Definition
Isol. from garlic (Allium sativum) extracts. Nutriceutical with anti-cancer props. Ajoene (pronounced /???ho?i?n/) is a chemical compound available from garlic (Allium sativum). The name (and pronunciation) is derived from 'ajo', the Spanish word for garlic. It is found as a mixture of two isomers, E-, and Z- 4,5,9-trithiadodeca-1,6,11-triene 9-oxide.; Ajoene, an unsaturated disulfide, is formed from the bonding of three allicin molecules. Allicin is a sulfinyl compound that gives garlic its strong odor and flavor. The release of allicin occurs after a garlic clove is crushed or finely chopped. Subsequent formation of ajoene occurs when allicin is dissolved in various solvents including edible oils. Ajoene is also found in garlic extract. Ajoene is most stable and most abundant in macerate of garlic (chopped garlic in edible oil).
Top Gene Interactions
Ajoene Health Effects
- Anti allergic
- Anti herpetic
- Anti HIV
- Anti inflammatory
- Anti leukemic
- Anti leukotriene
- Anti lymphomic
- Anti malarial
- Anti metastatic
- Anti mycotic
- Anti proliferant
- Anti prostaglandin
- Anti septic
- Anti staphylococcic
- Anti stomatitic
- Anti thrombotic
- Antitumor
- Anti viral
- Calcium antagonist
- Candidicide
- Candidistat
- Cyclooxygenase-2 inhibitor
- Cyclooxygenase inhibitor
- Cytostatic
- Cytotoxic
- Fungicide
- Fungistat
- Gram(+)icide
- Gram(-)icide
- Hypocholesterolemic
- Lipolytic
- Lipoxygenase inhibitor
- Nitric-oxide inhibitor
- Pesticide
- Prostaglandin inhibitor
- Protisticide
- Tineacide
- Trypanocide
- Anti aggregant
- Anti bacterial
- Anti mutagenic
- Anti platelet
- Anti trypanosomic
- Apoptotic
- NF-kappa-B inducer
Ajoene Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Muscular Dystrophies | 5.86 |
|
Amyloidosis | 5.6 |
|
Organophosphate Poisoning | 5.03 |
|
Growth Disorders | 4.8 |
|
Amphetamine-Related Disorders | 4.62 | |
Prenatal Injuries | 4.59 |
|
Renal cell carcinoma | 4.49 |
|
Alzheimer's Disease | 4.46 |
|
Learning Disorders | 4.29 |
|
Movement disorder | 4.29 |
|
Nervous System Diseases | 4.16 |
|
Tremor | 4.15 |
|
Poisoning | 4.14 |
|
Memory Disorders | 4.13 |
|
Drug-Related Side Effects and Adverse Reactions | 3.9 | |
Prostatic Neoplasms | 3.8 |
|
Breast carcinoma | 3.72 |
|
Liver Cirrhosis, Experimental | 3.67 |
|
Seizures | 3.58 |
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