Definition
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP can be produced during ATP synthesis by the enzyme adenylate kinase. AMP has recently been approved as a 'Bitter Blocker' additive to foodstuffs. When AMP is added to bitter foods or foods with a bitter aftertaste it makes them seem 'sweeter'. This potentially makes lower calorie food products more palatable [HMDB]
Description
Amprenavir is only found in individuals that have used or taken this drug. It is a protease inhibitor used to treat HIV infection.Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic. Amprenavir is metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system. The 2 major metabolites result from oxidation of the tetrahydrofuran and aniline moieties. Glucuronide conjugates of oxidized metabolites have been identified as minor metabolites in urine and feces. Half Life: 7.1-10.6 hours
- Uses/Sources: For the treatment of HIV-1 infection in combination with other antiretroviral agents.
- Treatment: If overdosage occurs, the patient should be monitored for evidence of toxicity and standard supportive treatment applied as necessary. (L1712)
- Route of Exposure: Rapidly absorbed after oral administration in HIV-1-infected patients with a time to peak concentration (Tmax) typically between 1 and 2 hours after a single oral dose. The absolute oral bioavailability of amprenavir in humans has not been established.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
Cytochrome P450 3A4 Cytochrome P450 3A5 Cytosolic 10-formyltetrahydrofolate dehydrogenase Multidrug resistance protein 1 Cathepsin D |
17638694 16248836 22409598 17664327 |
Adenosine Monophosphate Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
De Sanctis-Cacchione syndrome | 7.41 |
|
Cerebrooculofacioskeletal Syndrome 1 | 7.06 |
|
UV-SENSITIVE SYNDROME 1 | 7.06 |
|
Glycogen Storage Disease Type V | 6.88 |
|
Arthrogryposis | 6.71 |
|
Rhabdomyosarcoma, Alveolar | 6.65 |
|
Cockayne Syndrome | 6.6 |
|
Aging, Premature | 6.16 |
|
Muscular Dystrophy, Animal | 6.13 |
|
Microphthalmos | 6.12 |
|
Bowen's Disease | 5.79 |
|
Age-related macular degeneration | 5.71 | |
Leukemia-Lymphoma, Adult T-Cell | 5.6 |
|
Ceroid lipofuscinosis, neuronal 1, infantile | 5.58 |
|
Creutzfeldt jacob disease | 5.55 |
|
Microcephaly | 5.45 |
|
Psychomotor Disorders | 5.33 |
|
Cataract | 5.22 |
|
Growth Disorders | 5.11 |
|
Hearing loss | 5.02 |
|