1,4-Naphthoquinone or para-naphthoquinone is an organic compound derived from naphthalene. Several isomeric naphthoquinones are known, notably 1,2-naphthoquinone. 1,4-Naphthoquinone forms volatile yellow triclinic crystals and has a sharp odor similar to benzoquinone. It is almost insoluble in cold water, slightly soluble in petroleum ether, and more soluble in polar organic solvents. In alkaline solutions it produces a reddish-brown color. Vitamin K is a derivative of 1,4-naphthoquinone. It is a planar molecule with one aromatic ring fused to a quinone subunit. Naphthalene is a constituent of jet fuel, diesel fuel and cigarette smoke. It is also a byproduct of incomplete combustion and hence is an ubiquitous environmental pollutant. The typical air concentration of naphthalene in cities is about 0.18 ppb.
Top Gene Interactions
- Uses/Sources: This is a toxic chemical found in cigarettes or generated by tobacco combustion.
Mechanism of Action
1,4-Naphthoquinone Interacts with Diseases
|Disease||Inference Score||References/Inference Genes|
|Kidney Failure, Chronic||18.99|
|Chronic obstructive pulmonary disease||16.55|
|Acute lymphoblastic leukemia||14.77|
|Myocardial Reperfusion Injury||13.73|
|Drug-induced liver injury||13.43|
|Squamous cell carcinoma||12.88|