Definition
Description
Adenosine is Found in These Foods
Top Gene Interactions
Related Pathways
Adenosine Health Effects
- Analgesic
- Anti arrhythmic
- Anti diuretic
- Anti endotoxic
- Anti hypertensive
- Anti insomniac
- Anti lipolytic
- Anti spasmodic
- Anti tachycardic
- Anxiolytic
- Arteriodilator
- Glucogonogenic
- Hypocholesterolemic
- Hypoglycemic
- Hypotensive
- Immunomodulator
- Insulinic
- Laxative
- Lipolytic
- Platelet aggregation factor inhibitor
- Pyrogenic
- Respirastimulant
- Secretomotor
- Sedative
- Vasodilator
- Anti aggregant
- Myorelaxant
General Information
- Metabolism: Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol. Half Life: Less than 10 secs
- Uses/Sources: Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.
- Health Effects: Chronically high levels of adeonsine are associated with Adenosine Deaminase Deficiency.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Protein kinase C beta type Glyceraldehyde-3-phosphate dehydrogenase Adenosine receptor A1 Adenosine receptor A2a Epidermal growth factor receptor Adenosine deaminase Inosine-5'-monophosphate dehydrogenase 2 Inosine-5'-monophosphate dehydrogenase 1 Adenosine receptor A3 Adenosine receptor A2b Heat shock 70 kDa protein 1A/1B |
9934461 17321471 19749080 20370661 9089334 7562915 17442976 7932587 16339914 18583139 18404447 11752352 8258836 22104008 19256508 17438146 20370662 20136829 10360754 |
Adenosine Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Brain Ischemia | 32.57 |
|
Diabetes Mellitus, Experimental | 30.16 |
|
Liver Cirrhosis, Experimental | 29.76 |
|
Radiation Injuries, Experimental | 29.34 |
|
Prostatic Neoplasms | 28.34 |
|
Lung Neoplasms | 27.65 |
|
Breast carcinoma | 25.95 |
|
Rheumatoid arthritis | 25.12 |
|
Neoplasm Metastasis | 24.93 |
|
Sepsis | 24.51 |
|
Pancreatic carcinoma | 24.0 |
|
Psoriasis | 23.96 |
|
Brain Injuries | 23.88 |
|
Reperfusion Injury | 23.47 |
|
Myocardial infarction | 22.69 |
|
Myocardial Reperfusion Injury | 22.06 |
|
Ulcerative colitis | 21.91 |
|
Entamoebiasis | 21.11 |
|
Leishmaniasis, Cutaneous | 20.59 |
|
Stomach Neoplasms | 20.38 |
|