Description
1,4-Naphthoquinone or para-naphthoquinone is an organic compound derived from naphthalene. Several isomeric naphthoquinones are known, notably 1,2-naphthoquinone. 1,4-Naphthoquinone forms volatile yellow triclinic crystals and has a sharp odor similar to benzoquinone. It is almost insoluble in cold water, slightly soluble in petroleum ether, and more soluble in polar organic solvents. In alkaline solutions it produces a reddish-brown color. Vitamin K is a derivative of 1,4-naphthoquinone. It is a planar molecule with one aromatic ring fused to a quinone subunit. Naphthalene is a constituent of jet fuel, diesel fuel and cigarette smoke. It is also a byproduct of incomplete combustion and hence is an ubiquitous environmental pollutant. The typical air concentration of naphthalene in cities is about 0.18 ppb.
Top Gene Interactions
Related Pathways
1,4-Naphthoquinone Health Effects
General Information
- Uses/Sources: This is a toxic chemical found in cigarettes or generated by tobacco combustion.
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
DNA topoisomerase 2-alpha Amine oxidase [flavin-containing] A Amine oxidase [flavin-containing] B Dual specificity mitogen-activated protein kinase kinase 1 M-phase inducer phosphatase 2 |
22071524 22218491 19028102 18077363 |
1,4-Naphthoquinone Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Prostatic Neoplasms | 35.99 | |
Breast carcinoma | 22.78 | |
Reperfusion Injury | 21.08 | |
Lung Injury | 19.11 | |
Kidney Failure, Chronic | 18.99 | |
Chronic obstructive pulmonary disease | 16.55 |
References/Inference Genes
|
Hepatocellular carcinoma | 16.53 | |
Cardiac hypertrophy | 16.06 | |
Colorectal cancer | 14.8 | |
Acute lymphoblastic leukemia | 14.77 |
|
Glomerulonephritis | 14.76 | |
Leishmaniasis, Cutaneous | 14.54 |
|
Dermatitis, Contact | 13.81 |
|
Myocardial Reperfusion Injury | 13.73 |
References/Inference Genes
|
Stomach Neoplasms | 13.47 | |
Allergy | 13.46 | |
Drug-induced liver injury | 13.43 | |
Brain Ischemia | 13.41 | |
Nephritis, Interstitial | 13.19 | |
Squamous cell carcinoma | 12.88 |
References/Inference Genes
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