Azelaic Acid Health Effects
- Metabolism: Mainly excreted unchanged in the urine but undergoes some b-oxidation to shorter chain dicarboxylic acids. Route of Elimination: Azelaic acid is mainly excreted unchanged in the urine, but undergoes some нф-oxidation to shorter chain dicarboxylic acids. Half Life: The observed half-lives in healthy subjects are approximately 45 minutes after oral dosing and 12 hours after topical dosing, indicating percutaneous absorption rate-limited kinetics.
- Uses/Sources: For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
- Route of Exposure: Approximately 4% of the topically applied azelaic acid is systemically absorbed.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral LD50 in rat: >5 g/kg
Mechanism of Action
|Target Name||Mechanism of Action||References|
3-oxo-5-alpha-steroid 4-dehydrogenase 2