ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

Definition

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.

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Angiotensin-Converting Enzyme Inhibitors Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Allanson Pantzar McLeod syndrome	24.45	References/Inference Genes References Inference genes 16116425 17036344 ACE AGT AGTR1 REN
RENAL TUBULAR DYSGENESIS	24.45	References/Inference Genes References Inference genes 20454656 ACE AGT AGTR1 REN
Hypertension	23.22	References/Inference Genes References Inference genes 21393355 19858406 19018797 9260993 27292124 12940879 1860718 21051829 20937366 19219041 8021468 10526905 12414515 7721401 20429690 18785976 15834289 12425201 6367368 1663982 19047579 22452651 8505092 2835134 25874449 25139994 17989111 8952600 10474778 8152482 8188982 6742791 1849535 45830 19770776 22214961 6383834 18679781 21420289 998518 21501650 17272743 26564064 24342267 15302986 11501062 18768397 1149188 10669576 20837116 23603059 24039778 15851630 4040330 16618834 16788141 11847185 24965170 20231528 16868307 3346065 15314687 10400907 21289285 24935938 19373235 25259750 9024144 11459117 20237592 15773232 12121858 18836702 20713914 62162 1516988 22753205 1394429 17130675 43064 2831029 10694834 15188945 11682445 22982863 3158602 12149661 15699457 12084390 8440307 9194512 15243307 20811386 18420994 7323490 7839143 6381767 19133994 18847324 9869009 8109997 19109942 10075388 1432030 17537837 12676074 14751847 1875449 15833808 7721406 2526952 12600921 1071603 24347665 ACE AGT AGTR1 AVP BCL2 COL1A1 COL3A1 EDN1 EPO F11 F12 MMP2 MMP9 NPPA NPPB REN TGFB1
Diabetes Mellitus, Experimental	22.83	References/Inference Genes References Inference genes 17177138 21963884 18829990 15831366 22191573 12967931 16123366 12458661 16959961 23090186 ACE AGT BAX BCL2 EDN1 FAS MMP2 MMP9 REN TGFB1
Myocardial infarction	21.25	References/Inference Genes References Inference genes 24358288 20079142 1668233 17587755 9527094 19337937 16310260 19027736 11743230 8131300 1328889 16413583 25450231 ACE AGT BAX BCL2 EPO MMP2 MMP9 MYH7 NPPA NR3C2 REN TGFB1
Left ventricular hypertrophy	19.24	References/Inference Genes References Inference genes 10805403 18679781 11181017 8349331 15486036 20837116 10601118 9455993 24688123 14644620 10755198 14751847 ACE AGT COL1A1 COL3A1 EDN1 NPPA REN
Aortic Valve Insufficiency	18.95	References/Inference Genes References Inference genes 21216836 COL1A1 COL3A1 NPPA NPPB TGFB1
Oral Submucous Fibrosis	16.56	References/Inference Genes References Inference genes 16311067 COL1A1 MMP2 MMP9 TGFB1
Dilated cardiomyopathy	15.83	References/Inference Genes References Inference genes 16762803 17943461 21321305 18628775 11986409 FAS FASLG MYH7 NPPA NPPB NR3C2
Neoplasm Metastasis	15.63	References/Inference Genes References Inference genes 21942447 21209944 22321834 17105418 23992306 18930813 16475674 17003774 23707804 18717826 23146760 26896736 16699298 18398872 15659795 18059164 ABCC4 ACE AGTR1 EPO IL2 MMP2 MMP9 NPPA TGFB1
Alcoholic liver cirrhosis	15.54	References/Inference Genes References Inference genes 23274713 BCL2 COL3A1 MMP2 TGFB1
Calcinosis	14.98	References/Inference Genes References Inference genes 21335463 24142982 12148126 15545515 21193197 COL1A1 EPO MMP2 MMP9 TGFB1
Heart failure	14.48	References/Inference Genes References Inference genes 11279304 16333235 12025466 19650993 15722665 1647690 20811386 18179782 21321305 16777915 16762801 15860969 7034517 16360360 7969316 15732037 12628948 18214293 11707688 18586661 9861300 1330361 17208988 7967349 16101196 24535859 8112904 11136700 ACE AGT AGTR1 AVP EDN1 NPPA NPPB NR3C2 REN
Intracerebral hemorrhage	14.37	References/Inference Genes References Inference genes 19095969 15277638 16190367 14630814 10698078 15529013 19803787 15488484 12721362 ACE BAX BCL2 MMP2 MMP9 NPPB
Liver Cirrhosis	13.47	References/Inference Genes References Inference genes 15763341 15787813 11167689 24239723 21037076 2566230 15613622 16679477 26396155 1880254 24321339 21863215 AGT COL1A1 COL3A1 MMP2 NPPA REN TGFB1
Berylliosis	12.92	References/Inference Genes References Inference genes 16272364 17785866 10194187 15750822 17927685 ACE HLA-DRB1 TGFB1
Hernia, Diaphragmatic	12.14	References/Inference Genes References Inference genes 9473106 10693666 16292651 11584395 10646786 AGT EDN1 NPPA TGFB1
Cardiomyopathies	12.05	References/Inference Genes References Inference genes 16324756 10716473 11589785 17943461 14745153 16449733 17924179 17928571 10920071 16127512 12145768 16731534 AGT AVP EDN1 EPO FAS FASLG NPPB
Pulmonary Emphysema	11.93	References/Inference Genes References Inference genes 12634787 25106431 MMP2 MMP9 TGFB1
Neointima	10.95	References/Inference Genes References Inference genes 19258495 17964422 AGT MMP2 MMP9

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Angiotensin-Converting Enzyme Inhibitors Interacts with Diseases

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Angiotensin-Converting Enzyme Inhibitors

Definition

Top Gene Interactions

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Angiotensin-Converting Enzyme Inhibitors Interacts with Diseases

Angiotensin-Converting Enzyme Inhibitors Interacts with Genes

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