Definition
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Description
Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Extensive, primarily hepatic, converted to glutathione conjugate. Half Life: 8-9 hours
- Uses/Sources: For treatment of acute myeloid leukaemia.
- Symptoms: Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).
- Route of Exposure: Poorly absorbed.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
DNA topoisomerase 2-alpha Potassium voltage-gated channel subfamily H member 2 DNA |
9582297 15148258 17900923 11752352 17139284 1322791 17016423 11716434 11006484 10691026 11473732 1311390 |
Amsacrine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Breast carcinoma | 33.67 |
References/Inference Genes
|
Male infertility | 20.66 | |
Cell Transformation, Neoplastic | 20.16 | |
Disease Progression | 19.73 | |
Adenocarcinoma | 19.71 | |
Prostatic Neoplasms | 19.37 |
References/Inference Genes
|
Carcinoma | 16.22 | |
Prostatic Intraepithelial Neoplasia | 14.18 |
|
Hepatocellular carcinoma | 13.44 | |
Colonic neoplasm | 12.42 | |
Polycystic ovary syndrome | 11.81 |
|
Adenocarcinoma, Clear Cell | 11.61 |
|
Recurrence | 11.28 |
References/Inference Genes
|
Head and Neck Neoplasms | 11.19 |
|
Infertility, Female | 10.59 |
|
Chronic lymphocytic leukemia | 10.58 |
References/Inference Genes
|
Azoospermia | 9.73 |
|
Urinary Bladder Neoplasms | 9.71 | |
Endometrial neoplasm | 9.62 |
|
Osteolysis | 9.58 |
|