Definition
Constit. of roots and leaves of angelica (Angelica archangelica). Found in roots and on surface of parsnips and diseased celery Angelicin is a furanocoumarin. It can be found in Bituminaria bituminosa. It is present in the list of IARC Group 3 carcinogens (Angelicin plus ultraviolet A radiation). (Wikipedia)
Description
Angelicin is found in coriander. Angelicin is a constituent of roots and leaves of angelica (Angelica archangelica). Angelicin is found in roots and on surface of parsnips and diseased celery.Angelicin is a furanocoumarin. It can be found in Bituminaria bituminosa. It is present in the list of IARC Group 3 carcinogens (Angelicin plus ultraviolet A radiation). (Wikipedia).
Top Gene Interactions
Related Pathways
Angelicin Health Effects
General Information
- Uses/Sources: Angelicin is used as tranquilliser, sedative, or anticonvulsant. (L579)
- Health Effects: Furocoumarins can cause photosensitization dermatitis especially if these compounds come into contact with the skin. Some furocoumarins, especially bifunctional furocoumarins, are known to be carcinogenic (A15105). Furocoumarin photochemotherapy is known to induce a number of side-effects including erythema, edema, hyperpigmentation, and premature aging of skin. All photobiological effects of furocoumarins result from their photochemical reactions. Because many dietary or water soluble furocoumarins are strong inhibitors of cytochrome P450s, they will also cause adverse drug reactions when taken with other drugs. Limited evidence of carcinogenic effect. (L579)
- Symptoms: Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. (L579)
- Treatment: If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. If swallowed, wash out mouth with water provided person is conscious. Call physician. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. (L579)
Mechanism of Action
| Target Name | Mechanism of Action | References |
|---|---|---|
|
Cytochrome P450 3A4 Nuclear factor NF-kappa-B p105 subunit Cytochrome P450 2C9 |
17995595 20980154 |
|
| DNA | Upon long wavelength UV irradiation, forms monoadduct with double-stranded DNA and react with unsaturated fatty acids. Inhibits DNA and RNA synthesis and cell replication in Ehrlich ascites tumor cells. (L579) |
6504703 6746605 2009 |
Angelicin Interacts with Diseases
| Disease | Inference Score | References/Inference Genes |
| Prostatic Neoplasms | 13.77 |
|
| Hyperoxia | 12.99 |
|
| Growth Disorders | 12.91 |
|
| Coxsackievirus Infections | 12.28 |
|
| Lung Injury | 11.89 |
|
| Drug-Related Side Effects and Adverse Reactions | 11.14 | |
| Rheumatoid arthritis | 10.28 |
|
| Cardiac hypertrophy | 10.19 |
|
| Splenic Diseases | 10.14 |
|
| Obesity | 10.05 |
|
| Liver Cirrhosis, Experimental | 9.41 |
|
| Myocarditis | 8.71 |
|
| Splenomegaly | 8.42 |
|
| Chronic obstructive pulmonary disease | 8.21 |
|
| Atrophy | 7.66 |
|
| Male infertility | 7.39 |
|
| Hypouricemia, Renal, 2 | 7.22 |
|
| Abortion, Spontaneous | 7.16 |
|
| Dermatitis, Contact | 7.08 |
|
| Micronuclei, Chromosome-Defective | 7.08 |
|