1 NPPA NPPB TGFB1
Oral Submucous Fibrosis	16.56	References/Inference Genes References Inference genes 16311067 COL1A1 MMP2 MMP9 TGFB1
Dilated cardiomyopathy	15.83	References/Inference Genes References Inference genes 18628775 21321305 16762803 17943461 11986409 FAS FASLG MYH7 NPPA NPPB NR3C2
Neoplasm Metastasis	15.63	References/Inference Genes References Inference genes 21209944 22321834 23992306 15659795 21942447 18059164 16475674 18930813 17105418 17003774 23146760 16699298 18398872 23707804 18717826 26896736 ABCC4 ACE AGTR1 EPO IL2 MMP2 MMP9 NPPA TGFB1
Alcoholic liver cirrhosis	15.54	References/Inference Genes References Inference genes 23274713 BCL2 COL3A1 MMP2 TGFB1
Calcinosis	14.98	References/Inference Genes References Inference genes 15545515 21335463 24142982 12148126 21193197 COL1A1 EPO MMP2 MMP9 TGFB1
Heart failure	14.48	References/Inference Genes References Inference genes 7034517 20811386 9861300 16333235 1330361 21321305 16101196 8112904 15860969 15732037 18586661 17208988 16762801 16777915 18179782 11707688 16360360 24535859 18214293 11136700 7967349 7969316 11279304 19650993 15722665 12025466 12628948 1647690 ACE AGT AGTR1 AVP EDN1 NPPA NPPB NR3C2 REN
Intracerebral hemorrhage	14.37	References/Inference Genes References Inference genes 16190367 15488484 10698078 19095969 12721362 15529013 14630814 19803787 15277638 ACE BAX BCL2 MMP2 MMP9 NPPB
Liver Cirrhosis	13.47	References/Inference Genes References Inference genes 15787813 15763341 15613622 24321339 2566230 21037076 16679477 1880254 21863215 26396155 24239723 11167689 AGT COL1A1 COL3A1 MMP2 NPPA REN TGFB1
Berylliosis	12.92	References/Inference Genes References Inference genes 15750822 16272364 17927685 17785866 10194187 ACE HLA-DRB1 TGFB1
Hernia, Diaphragmatic	12.14	References/Inference Genes References Inference genes 16292651 9473106 10646786 10693666 11584395 AGT EDN1 NPPA TGFB1
Cardiomyopathies	12.05	References/Inference Genes References Inference genes 16449733 11589785 14745153 17928571 10920071 16127512 16731534 17924179 17943461 16324756 12145768 10716473 AGT AVP EDN1 EPO FAS FASLG NPPB
Pulmonary Emphysema	11.93	References/Inference Genes References Inference genes 25106431 12634787 MMP2 MMP9 TGFB1
Neointima	10.95	References/Inference Genes References Inference genes 17964422 19258495 AGT MMP2 MMP9

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Angiotensin-Converting Enzyme Inhibitors Interacts with Diseases

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Angiotensin-Converting Enzyme Inhibitors

Definition

Top Gene Interactions

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Angiotensin-Converting Enzyme Inhibitors Interacts with Diseases

Angiotensin-Converting Enzyme Inhibitors Interacts with Genes

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